2013
Micronutrient supplementation and T cell-mediated immune responses in patients with tuberculosis in Tanzania
KAWAI K, MEYDANI SN, URASSA W, WU D, MUGUSI FM, SAATHOFF E, BOSCH RJ, VILLAMOR E, SPIEGELMAN D, FAWZI WW. Micronutrient supplementation and T cell-mediated immune responses in patients with tuberculosis in Tanzania. Epidemiology And Infection 2013, 142: 1505-1509. PMID: 24093552, PMCID: PMC5639693, DOI: 10.1017/s0950268813002495.Peer-Reviewed Original ResearchConceptsCell-mediated immune responsesTB patientsMicronutrient supplementationMicronutrient supplementsImmune responseProliferative responseT cell-mediated immune responsesHIV-negative TB patientsHIV-positive TB patientsLymphocyte proliferative responsesLymphocyte proliferation responseHigher proliferative responsesT cell mitogensPlacebo groupPulmonary TBTB treatmentDaily doseEligible participantsNutritional interventionTuberculosis treatmentTime of initiationClinical relevanceMicronutrient groupProliferation responsePatients
2011
Predictors of change in nutritional and hemoglobin status among adults treated for tuberculosis in Tanzania
Kawai K, Villamor E, Mugusi FM, Saathoff E, Urassa W, Bosch RJ, Spiegelman D, Fawzi WW. Predictors of change in nutritional and hemoglobin status among adults treated for tuberculosis in Tanzania. The International Journal Of Tuberculosis And Lung Disease 2011, 15: 1380-1389. PMID: 22283899, PMCID: PMC3404808, DOI: 10.5588/ijtld.10.0784.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnemiaAntitubercular AgentsBiomarkersBody Mass IndexCoinfectionFemaleHealth Status IndicatorsHemoglobinsHIV InfectionsHumansLinear ModelsMaleMalnutritionMultivariate AnalysisNutritional StatusNutritional SupportProspective StudiesTanzaniaTime FactorsTreatment OutcomeTuberculosis, PulmonaryYoung AdultConceptsLow CD4 cell countsHuman immunodeficiency virusBody mass indexCD4 cell countHIV-positive patientsTB treatmentCell countPredictors of changeTB patientsHemoglobin statusHIV-negative TB patientsHIV-positive TB patientsOlder ageHIV-negative adultsHIV-negative patientsPrevious TB infectionHIV-negative participantsAdequate nutritional supportHigh viral loadProfound malnutritionTB infectionPulmonary tuberculosisNutritional recoveryNutritional supportHemoglobin levels