2022
Cardiovascular Risk Factors Mediate the Long-Term Maternal Risk Associated With Hypertensive Disorders of Pregnancy
Stuart JJ, Tanz LJ, Rimm EB, Spiegelman D, Missmer SA, Mukamal KJ, Rexrode KM, Rich-Edwards JW. Cardiovascular Risk Factors Mediate the Long-Term Maternal Risk Associated With Hypertensive Disorders of Pregnancy. Journal Of The American College Of Cardiology 2022, 79: 1901-1913. PMID: 35550687, PMCID: PMC9176211, DOI: 10.1016/j.jacc.2022.03.335.Peer-Reviewed Original ResearchConceptsCVD risk factorsRates of CVDHealth Study IIRisk of CVDBody mass indexGestational hypertensionType 2 diabetesRisk factorsChronic hypertensionHypertensive disordersMass indexNurses' Health Study IIPrepregnancy body mass indexHistory of HDPCardiovascular risk factorsOverweight/obesityProportional hazards modelIncident CVDCVD preventionNormotensive pregnanciesFirst pregnancyPotential confoundersParental historyHypertensionHazards model
2020
Universal test and treat in relation to HIV disease progression: results from a stepped‐wedge trial in Eswatini
Boeke C, Khan S, Walsh F, Hettema A, Lejeune C, Spiegelman D, Okello V, Harwell J, Mazibuko S, Bärnighausen T. Universal test and treat in relation to HIV disease progression: results from a stepped‐wedge trial in Eswatini. HIV Medicine 2020, 22: 54-59. PMID: 32876360, DOI: 10.1111/hiv.12941.Peer-Reviewed Original ResearchConceptsBody mass indexStepped-wedge trialDisease progressionCD4 countSevere diseaseMultivariate Cox proportional hazards modelWorld Health Organization stageCox proportional hazards modelHIV disease progressionMorbidity/mortalityCells/Proportional hazards modelLower ratesIncident tuberculosisCD4 declineMass indexUniversal testHealth facilitiesBaseline valuesHazards modelHealth outcomesCrowded hospitalsWeight lossProgressionHIVMortality under early access to antiretroviral therapy vs. Eswatini’s national standard of care: the MaxART clustered randomized stepped‐wedge trial
Chao A, Spiegelman D, Khan S, Walsh F, Mazibuko S, Pasipamire M, Chai B, Reis R, Mlambo K, Delva W, Khumalo G, Zwane M, Fleming Y, Mafara E, Hettema A, Lejeune C, Bärnighausen T, Okello V. Mortality under early access to antiretroviral therapy vs. Eswatini’s national standard of care: the MaxART clustered randomized stepped‐wedge trial. HIV Medicine 2020, 21: 429-440. PMID: 32458567, DOI: 10.1111/hiv.12876.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyMortality rateDisease-related mortality rateCox proportional hazards modelCause mortality ratesStepped-wedge trialProportional hazards modelStepped-wedge designQuality of lifeEvidence of harmClinic transitionSecondary outcomesSOC participantsHealth clinicsLong-term consequencesImplementation trialHazards modelHIVStudy participantsMortalityHealth systemDecrease infectionEarly accessClinicTherapy
2009
Intakes of Fruit, Vegetables, and Carotenoids and Renal Cell Cancer Risk: A Pooled Analysis of 13 Prospective Studies
Lee JE, Männistö S, Spiegelman D, Hunter DJ, Bernstein L, van den Brandt PA, Buring JE, Cho E, English DR, Flood A, Freudenheim JL, Giles GG, Giovannucci E, Håkansson N, Horn-Ross PL, Jacobs EJ, Leitzmann MF, Marshall JR, McCullough ML, Miller AB, Rohan TE, Ross JA, Schatzkin A, Schouten LJ, Virtamo J, Wolk A, Zhang SM, Smith-Warner SA. Intakes of Fruit, Vegetables, and Carotenoids and Renal Cell Cancer Risk: A Pooled Analysis of 13 Prospective Studies. Cancer Epidemiology Biomarkers & Prevention 2009, 18: 1730-1739. PMID: 19505906, PMCID: PMC2883186, DOI: 10.1158/1055-9965.epi-09-0045.Peer-Reviewed Original ResearchConceptsPooled multivariate relative risksRenal cell cancerMultivariate relative riskCell cancerRelative riskVegetable consumptionProspective studyPooled analysisStudy-specific relative risksRenal cell cancer riskCox proportional hazards modelFood frequency questionnaireIntake of fruitsLutein/zeaxanthinProportional hazards modelRandom-effects modelTotal vegetablesIncident casesLowest quintileVegetable intakeCancer riskHazards modelCancerTotal fruitRisk
2008
Relations of dietary type of protein, glutamine, and glutamate to the incidence of type 2 diabetes mellitus among middle‐aged women
Lenders C, HU F, Willett W, Douglas W, Sampson L, Dougherty L, Spiegelman D, Liu S. Relations of dietary type of protein, glutamine, and glutamate to the incidence of type 2 diabetes mellitus among middle‐aged women. The FASEB Journal 2008, 22: 299.5-299.5. DOI: 10.1096/fasebj.22.1_supplement.299.5.Peer-Reviewed Original ResearchMiddle-aged womenCereal fiberType 2 diabetes mellitusTotal proteinMultivariate modelModest inverse relationFood frequency questionnaireIncidence of diabetesMajor chronic diseasesProportional hazards modelFrequency questionnaireDiabetes mellitusIncident casesChronic diseasesT2DMDietary habitsHazards modelLifestyle variablesNew casesDietary typesIncidenceWomenInverse relationStudy findingsGlutamine
2005
Fruits and Vegetables and Ovarian Cancer Risk in a Pooled Analysis of 12 Cohort Studies
Koushik A, Hunter DJ, Spiegelman D, Anderson KE, Arslan AA, Beeson WL, van den Brandt PA, Buring JE, Cerhan JR, Colditz GA, Fraser GE, Freudenheim JL, Genkinger JM, Goldbohm RA, Hankinson SE, Koenig KL, Larsson SC, Leitzmann M, McCullough ML, Miller AB, Patel A, Rohan TE, Schatzkin A, Smit E, Willett WC, Wolk A, Zhang SM, Smith-Warner SA. Fruits and Vegetables and Ovarian Cancer Risk in a Pooled Analysis of 12 Cohort Studies. Cancer Epidemiology Biomarkers & Prevention 2005, 14: 2160-2167. PMID: 16172226, DOI: 10.1158/1055-9965.epi-05-0218.Peer-Reviewed Original ResearchConceptsOvarian cancer riskVegetable intakeOvarian cancerCancer riskRelative riskPooled multivariate relative risksStudy-specific relative risksInvasive epithelial ovarian cancerCox proportional hazards modelTotal fruit intakeMultivariate relative riskFood frequency questionnaireTotal vegetable intakeEpithelial ovarian cancerProportional hazards modelDifferent histologic typesRandom-effects modelCancer-preventive actionsCohort studyHistologic typeProspective studyPooled analysisFruit intakeLowest quartileHazards modelHIV-1 Disease Progression and Fertility in Dar es Salaam, Tanzania
Sedgh G, Larsen U, Spiegelman D, Msamanga G, Fawzi WW. HIV-1 Disease Progression and Fertility in Dar es Salaam, Tanzania. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2005, 39: 439-445. PMID: 16010167, DOI: 10.1097/01.qai.0000148529.58963.83.Peer-Reviewed Original ResearchConceptsHIV-1 disease progressionPregnancy rate ratioPregnancy incidenceDisease progressionRate ratioStage IHIV-1-infected womenHIV-1-positive womenCox proportional hazards modelClinical stage IIHIV-1 diseaseProspective cohort studyLive birth rateProportional hazards modelDar es SalaamLive birth incidenceCohort studyMenstrual dysfunctionIndependent predictorsRecent pregnancyHIV statusClinical progressionPregnancy rateOlder womenHazards model
2004
Reproductive History and Endometriosis Among Premenopausal Women
Missmer SA, Hankinson SE, Spiegelman D, Barbieri RL, Malspeis S, Willett WC, Hunter DJ. Reproductive History and Endometriosis Among Premenopausal Women. Obstetrics And Gynecology 2004, 104: 965-974. PMID: 15516386, DOI: 10.1097/01.aog.0000142714.54857.f8.Peer-Reviewed Original ResearchConceptsHealth Study II cohortParous womenNurses' Health Study II cohortShorter menstrual cyclesProportional hazards modelLifetime durationEarly ageShorter cycle lengthsPast infertilityPremenopausal womenNulliparous womenProspective dataMenstrual cycleReproductive factorsLiveborn childrenHazards modelLast birthEndometriosisGreater incidenceReproductive historyCycle regularityWomenAnatomical changesCalendar timeCycle lengthIncidence of Laparoscopically Confirmed Endometriosis by Demographic, Anthropometric, and Lifestyle Factors
Missmer SA, Hankinson SE, Spiegelman D, Barbieri RL, Marshall LM, Hunter DJ. Incidence of Laparoscopically Confirmed Endometriosis by Demographic, Anthropometric, and Lifestyle Factors. American Journal Of Epidemiology 2004, 160: 784-796. PMID: 15466501, DOI: 10.1093/aje/kwh275.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge DistributionAlcohol DrinkingAnthropometryBody ConstitutionBody Mass IndexDemographyEndometriosisFemaleFollow-Up StudiesHumansIncidenceInfertility, FemaleLaparoscopyLife StyleMiddle AgedMultivariate AnalysisNursesObesityPremenopauseProportional Hazards ModelsRisk FactorsSmokingStatistics, NonparametricUnited StatesWhite PeopleConceptsBody mass indexMass indexCigarette smokingLifestyle factorsNurses' Health Study II prospective cohortMultivariate Cox proportional hazards modelWaist/hip ratioCurrent body mass indexCox proportional hazards modelCurrent alcohol intakeCurrent cigarette smokingIncidence of endometriosisAge 18 yearsProportional hazards modelAfrican American womenPast infertilityLaparoscopic diagnosisProspective cohortAlcohol intakeHip ratioInfertility statusCaucasian womenIncidence rateCaffeine intakeHazards modelAssociation Between Low Birth Weight and Infant Mortality in Children Born to Human Immunodeficiency Virus 1-Infected Mothers in Tanzania
Wei R, Msamanga GI, Spiegelman D, Hertzmark E, Baylin A, Manji K, Fawzi WW. Association Between Low Birth Weight and Infant Mortality in Children Born to Human Immunodeficiency Virus 1-Infected Mothers in Tanzania. The Pediatric Infectious Disease Journal 2004, 23: 530-535. PMID: 15194834, DOI: 10.1097/01.inf.0000129691.42964.eb.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnalysis of VarianceCohort StudiesConfidence IntervalsDeveloping CountriesFemaleHIV InfectionsHIV-1HumansIncidenceInfant MortalityInfant, Low Birth WeightInfant, NewbornInfectious Disease Transmission, VerticalMalePregnancyPregnancy Complications, InfectiousPregnancy OutcomeProportional Hazards ModelsRisk FactorsSex DistributionSurvival AnalysisTanzaniaConceptsLow birth weightBirth weightHIV statusHIV transmissionInfant mortalityCox proportional hazards modelHuman immunodeficiency virus-1Child's HIV statusPediatric HIV infectionHuman immunodeficiency virusRisk of mortalityImmunodeficiency virus-1Proportional hazards modelWeeks of ageAntiretroviral treatmentHIV infectionImmunodeficiency virusNeonatal mortalityPositive infantsPregnant womenPostneonatal mortalityHazards modelMortalityInfantsVirus 1Breastfeeding and maternal HIV-1 disease progression and mortality
Sedgh G, Spiegelman D, Larsen U, Msamanga G, Fawzi WW. Breastfeeding and maternal HIV-1 disease progression and mortality. AIDS 2004, 18: 1043-1049. PMID: 15096808, DOI: 10.1097/00002030-200404300-00013.Peer-Reviewed Original ResearchConceptsHIV-1 disease progressionCD4 cell countDisease progressionCell countHigher CD4 cell countsLow CD4 cell countsCox proportional hazards modelHealth of HIVCohort study designExcessive weight lossProportional hazards modelPartial breastfeedingRelative riskHazards modelInsufficient evidenceBreastfeedingMultivariate analysisStudy designWeight lossWomenProgressionDar es SalaamHIVDeathAssociation
2002
Weight Loss and Survival in HIV-Positive Patients in the Era of Highly Active Antiretroviral Therapy
Tang AM, Forrester J, Spiegelman D, Knox TA, Tchetgen E, Gorbach SL. Weight Loss and Survival in HIV-Positive Patients in the Era of Highly Active Antiretroviral Therapy. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2002, 31: 230-236. PMID: 12394802, DOI: 10.1097/01.qai.0000026514.98625.8f.Peer-Reviewed Original ResearchConceptsActive antiretroviral therapyWeight lossAntiretroviral therapyHAART useIndependent predictorsPrevious visitHighly Active Antiretroviral TherapyHealthy Living StudyCD4 cell countHIV-positive patientsHIV-positive participantsBody mass indexStrong independent predictorFurther prognostic valueProportional hazards modelBioelectrical impedance analysisFour- to sixfold increaseImportant comorbidityMass indexPrognostic valuePotential confoundersRelative riskStudy populationLiving StudyHazards model
1997
Regression calibration method for correcting measurement-error bias in nutritional epidemiology
Spiegelman D, McDermott A, Rosner B. Regression calibration method for correcting measurement-error bias in nutritional epidemiology. American Journal Of Clinical Nutrition 1997, 65: s1179-s1186. PMID: 9094918, DOI: 10.1093/ajcn/65.4.1179s.Peer-Reviewed Original ResearchConceptsHealth StudyDietary intakeMassachusetts Women's Health StudyUltradistal radius bone densityCox proportional hazards modelRadius bone densityNurses' Health StudyWomen's Health StudyIncidence rate ratiosRate ratioProportional hazards modelOdds ratioBone densityBreast cancerHazards modelVitamin ANutritional epidemiologyLogistic regressionGold standardLinear regression modelsEpidemiologyIntakeRegression modelsValidation studyPerson error