2021
Estimating the natural indirect effect and the mediation proportion via the product method
Cheng C, Spiegelman D, Li F. Estimating the natural indirect effect and the mediation proportion via the product method. BMC Medical Research Methodology 2021, 21: 253. PMID: 34800985, PMCID: PMC8606099, DOI: 10.1186/s12874-021-01425-4.Peer-Reviewed Original ResearchConceptsInterval estimatorsApproximate estimatorExact estimatorMultivariate delta methodFinite sample performanceProduct methodNon-negligible biasBinary outcomesRare outcome assumptionExact expressionDelta methodVariance estimationEmpirical performanceEstimatorCommon data typesBootstrap approachBinary mediatorNatural indirect effectSample size
1991
Cost-efficient study designs for binary response data with Gaussian covariate measurement error.
Spiegelman D, Gray R. Cost-efficient study designs for binary response data with Gaussian covariate measurement error. Biometrics 1991, 47: 851-69. PMID: 1789885, DOI: 10.2307/2532644.Peer-Reviewed Original ResearchConceptsStudy designValidation studyEpidemiologic cohort studiesOverall sample sizeExposure measurementsCohort studyOutcome ascertainmentRelative riskExposure measurement methodsSample of subjectsExposure variablesOptimal study designDisease frequencySample sizeInternal validation studyExposure assessmentValidation substudySubjectsPrimary investigationBest methodProportionSubstudyStudy