2021
Depression, Religiosity, and Telomere Length in the Study on Stress, Spirituality, and Health (SSSH)
Isehunwa OO, Warner ET, Spiegelman D, Zhang Y, Palmer JR, Kanaya AM, Cole SA, Tworoger SS, Shields LO, Gu Y, Kent BV, De Vivo I, Shields AE. Depression, Religiosity, and Telomere Length in the Study on Stress, Spirituality, and Health (SSSH). International Journal Of Mental Health And Addiction 2021, 20: 1465-1484. PMID: 35747346, PMCID: PMC9211376, DOI: 10.1007/s11469-020-00455-1.Peer-Reviewed Original ResearchRelative leukocyte telomere lengthCohort-specific analysesTelomere lengthLeukocyte telomere lengthEthnic populationsQuantitative polymerase chain reactionProspective studyPolymerase chain reactionEffect modificationRace/ethnic populationsProspective associationsDepressionChain reactionAssociationEuropean ancestry populationsAncestry populationsHealthModifying influenceFurther researchPopulationResources of resilienceMixed resultsCohort
2011
Fatty acids in the de novo lipogenesis pathway and risk of coronary heart disease: the Cardiovascular Health Study
Wu J, Lemaitre RN, Imamura F, King IB, Song X, Spiegelman D, Siscovick DS, Mozaffarian D. Fatty acids in the de novo lipogenesis pathway and risk of coronary heart disease: the Cardiovascular Health Study. American Journal Of Clinical Nutrition 2011, 94: 431-438. PMID: 21697077, PMCID: PMC3142722, DOI: 10.3945/ajcn.111.012054.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseNonfatal myocardial infarctionSudden cardiac arrestFatal coronary heart diseaseTotal coronary heart diseaseIncident coronary heart diseaseDe novo lipogenesisHigh riskCHD eventsHeart diseaseMultivariable-adjusted Cox proportional hazardsCommunity-based prospective studySecondary analysisCardiovascular disease risk factorsCardiovascular Health StudyDisease risk factorsFatty acidsCox proportional hazardsDe novo lipogenesis pathwayCHD deathCHD outcomesProspective studyCardiac arrestMyocardial infarctionMedical records
2009
Intakes of Fruit, Vegetables, and Carotenoids and Renal Cell Cancer Risk: A Pooled Analysis of 13 Prospective Studies
Lee JE, Männistö S, Spiegelman D, Hunter DJ, Bernstein L, van den Brandt PA, Buring JE, Cho E, English DR, Flood A, Freudenheim JL, Giles GG, Giovannucci E, Håkansson N, Horn-Ross PL, Jacobs EJ, Leitzmann MF, Marshall JR, McCullough ML, Miller AB, Rohan TE, Ross JA, Schatzkin A, Schouten LJ, Virtamo J, Wolk A, Zhang SM, Smith-Warner SA. Intakes of Fruit, Vegetables, and Carotenoids and Renal Cell Cancer Risk: A Pooled Analysis of 13 Prospective Studies. Cancer Epidemiology Biomarkers & Prevention 2009, 18: 1730-1739. PMID: 19505906, PMCID: PMC2883186, DOI: 10.1158/1055-9965.epi-09-0045.Peer-Reviewed Original ResearchConceptsPooled multivariate relative risksRenal cell cancerMultivariate relative riskCell cancerRelative riskVegetable consumptionProspective studyPooled analysisStudy-specific relative risksRenal cell cancer riskCox proportional hazards modelFood frequency questionnaireIntake of fruitsLutein/zeaxanthinProportional hazards modelRandom-effects modelTotal vegetablesIncident casesLowest quintileVegetable intakeCancer riskHazards modelCancerTotal fruitRisk
2005
Fruits and Vegetables and Ovarian Cancer Risk in a Pooled Analysis of 12 Cohort Studies
Koushik A, Hunter DJ, Spiegelman D, Anderson KE, Arslan AA, Beeson WL, van den Brandt PA, Buring JE, Cerhan JR, Colditz GA, Fraser GE, Freudenheim JL, Genkinger JM, Goldbohm RA, Hankinson SE, Koenig KL, Larsson SC, Leitzmann M, McCullough ML, Miller AB, Patel A, Rohan TE, Schatzkin A, Smit E, Willett WC, Wolk A, Zhang SM, Smith-Warner SA. Fruits and Vegetables and Ovarian Cancer Risk in a Pooled Analysis of 12 Cohort Studies. Cancer Epidemiology Biomarkers & Prevention 2005, 14: 2160-2167. PMID: 16172226, DOI: 10.1158/1055-9965.epi-05-0218.Peer-Reviewed Original ResearchConceptsOvarian cancer riskVegetable intakeOvarian cancerCancer riskRelative riskPooled multivariate relative risksStudy-specific relative risksInvasive epithelial ovarian cancerCox proportional hazards modelTotal fruit intakeMultivariate relative riskFood frequency questionnaireTotal vegetable intakeEpithelial ovarian cancerProportional hazards modelDifferent histologic typesRandom-effects modelCancer-preventive actionsCohort studyHistologic typeProspective studyPooled analysisFruit intakeLowest quartileHazards model
2004
Reproductive Factors, Hormonal Contraception, and Risk of Uterine Leiomyomata in African-American Women: A Prospective Study
Wise LA, Palmer JR, Harlow BL, Spiegelman D, Stewart EA, Adams-Campbell LL, Rosenberg L. Reproductive Factors, Hormonal Contraception, and Risk of Uterine Leiomyomata in African-American Women: A Prospective Study. American Journal Of Epidemiology 2004, 159: 113-123. PMID: 14718211, PMCID: PMC1847588, DOI: 10.1093/aje/kwh016.Peer-Reviewed Original ResearchConceptsUS black womenUterine leiomyomataHormonal contraceptionReproductive factorsSelf-reported uterine leiomyomataProspective cohort studyBody mass indexIncidence rate ratiosCox regression modelSelf-reported diagnosisBlack womenAfrican American womenReproductive covariatesCohort studyPremenopausal womenAlcohol intakeMass indexProspective studyInverse associationHormonal factorsLast birthLeiomyomataReproductive historyNew casesFirst birth
2003
A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk.
Han J, Hankinson SE, De Vivo I, Spiegelman D, Tamimi RM, Mohrenweiser HW, Colditz GA, Hunter DJ. A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk. Cancer Research 2003, 63: 8536-41. PMID: 14679022.Peer-Reviewed Original ResearchConceptsBreast cancer riskBeta-carotene levelsCancer riskInverse associationHealth StudyXRCC1 geneNurses' Health StudyMultivariate odds ratiosCase-control studyPotential protective effectPresent study populationHaplotype-tagging single nucleotide polymorphismsXRCC1 haplotypesCigarette smokingProspective studyCaucasian womenEffect modificationOdds ratioBreast cancerProtective effectStudy populationOxidative DNA damageBreast carcinogenesisGene-environment interactionsPlasma carotenoidsProspective study of the association of changes in dietary intake, physical activity, alcohol consumption, and smoking with 9-y gain in waist circumference among 16 587 US men
Koh-Banerjee P, Chu NF, Spiegelman D, Rosner B, Colditz G, Willett W, Rimm E. Prospective study of the association of changes in dietary intake, physical activity, alcohol consumption, and smoking with 9-y gain in waist circumference among 16 587 US men. American Journal Of Clinical Nutrition 2003, 78: 719-727. PMID: 14522729, DOI: 10.1093/ajcn/78.4.719.Peer-Reviewed Original ResearchConceptsWaist gainMetabolic equivalent taskWaist circumferenceAssociation of changesPhysical activityUS menAlcohol consumptionLifestyle factorsTrans fatsBody mass indexFiber/dVigorous physical activityAbdominal adipose tissueAbdominal obesityProspective cohortMass indexProspective studySmoking cessationProspective dataChronic diseasesDietary intakeSelf-report questionnairesAdipose tissueFiber consumptionEnergy intakeFruits, vegetables and lung cancer: A pooled analysis of cohort studies
Smith‐Warner S, Spiegelman D, Yaun S, Albanes D, Beeson WL, van den Brandt PA, Feskanich D, Folsom AR, Fraser GE, Freudenheim JL, Giovannucci E, Goldbohm RA, Graham S, Kushi LH, Miller AB, Pietinen P, Rohan TE, Speizer FE, Willett WC, Hunter DJ. Fruits, vegetables and lung cancer: A pooled analysis of cohort studies. International Journal Of Cancer 2003, 107: 1001-1011. PMID: 14601062, DOI: 10.1002/ijc.11490.Peer-Reviewed Original ResearchConceptsLung cancer riskCancer riskVegetable consumptionLung cancerRelative riskLung cancer risk factorsStudy-specific relative risksIncident lung cancer casesTotal fruitCancer risk factorsLung cancer incidenceLung cancer casesTotal vegetable consumptionRandom-effects modelCohort studyCurrent smokersSmoking habitsProspective studyQuintiles 2Pooled analysisLowest quintileResidual confoundingInverse associationRisk factorsCancer incidencePremenopausal Fat Intake and Risk of Breast Cancer
Cho E, Spiegelman D, Hunter DJ, Chen WY, Stampfer MJ, Colditz GA, Willett WC. Premenopausal Fat Intake and Risk of Breast Cancer. Journal Of The National Cancer Institute 2003, 95: 1079-1085. PMID: 12865454, DOI: 10.1093/jnci/95.14.1079.Peer-Reviewed Original ResearchConceptsBreast cancer riskDietary fat intakeHigh-fat dairy foodsHealth Study IIFat intakeBreast cancerCancer riskRelative riskPremenopausal womenIncident invasive breast cancerNurses' Health Study IIElevated breast cancer riskRed meatMultivariable relative risksAnimal fat intakeFood frequency questionnaireInvasive breast cancerConfidence intervalsCase-control studyDairy foodsPremenopausal yearsPostmenopausal womenProspective studyHighest quintileLowest quintile
2002
Nutrient intake and body weight in a large HIV cohort that includes women and minorities
WOODS MN, SPIEGELMAN D, Knox TA, FORRESTER JE, CONNORS JL, SKINNER SC, Silva M, KIM JH, GORBACH SL. Nutrient intake and body weight in a large HIV cohort that includes women and minorities. Journal Of The Academy Of Nutrition And Dietetics 2002, 102: 203-211. PMID: 11846114, DOI: 10.1016/s0002-8223(02)90049-0.Peer-Reviewed Original ResearchConceptsVitamin/mineral supplementsNutrient intakeMicronutrient intakeBaseline nutrient intakeLarge HIV cohortCD4 cell countCD4 lymphocyte countHIV-positive populationBody mass indexInadequate nutrient intakeStudy sampleNHANES III dataWilcoxon rank sum testCubic spline modelsMineral supplementsRank sum testHIV cohortLymphocyte countSpearman correlation coefficientMass indexProspective studyFood recordsMedian intakeDietary intakeNutritional intake
2001
Prospective Study of Zinc Intake and the Risk of Age-Related Macular Degeneration
Cho E, Stampfer M, Seddon J, Hung S, Spiegelman D, Rimm E, Willett W, Hankinson S. Prospective Study of Zinc Intake and the Risk of Age-Related Macular Degeneration. Annals Of Epidemiology 2001, 11: 328-336. PMID: 11399447, DOI: 10.1016/s1047-2797(01)00217-4.Peer-Reviewed Original ResearchConceptsAge-related macular degenerationZinc intakeRelative riskProspective studyLowest quintileMacular degenerationRisk of AMDDiagnosis of AMDSemiquantitative food frequency questionnaireMultivariate relative riskPooled relative riskFood frequency questionnaireLarge prospective studiesDietary zinc intakeVisual acuity lossTotal zinc intakePotential risk factorsRisk of AgeMultivariate adjustmentIncident casesAcuity lossHighest quintileLong-term benefitsRisk factorsZinc supplementsTypes of dietary fat and breast cancer: A pooled analysis of cohort studies
Smith‐Warner S, Spiegelman D, Adami H, Beeson W, van den Brandt P, Folsom A, Fraser G, Freudenheim J, Goldbohm R, Graham S, Kushi L, Miller A, Rohan T, Speizer F, Toniolo P, Willett W, Wolk A, Zeleniuch‐Jacquotte A, Hunter D. Types of dietary fat and breast cancer: A pooled analysis of cohort studies. International Journal Of Cancer 2001, 92: 767-774. PMID: 11340585, DOI: 10.1002/1097-0215(20010601)92:5<767::aid-ijc1247>3.0.co;2-0.Peer-Reviewed Original ResearchConceptsType of fatBreast cancer riskRelative riskCancer riskIncident invasive breast cancer casesStudy-specific relative risksInvasive breast cancer casesCarbohydrate consumptionVegetable fat intakePooled relative riskBreast cancer casesEquivalent energy intakeRandom-effects modelWeak positive associationCohort studyMenopausal statusFat intakeProspective studyPooled analysisDietary fatBreast cancerCancer casesPooled databaseEnergy intakeIntakeIntake of Fruits and Vegetables and Risk of Breast Cancer: A Pooled Analysis of Cohort Studies
Smith-Warner SA, Spiegelman D, Yaun SS, Adami HO, Beeson WL, van den Brandt PA, Folsom AR, Fraser GE, Freudenheim JL, Goldbohm RA, Graham S, Miller AB, Potter JD, Rohan TE, Speizer FE, Toniolo P, Willett WC, Wolk A, Zeleniuch-Jacquotte A, Hunter DJ. Intake of Fruits and Vegetables and Risk of Breast Cancer: A Pooled Analysis of Cohort Studies. JAMA 2001, 285: 769-776. PMID: 11176915, DOI: 10.1001/jama.285.6.769.Peer-Reviewed Original ResearchConceptsBreast cancer casesBreast cancerRelative riskCancer casesVegetable consumptionSpecific fruitsIncident invasive breast cancer casesIncident breast cancer casesStudy-specific relative risksInvasive breast cancer casesTotal fruitIntake of fruitsUsual dietary intakeBreast cancer riskCase-control studyDiet assessment methodsRandom-effects modelCohort studyTotal vegetablesExposure definitionGroup intakesProspective studyGreen leafy vegetablesPooled analysisDietary intakeProspective study of dietary fat and the risk of age-related macular degeneration 1 , 2 , 3
Cho E, Hung S, Willett W, Spiegelman D, Rimm E, Seddon J, Colditz G, Hankinson S. Prospective study of dietary fat and the risk of age-related macular degeneration 1 , 2 , 3. American Journal Of Clinical Nutrition 2001, 73: 209-218. PMID: 11157315, DOI: 10.1093/ajcn/73.2.209.Peer-Reviewed Original ResearchConceptsAge-related macular degenerationRisk of AMDTotal fat intakeFat intakeRelative riskHealth StudyPooled multivariate relative risksDiagnosis of AMDFish/wkModest inverse relationServings/moHealth Professionals FollowMultivariate relative riskNurses' Health StudyFood frequency questionnaireProfessionals FollowStudy of participantsProspective followVisual lossProspective studyLowest quintileDietary fatMacular degenerationHigh intakeLinolenic acidDietary and lifestyle factors in relation to plasma leptin concentrations among normal weight and overweight men
Chu N, Stampfer M, Spiegelman D, Rifai N, Hotamisligil G, Rimm E. Dietary and lifestyle factors in relation to plasma leptin concentrations among normal weight and overweight men. International Journal Of Obesity 2001, 25: 106-114. PMID: 11244465, DOI: 10.1038/sj.ijo.0801468.Peer-Reviewed Original ResearchConceptsBody mass indexPlasma leptin concentrationsLow plasma leptin concentrationsBody fat massLeptin concentrationsPhysical activityNormal weightOverweight menFat intakeLifestyle factorsFat massBlood samplesConfounding variablesWeight gainMonounsaturated fat intakeY weight gainRecent prospective studiesVenous blood samplesCurrent smokingObese menCholesterol intakeObese subjectsMass indexPlasma leptinProspective study
2000
Prospective Study of Dietary Supplements, Macronutrients, Micronutrients, and Risk of Bladder Cancer in US Men
Michaud DS, Spiegelman D, Clinton SK, Rimm EB, Willett WC, Giovannucci E. Prospective Study of Dietary Supplements, Macronutrients, Micronutrients, and Risk of Bladder Cancer in US Men. American Journal Of Epidemiology 2000, 152: 1145-1153. PMID: 11130620, DOI: 10.1093/aje/152.12.1145.Peer-Reviewed Original ResearchConceptsBladder cancer riskBladder cancerSupplement useBladder carcinogenesisCancer riskTotal vitamin E intakeVitamin C supplement useVitamin E supplement useSuggestive inverse associationFood frequency questionnaireVitamin E intakeFourth leading causeVitamin E supplementsIntake of macroProspective Health ProfessionalsDose-response relationFrequency questionnaireE intakeE supplementsProspective studyInverse associationDietary intakeLeading causeMacronutrient intakeDietary variablesProspective study of major dietary patterns and risk of coronary heart disease in men 1 , 2 , 3
Hu F, Rimm E, Stampfer M, Ascherio A, Spiegelman D, Willett W. Prospective study of major dietary patterns and risk of coronary heart disease in men 1 , 2 , 3. American Journal Of Clinical Nutrition 2000, 72: 912-921. PMID: 11010931, DOI: 10.1093/ajcn/72.4.912.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAlcohol DrinkingBody Mass IndexCohort StudiesCoronary DiseaseDietDiet RecordsDietary SupplementsExerciseFactor Analysis, StatisticalHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionProportional Hazards ModelsProspective StudiesRisk FactorsSmokingSurveys and QuestionnairesConceptsCoronary heart diseaseFood frequency questionnaireMajor dietary patternsRisk of CHDDietary patternsHeart diseaseRelative riskHigh intakePattern scoresCases of CHDHigh-fat dairy productsPrudent pattern scoresWestern pattern scoreCHD risk factorsProspective cohort studyOverall dietary patternsBody mass indexPrudent patternCohort studyCigarette smokingMass indexProspective studyHighest quintileMyocardial infarctionSubgroup analysisA prospective study of the effect of alcohol consumption and ADH3 genotype on plasma steroid hormone levels and breast cancer risk.
Hines LM, Hankinson SE, Smith-Warner SA, Spiegelman D, Kelsey KT, Colditz GA, Willett WC, Hunter DJ. A prospective study of the effect of alcohol consumption and ADH3 genotype on plasma steroid hormone levels and breast cancer risk. Cancer Epidemiology Biomarkers & Prevention 2000, 9: 1099-105. PMID: 11045794.Peer-Reviewed Original ResearchConceptsBreast cancer riskAlcohol dehydrogenase type 3Hormone levelsCancer riskSteroid hormone levelsAlcohol intakeAlcohol consumptionADH3 genotypeHealth StudyADH3 polymorphismIncident breast cancer casesSex hormone-binding globulinOverall breast cancer riskPlasma steroid hormone levelsNurses' Health StudyHormone-binding globulinPartial Pearson correlation coefficientsCase-control studyConditional logistic regressionBreast cancer casesPostmenopausal womenProspective studyDehydroepiandrosterone sulfateRelative riskBreast cancerProspective Study of Alcohol Consumption and the Risk of Age-Related Macular Degeneration
Cho E, Hankinson SE, Willett WC, Stampfer MJ, Spiegelman D, Speizer FE, Rimm EB, Seddon JM. Prospective Study of Alcohol Consumption and the Risk of Age-Related Macular Degeneration. JAMA Ophthalmology 2000, 118: 681-688. PMID: 10815161, DOI: 10.1001/archopht.118.5.681.Peer-Reviewed Original ResearchConceptsAge-related macular degenerationRisk of AMDProspective studyMacular degenerationAlcohol consumptionRelative riskDiagnosis of AMDSemiquantitative food frequency questionnaireMale health professionalsPooled relative riskFood frequency questionnaireModerate alcohol consumptionVisual acuity lossConfidence intervalsRisk of AgeRelationship of alcoholYears of ageAlcohol intakeAcuity lossRisk factorsPooled estimatesFemale nursesHealth professionalsAdditional subjectsWomen
1999
A prospective study of carotenoid intake and risk of cataract extraction in US men
Brown L, Rimm E, Seddon J, Giovannucci E, Chasan-Taber L, Spiegelman D, Willett W, Hankinson S. A prospective study of carotenoid intake and risk of cataract extraction in US men. American Journal Of Clinical Nutrition 1999, 70: 517-524. PMID: 10500021, DOI: 10.1093/ajcn/70.4.517.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAlcohol DrinkingBeta CaroteneBrassicaCarotenoidsCataractCataract ExtractionCohort StudiesDiabetes ComplicationsDiet SurveysHumansLuteinMaleMiddle AgedMultivariate AnalysisProspective StudiesRisk FactorsSmokingSpinacia oleraceaSurveys and QuestionnairesUnited StatesVitamin AXanthophyllsZeaxanthinsConceptsCataract extractionLower riskUS male health professionalsDetailed dietary questionnairesMale health professionalsProspective epidemiologic dataProspective cohort studyIntake of carotenoidsRisk of cataractPotential risk factorsAge-related cataractSenile cataract extractionDietary questionnaireCohort studyZeaxanthin intakeHighest fifthProspective studyRisk factorsEpidemiologic dataHigh intakeCarotenoid intakeUS menDietary antioxidantsVitamin AHealth professionals