2022
Cardiovascular Risk Factors Mediate the Long-Term Maternal Risk Associated With Hypertensive Disorders of Pregnancy
Stuart JJ, Tanz LJ, Rimm EB, Spiegelman D, Missmer SA, Mukamal KJ, Rexrode KM, Rich-Edwards JW. Cardiovascular Risk Factors Mediate the Long-Term Maternal Risk Associated With Hypertensive Disorders of Pregnancy. Journal Of The American College Of Cardiology 2022, 79: 1901-1913. PMID: 35550687, PMCID: PMC9176211, DOI: 10.1016/j.jacc.2022.03.335.Peer-Reviewed Original ResearchConceptsCVD risk factorsRates of CVDHealth Study IIRisk of CVDBody mass indexGestational hypertensionType 2 diabetesRisk factorsChronic hypertensionHypertensive disordersMass indexNurses' Health Study IIPrepregnancy body mass indexHistory of HDPCardiovascular risk factorsOverweight/obesityProportional hazards modelIncident CVDCVD preventionNormotensive pregnanciesFirst pregnancyPotential confoundersParental historyHypertensionHazards model
1997
A prospective study of NAT2 acetylation genotype, cigarette smoking, and risk of breast cancer.
Hunter DJ, Hankinson SE, Hough H, Gertig DM, Garcia-Closas M, Spiegelman D, Manson JE, Colditz GA, Willett WC, Speizer FE, Kelsey K. A prospective study of NAT2 acetylation genotype, cigarette smoking, and risk of breast cancer. Carcinogenesis 1997, 18: 2127-2132. PMID: 9395212, DOI: 10.1093/carcin/18.11.2127.Peer-Reviewed Original ResearchConceptsRapid acetylatorsBreast cancerSlow acetylatorsCigarette smokingProspective studyFast acetylatorsNAT2 genotypeRelative riskFast NAT2 acetylatorsNAT2 acetylation genotypeMultivariate relative riskPost-menopausal womenBreast cancer riskNAT2 acetylation statusCase-control studyNon-significant elevationN-acetyltransferase 2 geneAcetylation genotypeNever smokersCurrent smokersCurrent smokingNAT2 acetylatorsFirst pregnancyIncident casesSignificant elevation