1999
N‐acetyl transferase 2 genotypes, meat intake and breast cancer risk
Gertig D, Hankinson S, Hough H, Spiegelman D, Colditz G, Willett W, Kelsey K, Hunter D. N‐acetyl transferase 2 genotypes, meat intake and breast cancer risk. International Journal Of Cancer 1999, 80: 13-17. PMID: 9935222, DOI: 10.1002/(sici)1097-0215(19990105)80:1<13::aid-ijc3>3.0.co;2-w.Peer-Reviewed Original ResearchConceptsBreast cancer riskRed meat intakeMeat intakeRapid acetylatorsBreast cancerSlow acetylatorsCancer riskHealth StudyLow red meat intakeHigh red meat intakeNurses' Health StudyHeterocyclic aminesLack of associationHigh-temperature cooking methodsFrequent intakeNAT2 genotypeBlood drawAcetylator genotypeBlood samplesAcetylatorsSignificant associationCancerIntakeMajor causeHuman carcinogenesis
1997
A prospective study of NAT2 acetylation genotype, cigarette smoking, and risk of breast cancer.
Hunter DJ, Hankinson SE, Hough H, Gertig DM, Garcia-Closas M, Spiegelman D, Manson JE, Colditz GA, Willett WC, Speizer FE, Kelsey K. A prospective study of NAT2 acetylation genotype, cigarette smoking, and risk of breast cancer. Carcinogenesis 1997, 18: 2127-2132. PMID: 9395212, DOI: 10.1093/carcin/18.11.2127.Peer-Reviewed Original ResearchConceptsRapid acetylatorsBreast cancerSlow acetylatorsCigarette smokingProspective studyFast acetylatorsNAT2 genotypeRelative riskFast NAT2 acetylatorsNAT2 acetylation genotypeMultivariate relative riskPost-menopausal womenBreast cancer riskNAT2 acetylation statusCase-control studyNon-significant elevationN-acetyltransferase 2 geneAcetylation genotypeNever smokersCurrent smokersCurrent smokingNAT2 acetylatorsFirst pregnancyIncident casesSignificant elevation