2004
A Randomized Trial of Multivitamin Supplements and HIV Disease Progression and Mortality
Fawzi WW, Msamanga GI, Spiegelman D, Wei R, Kapiga S, Villamor E, Mwakagile D, Mugusi F, Hertzmark E, Essex M, Hunter DJ. A Randomized Trial of Multivitamin Supplements and HIV Disease Progression and Mortality. New England Journal Of Medicine 2004, 351: 23-32. PMID: 15229304, DOI: 10.1056/nejmoa040541.Peer-Reviewed Original ResearchConceptsVitamin AHIV diseaseMultivitamin supplementsHuman immunodeficiency virus (HIV) diseasePlacebo-controlled trialHIV disease progressionStage 4 diseaseLow viral loadHigher CD4Antiretroviral therapyPrimary outcomeImmunodeficiency syndromeRandomized trialsViral loadPregnant womenDisease progressionRelative riskObservational studyDaily supplementCell countEnd pointMicronutrient statusMultivitaminsDiseaseProgression
2003
Effect of Providing Vitamin Supplements to Human Immunodeficiency Virus-Infected, Lactating Mothers on the Child's Morbidity and CD4+ Cell Counts
Fawzi WW, Msamanga GI, Wei R, Spiegelman D, Antelman G, Villamor E, Manji K, Hunter D. Effect of Providing Vitamin Supplements to Human Immunodeficiency Virus-Infected, Lactating Mothers on the Child's Morbidity and CD4+ Cell Counts. Clinical Infectious Diseases 2003, 36: 1053-1062. PMID: 12684919, DOI: 10.1086/374223.Peer-Reviewed Original ResearchConceptsMultivitamin armCell countVitamin AHuman immunodeficiency virus type 1Immunodeficiency virus type 1Placebo-controlled trialCells/microLHIV-negative childrenHIV-positive childrenHuman immunodeficiency virusChildren of womenRapid respiratory rateVirus type 1Low-cost interventionEffect of supplementationMaternal receiptMean CD4Immunodeficiency virusMultivitamin supplementsChild morbidityChild healthVitamin supplementsLower riskRespiratory rateType 1
2002
Effect of multivitamin and vitamin A supplements on weight gain during pregnancy among HIV-1-infected women 1 , 2 , 3
Villamor E, Msamanga G, Spiegelman D, Antelman G, Peterson KE, Hunter DJ, Fawzi WW. Effect of multivitamin and vitamin A supplements on weight gain during pregnancy among HIV-1-infected women 1 , 2 , 3. American Journal Of Clinical Nutrition 2002, 76: 1082-1090. PMID: 12399282, DOI: 10.1093/ajcn/76.5.1082.Peer-Reviewed Original ResearchConceptsEffects of multivitaminsThird trimesterWeight gainVitamin AMultivitamin supplementationSecond trimesterHIV-1-positive womenAdverse pregnancy outcomesPlacebo-controlled trialGestational weight gainHIV-positive womenEnd of pregnancyPregnancy outcomesOral supplementsAverage weight gainProtective effectTrimesterLower weight gainMultivitaminsPregnancyWomen 1HIVWomenDar es SalaamLower rates
2000
Vitamin A supplements and diarrheal and respiratory tract infections among children in Dar es Salaam, Tanzania
Fawzi W, Mbise R, Spiegelman D, Fataki M, Hertzmark E, Ndossi G. Vitamin A supplements and diarrheal and respiratory tract infections among children in Dar es Salaam, Tanzania. The Journal Of Pediatrics 2000, 137: 660-667. PMID: 11060532, DOI: 10.1067/mpd.2000.110136.Peer-Reviewed Original ResearchConceptsRespiratory tract infectionsHuman immunodeficiency virusTract infectionsVitamin APlacebo-controlled trialAcute respiratory infectionsSevere watery diarrheaRisk of diarrheaEffect of vitaminDuration of episodesRapid respiratory rateLow-cost interventionAcute diarrheaRespiratory infectionsImmunodeficiency virusWatery diarrheaAdverse outcomesUndernourished childrenHigh riskDiarrheaRespiratory rateInfectionSmall riskPlaceboDar es SalaamVitamin A supplementation and other predictors of anemia among children from Dar Es Salaam, Tanzania.
Villamor E, Mbise R, Spiegelman D, Ndossi G, Fawzi WW. Vitamin A supplementation and other predictors of anemia among children from Dar Es Salaam, Tanzania. American Journal Of Tropical Medicine And Hygiene 2000, 62: 590-7. PMID: 11289670, DOI: 10.4269/ajtmh.2000.62.590.Peer-Reviewed Original ResearchConceptsSevere anemiaHemoglobin levelsHuman immunodeficiency virus (HIV) infectionPredictors of anemiaPlacebo-controlled trialImmunodeficiency virus infectionMean hemoglobin levelAssociation of hemoglobinMonths of breastfeedingDiagnosis of malariaYears of agePotential confounding variablesMonth old infantsLow socioeconomic statusHIV infectionIndependent determinantsMalaria infectionMaternal levelsAdditional dosesNonsignificant reductionHematologic profileVirus infectionSignificant fallHemoglobin concentrationVitamin ARandomized Trial of Vitamin Supplements in Relation to Vertical Transmission of HIV-1 in Tanzania
Fawzi W, Msamanga G, Hunter D, Urassa E, Renjifo B, Mwakagile D, Hertzmark E, Coley J, Garland M, Kapiga S, Antelman G, Essex M, Spiegelman D. Randomized Trial of Vitamin Supplements in Relation to Vertical Transmission of HIV-1 in Tanzania. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 23: 246-254. DOI: 10.1097/00126334-200003010-00005.Peer-Reviewed Original ResearchPregnant womenPolymerase chain reactionVitamin APlacebo-controlled trialPoor nutritional statusMultivitamin armHIV infectionHIV statusWeeks postpartumObservational studyHIV-1High riskHIVNutritional statusEffects of supplementsVertical transmissionChain reactionBirthMultivitaminsBabiesWomenSupplementsVitaminArmStatusRandomized trial of vitamin supplements in relation to vertical transmission of HIV-1 in Tanzania.
Fawzi W, Msamanga G, Hunter D, Urassa E, Renjifo B, Mwakagile D, Hertzmark E, Coley J, Garland M, Kapiga S, Antelman G, Essex M, Spiegelman D. Randomized trial of vitamin supplements in relation to vertical transmission of HIV-1 in Tanzania. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 23: 246-54. PMID: 10839660, DOI: 10.1097/00126334-200003010-00006.Peer-Reviewed Original ResearchConceptsPregnant womenPolymerase chain reactionVitamin APlacebo-controlled trialPoor nutritional statusMultivitamin armHIV infectionHIV statusWeeks postpartumObservational studyHIV-1High riskHIVNutritional statusEffects of supplementsVertical transmissionChain reactionBirthMultivitaminsBabiesWomenSupplementsVitaminArmStatusRandomized Trial of Vitamin Supplements in Relation to Vertical Transmission of HIV-1 in Tanzania
Fawzi W, Msamanga G, Hunter D, Urassa E, Renjifo B, Mwakagile D, Hertzmark E, Coley J, Garland M, Kapiga S, Antelman G, Essex M, Spiegelman D. Randomized Trial of Vitamin Supplements in Relation to Vertical Transmission of HIV-1 in Tanzania. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 23: 246-254. DOI: 10.1097/00042560-200003010-00006.Peer-Reviewed Original ResearchConceptsPregnant womenPolymerase chain reactionVitamin APlacebo-controlled trialPoor nutritional statusBackground Observational studiesMultivitamin armHIV infectionHIV statusWeeks postpartumObservational studyHIV-1High riskHIVNutritional statusEffects of supplementsVertical transmissionChain reactionBirthMultivitaminsBabiesWomenSupplementsVitaminArm
1999
Rationale and Design of the Tanzania Vitamin and HIV Infection Trial
Fawzi W, Msamanga G, Spiegelman D, Urassa E, Hunter D. Rationale and Design of the Tanzania Vitamin and HIV Infection Trial. Contemporary Clinical Trials 1999, 20: 75-90. PMID: 10027501, DOI: 10.1016/s0197-2456(98)00045-2.Peer-Reviewed Original ResearchConceptsHIV infectionVitamin APregnant womenPolymerase chain reactionVitamin supplementsHIV-positive pregnant womenVertical transmissionHIV Infection TrialInfant immune functionEligible pregnant womenPlacebo-controlled trialClinical staging systemHIV-positive womenGenital tract secretionsUse of supplementsHIV diseaseMost HIVPrevention trialsViral loadMain endpointBreast milkStaging systemCohort retentionPosttest counselingTract secretionsA randomized trial of vitamin A supplements in relation to mortality among human immunodeficiency virus-infected and uninfected children in Tanzania
FAWZI W, MBISE R, HERTZMARK E, FATAKI M, HERRERA M, NDOSSI G, SPIEGELMAN D. A randomized trial of vitamin A supplements in relation to mortality among human immunodeficiency virus-infected and uninfected children in Tanzania. The Pediatric Infectious Disease Journal 1999, 18: 127-133. PMID: 10048684, DOI: 10.1097/00006454-199902000-00009.Peer-Reviewed Original ResearchConceptsUninfected childrenCause mortalityChildren ages 6 monthsMortality of HIVTrial of vitaminPlacebo-controlled trialDiarrhea-related deathsAge 6 monthsWestern blot testMonths of ageEnzyme-linked immunosorbentLow-cost interventionChildren 58HIV antibodiesHospital dischargeHIV infectionHIV statusPositive childrenStandard treatmentMean durationAntigen assaysFurther dosesHuman immunodeficiencyClinical signsNeutralization assays
1998
Vitamin A supplementation and severity of pneumonia in children admitted to the hospital in Dar es Salaam, Tanzania 1 2 3
Fawzi WW, Mbise RL, Fataki MR, Herrera MG, Kawau F, Hertzmark E, Spiegelman D, Ndossi G. Vitamin A supplementation and severity of pneumonia in children admitted to the hospital in Dar es Salaam, Tanzania 1 2 3. American Journal Of Clinical Nutrition 1998, 68: 187-192. PMID: 9665113, DOI: 10.1093/ajcn/68.1.187.Peer-Reviewed Original ResearchConceptsVitamin APlacebo groupTanzanian childrenLarge dosesAcute lower respiratory tract infectionLower respiratory tract infectionsImportant public health problemPlacebo-controlled trialRespiratory tract infectionsDay of admissionSeverity of pneumoniaBreast-feeding statusCourse of pneumoniaSevere clinical conditionMean numberPublic health problemRapid respiratory rateHospital stayTract infectionsDietary vitaminClinical conditionsProtective effectRespiratory diseaseHealth problemsNutritional statusRandomised trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1-infected women in Tanzania
Fawzi W, Msamanga G, Spiegelman D, Urassa E, McGrath N, Mwakagile D, Antelman G, Mbise R, Kapiga S, Willett W, Hunter D, Team F, Herrera G. Randomised trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1-infected women in Tanzania. The Lancet 1998, 351: 1477-1482. PMID: 9605804, DOI: 10.1016/s0140-6736(98)04197-x.Peer-Reviewed Original ResearchConceptsHIV-1-infected womenT-cell countsHIV-1 diseaseBirth outcomesVitamin APregnancy outcomesMultivitamin supplementationHIV-1-infected pregnant womenPoor micronutrient statusTrial of effectAdverse pregnancy outcomesPlacebo-controlled trialT lymphocyte subsetsAdverse birth outcomesEffects of multivitaminsSevere preterm birthsLymphocyte subsetsPreterm birthFetal deathWeeks' gestationGestational ageClinical progressionPregnant womenLow birthweightFaster progression