2020
Vitamin D Supplements for Prevention of Tuberculosis Infection and Disease
Ganmaa D, Uyanga B, Zhou X, Gantsetseg G, Delgerekh B, Enkhmaa D, Khulan D, Ariunzaya S, Sumiya E, Bolortuya B, Yanjmaa J, Enkhtsetseg T, Munkhzaya A, Tunsag M, Khudyakov P, Seddon JA, Marais BJ, Batbayar O, Erdenetuya G, Amarsaikhan B, Spiegelman D, Tsolmon J, Martineau AR. Vitamin D Supplements for Prevention of Tuberculosis Infection and Disease. New England Journal Of Medicine 2020, 383: 359-368. PMID: 32706534, PMCID: PMC7476371, DOI: 10.1056/nejmoa1915176.Peer-Reviewed Original ResearchConceptsVitamin D groupAcute respiratory infectionsVitamin D supplementationPlacebo groupRespiratory infectionsTuberculosis infectionD groupVitamin DTuberculosis diseaseD supplementationAdverse eventsQFT resultsPositive QFT resultWeekly oral doseVitamin D supplementsQuantiFERON-TB GoldProportion of childrenD supplementsSecondary outcomesPrimary outcomeOral doseD levelsImmune responseLower riskInfection
2014
The effects of multivitamin and zinc supplementation on infectious morbidity in Tanzanian infants (389.5)
McDonald C, Manji K, Kisenge R, Aboud S, Spiegelman D, Fawzi W, Duggan C. The effects of multivitamin and zinc supplementation on infectious morbidity in Tanzanian infants (389.5). The FASEB Journal 2014, 28 DOI: 10.1096/fasebj.28.1_supplement.389.5.Peer-Reviewed Original ResearchUpper respiratory infectionAge 6 weeksInfectious morbidityTanzanian infantsRespiratory infectionsZinc supplementationMonthly visitsAcute upper respiratory infectionHIV-negative mothersBurden of diarrheaDaily oral supplementationDaily zinc supplementationEffects of multivitaminsRate of diarrheaIncidence of diarrheaNon-significant increasePlacebo groupStudy nursesStudy physiciansOral supplementationOutpatient visitsDaily supplementationMultivitaminsMorbidityInfants
2013
Micronutrient supplementation and T cell-mediated immune responses in patients with tuberculosis in Tanzania
KAWAI K, MEYDANI SN, URASSA W, WU D, MUGUSI FM, SAATHOFF E, BOSCH RJ, VILLAMOR E, SPIEGELMAN D, FAWZI WW. Micronutrient supplementation and T cell-mediated immune responses in patients with tuberculosis in Tanzania. Epidemiology And Infection 2013, 142: 1505-1509. PMID: 24093552, PMCID: PMC5639693, DOI: 10.1017/s0950268813002495.Peer-Reviewed Original ResearchConceptsCell-mediated immune responsesTB patientsMicronutrient supplementationMicronutrient supplementsImmune responseProliferative responseT cell-mediated immune responsesHIV-negative TB patientsHIV-positive TB patientsLymphocyte proliferative responsesLymphocyte proliferation responseHigher proliferative responsesT cell mitogensPlacebo groupPulmonary TBTB treatmentDaily doseEligible participantsNutritional interventionTuberculosis treatmentTime of initiationClinical relevanceMicronutrient groupProliferation responsePatients
2007
Vitamins and Perinatal Outcomes Among HIV-Negative Women in Tanzania
Fawzi W, Msamanga G, Urassa W, Hertzmark E, Petraro P, Willett W, Spiegelman D. Vitamins and Perinatal Outcomes Among HIV-Negative Women in Tanzania. Obstetrical & Gynecological Survey 2007, 62: 561-563. DOI: 10.1097/01.ogx.0000279296.97522.77.Peer-Reviewed Original ResearchLow birth weightGestational age infantsHIV-negative womenMultivitamin groupBirth weightRelative riskPlacebo groupPreterm birthFetal deathGestational ageMultivitamin supplementsPregnant womenMicronutrient statusDouble-blind trialFolic acidMean birth weightSimilar baseline characteristicsWeeks gestational ageConfidence intervalsPrenatal vitamin supplementationHigher hemoglobin levelsPlacebo recipientsMaternal anemiaPerinatal outcomesBaseline characteristics
1998
Vitamin A supplementation and severity of pneumonia in children admitted to the hospital in Dar es Salaam, Tanzania 1 2 3
Fawzi WW, Mbise RL, Fataki MR, Herrera MG, Kawau F, Hertzmark E, Spiegelman D, Ndossi G. Vitamin A supplementation and severity of pneumonia in children admitted to the hospital in Dar es Salaam, Tanzania 1 2 3. American Journal Of Clinical Nutrition 1998, 68: 187-192. PMID: 9665113, DOI: 10.1093/ajcn/68.1.187.Peer-Reviewed Original ResearchConceptsVitamin APlacebo groupTanzanian childrenLarge dosesAcute lower respiratory tract infectionLower respiratory tract infectionsImportant public health problemPlacebo-controlled trialRespiratory tract infectionsDay of admissionSeverity of pneumoniaBreast-feeding statusCourse of pneumoniaSevere clinical conditionMean numberPublic health problemRapid respiratory rateHospital stayTract infectionsDietary vitaminClinical conditionsProtective effectRespiratory diseaseHealth problemsNutritional status