2020
Erythrocyte membrane fatty acids and breast cancer risk by tumor tissue expression of immuno-inflammatory markers and fatty acid synthase: a nested case-control study
McGee EE, Kim CH, Wang M, Spiegelman D, Stover DG, Heng YJ, Collins LC, Baker GM, Farvid MS, Schedin P, Jindal S, Tamimi RM, Eliassen AH. Erythrocyte membrane fatty acids and breast cancer risk by tumor tissue expression of immuno-inflammatory markers and fatty acid synthase: a nested case-control study. Breast Cancer Research 2020, 22: 78. PMID: 32698885, PMCID: PMC7374956, DOI: 10.1186/s13058-020-01316-4.Peer-Reviewed Original ResearchConceptsBreast cancer riskImmuno-inflammatory markersErythrocyte membrane fatty acidsCase-control studyTumor tissue expressionFatty acid synthaseCancer riskTrans fatty acidsExpression subtypesOdds ratioSpecific fatty acidsLogistic regressionHealth Study IITumor tissue blocksMembrane fatty acidsFatty acidsUnconditional logistic regressionConfidence intervalsTissue expressionT cell functionPolytomous logistic regressionAcid synthaseTumor CD4Potential confoundersTumor expression
2003
A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk.
Han J, Hankinson SE, De Vivo I, Spiegelman D, Tamimi RM, Mohrenweiser HW, Colditz GA, Hunter DJ. A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk. Cancer Research 2003, 63: 8536-41. PMID: 14679022.Peer-Reviewed Original ResearchConceptsBreast cancer riskBeta-carotene levelsCancer riskInverse associationHealth StudyXRCC1 geneNurses' Health StudyMultivariate odds ratiosCase-control studyPotential protective effectPresent study populationHaplotype-tagging single nucleotide polymorphismsXRCC1 haplotypesCigarette smokingProspective studyCaucasian womenEffect modificationOdds ratioBreast cancerProtective effectStudy populationOxidative DNA damageBreast carcinogenesisGene-environment interactionsPlasma carotenoidsHigh 18:2 Trans-Fatty Acids in Adipose Tissue Are Associated with Increased Risk of Nonfatal Acute Myocardial Infarction in Costa Rican Adults
Baylin A, Kabagambe EK, Ascherio A, Spiegelman D, Campos H. High 18:2 Trans-Fatty Acids in Adipose Tissue Are Associated with Increased Risk of Nonfatal Acute Myocardial Infarction in Costa Rican Adults. Journal Of Nutrition 2003, 133: 1186-1191. PMID: 12672941, DOI: 10.1093/jn/133.4.1186.Peer-Reviewed Original ResearchConceptsRisk of MICoronary heart diseaseMyocardial infarctionAdipose tissueTrans fatty acidsOdds ratioNonfatal acute myocardial infarctionTrans fatty acid intakeFirst nonfatal myocardial infarctionConditional logistic regression modelsNonfatal myocardial infarctionTrans FACosta Rican adultsAcute myocardial infarctionTotal adipose tissueAdipose tissue samplesArea of residenceIndividual trans fatty acidsLogistic regression modelsIncreased riskIncident casesAcid intakeRisk factorsAtherogenic potentialHeart disease
2002
Dietary and Adipose Tissue Gamma-Tocopherol and Risk of Myocardial Infarction
El-Sohemy A, Baylin A, Spiegelman D, Ascherio A, Campos H. Dietary and Adipose Tissue Gamma-Tocopherol and Risk of Myocardial Infarction. Epidemiology 2002, 13: 216-223. PMID: 11880764, DOI: 10.1097/00001648-200203000-00018.Peer-Reviewed Original ResearchConceptsDietary vitamin EMyocardial infarctionGamma-tocopherolOdds ratioVitamin ENonfatal myocardial infarctionFood frequency questionnaireCoronary heart diseasePopulation-based studyFirst myocardial infarctionConfidence intervalsConditional logistic regressionAdipose tissue samplesHighest quintileSupplement usersLowest quintileHeart diseaseInverse associationDietary intakeLower riskSubstantial inverse associationMultivariate analysisLogistic regressionTissue samplesWeak association
1999
Design of Validation Studies for Estimating the Odds Ratio of Exposure–Disease Relationships When Exposure is Misclassified
Holcroft C, Spiegelman D. Design of Validation Studies for Estimating the Odds Ratio of Exposure–Disease Relationships When Exposure is Misclassified. Biometrics 1999, 55: 1193-1201. PMID: 11315067, DOI: 10.1111/j.0006-341x.1999.01193.x.Peer-Reviewed Original ResearchGlutathione S -Transferase Mu and Theta Polymorphisms and Breast Cancer Susceptibility
García-Closas M, Kelsey K, Hankinson S, Spiegelman D, Springer K, Willett W, Speizer F, Hunter D. Glutathione S -Transferase Mu and Theta Polymorphisms and Breast Cancer Susceptibility. Journal Of The National Cancer Institute 1999, 91: 1960-1964. PMID: 10564681, DOI: 10.1093/jnci/91.22.1960.Peer-Reviewed Original ResearchConceptsGlutathione S-transferase mu 1Breast cancer riskBreast cancerGSTT1 null genotypeCancer riskOdds ratioNull genotypeGSTT1 genesConditional logistic regression modelsEndogenous mutagenic processesGlutathione S-transferase muConfidence intervalsGSTT1 gene deletionGSTT1 gene polymorphismsLogistic regression modelsHomozygous gene deletionBreast cancer susceptibilityTheta 1 genePremenopausal womenProspective cohortCigarette smokingIncident casesDecreased riskControl subjectsGSTT1 genotype
1998
Vitamins A, C and E and the risk of breast cancer: results from a case-control study in Greece
Bohlke K, Spiegelman D, Trichopoulou A, Katsouyanni K, Trichopoulos D. Vitamins A, C and E and the risk of breast cancer: results from a case-control study in Greece. British Journal Of Cancer 1998, 79: 23-29. PMID: 10408688, PMCID: PMC2362172, DOI: 10.1038/sj.bjc.6690006.Peer-Reviewed Original ResearchConceptsΒ-carotene intakeBreast cancer riskCase-control studyBreast cancerOdds ratioCancer riskVitamin ESemiquantitative food frequency questionnaireBreast cancer risk factorsIntake of retinolVitamin CFood frequency questionnaireCancer risk factorsPost-menopausal womenTotal energy intakeΒ-carotene effectPremenopausal womenFrequency questionnaireControl womenVegetable intakeInverse associationRisk factorsDietary compoundsDietary dataSpecific micronutrientsUse of Toenail Fluoride Levels as an Indicator for the Risk of Hip and Forearm Fractures in Women
Feskanich D, Owusu W, Hunter D, Willett W, Ascherio A, Spiegelman D, Morris S, Spate V, Colditz G. Use of Toenail Fluoride Levels as an Indicator for the Risk of Hip and Forearm Fractures in Women. Epidemiology 1998, 9: 412-416. PMID: 9647905, DOI: 10.1097/00001648-199807000-00011.Peer-Reviewed Original ResearchConceptsForearm fracturesFluoride intakeOdds ratioHealth StudyVitamin D intakeDistal forearm fracturesNurses' Health StudyRisk of hipPostmenopausal hormone useBody mass indexLong-term intakeYear of birthD intakeMenopausal statusHip fractureHormone useHighest quartileMass indexOsteoporotic fracturesSmoking statusPrevious hipHeart diseaseSubsequent riskCaffeine intakeEpidemiologic studies
1997
Glutathione S-transferase class mu deletion polymorphism and breast cancer: results from prevalent versus incident cases.
Kelsey KT, Hankinson SE, Colditz GA, Springer K, Garcia-Closas M, Spiegelman D, Manson JE, Garland M, Stampfer MJ, Willett WC, Speizer FE, Hunter DJ. Glutathione S-transferase class mu deletion polymorphism and breast cancer: results from prevalent versus incident cases. Cancer Epidemiology Biomarkers & Prevention 1997, 6: 511-5. PMID: 9232338.Peer-Reviewed Original ResearchConceptsBreast cancerGene deletion polymorphismCase seriesDeletion polymorphismHealth StudyNull genotypeGSTM1 deletionGlutathione S-transferase class muPrevalent breast cancerIncident breast cancerNurses' Health StudyGSTM1 gene deletion polymorphismBreast cancer riskDuration of survivalAge-matched controlsGSTM1 null genotypeBreast cancer prognosisMolecular epidemiologic studiesImproved survivalCigarette smokingIncident casesOdds ratioPrevalent casesEpidemiologic studiesCancer riskRegression calibration method for correcting measurement-error bias in nutritional epidemiology
Spiegelman D, McDermott A, Rosner B. Regression calibration method for correcting measurement-error bias in nutritional epidemiology. American Journal Of Clinical Nutrition 1997, 65: s1179-s1186. PMID: 9094918, DOI: 10.1093/ajcn/65.4.1179s.Peer-Reviewed Original ResearchConceptsHealth StudyDietary intakeMassachusetts Women's Health StudyUltradistal radius bone densityCox proportional hazards modelRadius bone densityNurses' Health StudyWomen's Health StudyIncidence rate ratiosRate ratioProportional hazards modelOdds ratioBone densityBreast cancerHazards modelVitamin ANutritional epidemiologyLogistic regressionGold standardLinear regression modelsEpidemiologyIntakeRegression modelsValidation studyPerson error
1996
Birth weight and adult hypertension, diabetes mellitus, and obesity in US men.
Curhan G, Willett W, Rimm E, Spiegelman D, Ascherio A, Stampfer M. Birth weight and adult hypertension, diabetes mellitus, and obesity in US men. Circulation 1996, 94: 3246-50. PMID: 8989136, DOI: 10.1161/01.cir.94.12.3246.Peer-Reviewed Original ResearchConceptsAge-adjusted odds ratioAdult body mass indexLow birth weightBody mass indexDiabetes mellitusBirth weightAdult hypertensionMass indexOdds ratioChronic diseasesUS menChronic adult diseasesBirth weight categoriesDependent diabetes mellitusPrevalence of obesityRisk of hypertensionRisk of obesityHigh birth weightEarly life exposureCumulative incidenceLowest quintileMedical historyRisk factorsFamily historyLife exposureHuman Immunodeficiency Virus Infection in Mexico City
Coplan P, Gortmaker S, Hemandez-Avila M, Spiegelman D, Uribe-Zuūiga P, Mueller N. Human Immunodeficiency Virus Infection in Mexico City. American Journal Of Epidemiology 1996, 144: 817-827. PMID: 8890660, DOI: 10.1093/oxfordjournals.aje.a009016.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virus (HIV) infectionRectal bleedingImmunodeficiency virus infectionAnal wartsHIV infectionAnal intercourseRisk factorsVirus infectionIndependent risk factorReceptive anal intercourseLogistic regression modelingAnonymous HIVIntercourse episodesGenital ulcersHIV seroprevalenceHIV serostatusInsertive intercourseHIV transmissionOdds ratioBleedingEligible clientsPublic clinicsMultivariate analysisInfectionOlder ageA methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer.
Chen J, Giovannucci E, Kelsey K, Rimm EB, Stampfer MJ, Colditz GA, Spiegelman D, Willett WC, Hunter DJ. A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer. Cancer Research 1996, 56: 4862-4. PMID: 8895734.Peer-Reviewed Original ResearchConceptsVal/Val individualsVal/Val genotypeColorectal cancerOdds ratioVal genotypeHealth Professionals FollowColorectal cancer riskStrong risk factorHigh dietary intakeCase-control studyMore alcoholic drinksMethylenetetrahydrofolate reductase (MTHFR) polymorphismsVariant homozygous genotypeMethylenetetrahydrofolate reductase (MTHFR) geneProfessionals FollowAlcohol intakeInverse associationRisk factorsDietary intakeReduced incidenceMTHFR genotypeCancer riskBlood samplesAlcohol consumptionOncogenic alterationsBirth weight and adult hypertension and obesity in women.
Curhan G, Chertow G, Willett W, Spiegelman D, Colditz G, Manson J, Speizer F, Stampfer M. Birth weight and adult hypertension and obesity in women. Circulation 1996, 94: 1310-5. PMID: 8822985, DOI: 10.1161/01.cir.94.6.1310.Peer-Reviewed Original ResearchConceptsAge-adjusted odds ratioHealth Study IIBody mass indexBirth weightYears of ageOdds ratioNHS IMass indexNurses' Health Study INurses' Health Study IIAdult body mass indexHealth Study INHS II cohortDevelopment of hypertensionLow birth weightPhysician-diagnosed hypertensionRisk of hypertensionHigh birth weightEarly life exposureAdult hypertensionNHS IIBlood pressureLowest quintileRisk factorsLife exposure
1992
Correction of Logistic Regression Relative Risk Estimates and Confidence Intervals for Random Within-Person Measurement Error
Rosner B, Spiegelman D, Willett WC. Correction of Logistic Regression Relative Risk Estimates and Confidence Intervals for Random Within-Person Measurement Error. American Journal Of Epidemiology 1992, 136: 1400-1413. PMID: 1488967, DOI: 10.1093/oxfordjournals.aje.a116453.Peer-Reviewed Original ResearchConceptsRelative risk estimatesRisk factorsLogistic regressionRisk estimatesCoronary risk factorsCoronary heart diseaseGold standardConfidence intervalsFramingham Heart StudyExamination 4Extreme quintilesHeart diseaseOdds ratioHeart StudyExamination 2Exposure assessmentSubstudyCovariatesMenMain studyReproducibility dataRegressionFactorsQuintileIncidence