Adjunctive testing by cytology, p16/Ki‐67 dual‐stained cytology or HPV16/18 E6 oncoprotein for the management of HPV16/18 screen‐positive women
Torres‐Ibarra L, Lorincz AT, Wheeler CM, Cuzick J, Hernández‐López R, Spiegelman D, León‐Maldonado L, Rivera‐Paredez B, Méndez‐Hernández P, Lazcano‐Ponce E, Salmerón J. Adjunctive testing by cytology, p16/Ki‐67 dual‐stained cytology or HPV16/18 E6 oncoprotein for the management of HPV16/18 screen‐positive women. International Journal Of Cancer 2020, 148: 2264-2273. PMID: 33252834, DOI: 10.1002/ijc.33414.Peer-Reviewed Original ResearchConceptsHPV16/18-positive womenP16/KiLiquid-based cytologyHPV16/18-E6 oncoproteinColposcopy referralAdjunctive testingCervical intraepithelial neoplasia grade 2Dual-stained cytologyUnnecessary colposcopy referralsHigh-risk HPVCervical cancer screeningScreen-positive womenE6 oncoproteinCancer risk stratificationNormal cytologyPositive womenNonprogressive infectionRisk stratificationCervical cancerInvasive cancerCancer screeningDirect referralPositivity rateGrade 3Grade 2