Cigarette smoking, cytochrome P450 1A1 polymorphisms, and breast cancer risk in the Nurses' Health Study.
Ishibe N, Hankinson SE, Colditz GA, Spiegelman D, Willett WC, Speizer FE, Kelsey KT, Hunter DJ. Cigarette smoking, cytochrome P450 1A1 polymorphisms, and breast cancer risk in the Nurses' Health Study. Cancer Research 1998, 58: 667-71. PMID: 9485019.Peer-Reviewed Original ResearchConceptsBreast cancer riskNurses' Health StudyCigarette smokingBreast cancerCancer riskHealth StudyAryl hydrocarbon hydroxylase activityRelative riskCYP1A1 polymorphismsIncident breast cancer casesHydroxylase activityVariant CYP1A1 genotypesBreast cancer ratesBreast cancer incidenceConfidence intervalsCytochrome P450 1A1 (CYP1A1) polymorphismsCase-control studyConditional logistic regressionBreast cancer casesExon 7 polymorphismHomozygous wild typeSusceptible womenModifiable causesCancer incidenceCaucasian women