2020
Erythrocyte membrane fatty acids and breast cancer risk by tumor tissue expression of immuno-inflammatory markers and fatty acid synthase: a nested case-control study
McGee EE, Kim CH, Wang M, Spiegelman D, Stover DG, Heng YJ, Collins LC, Baker GM, Farvid MS, Schedin P, Jindal S, Tamimi RM, Eliassen AH. Erythrocyte membrane fatty acids and breast cancer risk by tumor tissue expression of immuno-inflammatory markers and fatty acid synthase: a nested case-control study. Breast Cancer Research 2020, 22: 78. PMID: 32698885, PMCID: PMC7374956, DOI: 10.1186/s13058-020-01316-4.Peer-Reviewed Original ResearchConceptsBreast cancer riskImmuno-inflammatory markersErythrocyte membrane fatty acidsCase-control studyTumor tissue expressionFatty acid synthaseCancer riskTrans fatty acidsExpression subtypesOdds ratioSpecific fatty acidsLogistic regressionHealth Study IITumor tissue blocksMembrane fatty acidsFatty acidsUnconditional logistic regressionConfidence intervalsTissue expressionT cell functionPolytomous logistic regressionAcid synthaseTumor CD4Potential confoundersTumor expression
2013
Clinical malaria diagnosis in pregnancy in relation to early perinatal mother‐to‐child transmission of HIV: a prospective cohort study
Ezeamama A, Duggan C, Manji K, Spiegelman D, Hertzmark E, Bosch R, Kupka R, Okuma J, Kisenge R, Aboud S, Fawzi W. Clinical malaria diagnosis in pregnancy in relation to early perinatal mother‐to‐child transmission of HIV: a prospective cohort study. HIV Medicine 2013, 15: 276-285. PMID: 24215465, PMCID: PMC4299572, DOI: 10.1111/hiv.12111.Peer-Reviewed Original ResearchConceptsPregnant HIV-positive womenHIV-positive womenRelative riskFever symptomsHIV MTCTHIV infectionPolymerase chain reactionHIV-positive pregnant womenMultivariable logistic regression modelCent of HIVChild's HIV statusHIV MTCT riskInfants of womenPerinatal HIV infectionChild HIV infectionLaboratory-confirmed diagnosisConfidence intervalsPrenatal health careWeeks of lifeLogistic regression modelsHIV motherMaternal malariaMTCT programmeMTCT riskChild transmission
2007
Vitamins and Perinatal Outcomes Among HIV-Negative Women in Tanzania
Fawzi W, Msamanga G, Urassa W, Hertzmark E, Petraro P, Willett W, Spiegelman D. Vitamins and Perinatal Outcomes Among HIV-Negative Women in Tanzania. Obstetrical & Gynecological Survey 2007, 62: 561-563. DOI: 10.1097/01.ogx.0000279296.97522.77.Peer-Reviewed Original ResearchLow birth weightGestational age infantsHIV-negative womenMultivitamin groupBirth weightRelative riskPlacebo groupPreterm birthFetal deathGestational ageMultivitamin supplementsPregnant womenMicronutrient statusDouble-blind trialFolic acidMean birth weightSimilar baseline characteristicsWeeks gestational ageConfidence intervalsPrenatal vitamin supplementationHigher hemoglobin levelsPlacebo recipientsMaternal anemiaPerinatal outcomesBaseline characteristics
2006
Alcohol intake and ovarian cancer risk: a pooled analysis of 10 cohort studies
Genkinger JM, Hunter DJ, Spiegelman D, Anderson KE, Buring JE, Freudenheim JL, Goldbohm RA, Harnack L, Hankinson SE, Larsson SC, Leitzmann M, McCullough ML, Marshall J, Miller AB, Rodriguez C, Rohan TE, Schatzkin A, Schouten LJ, Wolk A, Zhang SM, Smith-Warner SA. Alcohol intake and ovarian cancer risk: a pooled analysis of 10 cohort studies. British Journal Of Cancer 2006, 94: 757-762. PMID: 16495916, PMCID: PMC2361197, DOI: 10.1038/sj.bjc.6603020.Peer-Reviewed Original ResearchConceptsOvarian cancer riskCohort studyCancer riskPooled analysisAlcohol intakeRelative riskStudy-specific relative risksCox proportional hazards modelDepletion of folateModerate alcohol intakeOral contraceptive useProspective cohort studyHormone replacement therapyBody mass indexConfidence intervalsLevels of estrogenSerous ovarian cancerProportional hazards modelRandom-effects modelOvarian casesMenopausal statusMass indexReplacement therapyFolate intakeOvarian cancer
2005
Influence of Body Size and Body Fat Distribution on Risk of Uterine Leiomyomata in U.S. Black Women
Wise LA, Palmer JR, Spiegelman D, Harlow BL, Stewart EA, Adams-Campbell LL, Rosenberg L. Influence of Body Size and Body Fat Distribution on Risk of Uterine Leiomyomata in U.S. Black Women. Epidemiology 2005, 16: 346-354. PMID: 15824551, PMCID: PMC1847589, DOI: 10.1097/01.ede.0000158742.11877.99.Peer-Reviewed Original ResearchConceptsBody mass indexIncidence rate ratiosBlack Women's Health StudyWomen's Health StudyParous womenUterine leiomyomataHealth StudyWeight gainMultivariate incidence rate ratiosSelf-reported uterine leiomyomataU.S. prospective cohort studiesBlack womenProspective cohort studyBody fat distributionConfidence intervalsU.S. Black womenPremenopausal womenCohort studyPrior diagnosisHip ratioMass indexHip circumferenceFat distributionHealth QuestionnaireLarge cohortHigh school dietary dairy intake and teenage acne
Adebamowo CA, Spiegelman D, Danby FW, Frazier AL, Willett WC, Holmes MD. High school dietary dairy intake and teenage acne. Journal Of The American Academy Of Dermatology 2005, 52: 207-214. PMID: 15692464, DOI: 10.1016/j.jaad.2004.08.007.Peer-Reviewed Original ResearchConceptsTeenage acnePrevalence ratiosNurses' Health Study IIDietary dairy intakeHigh school dietMultivariate prevalence ratiosHealth Study IIBody mass indexCategories of intakeLow-fat milkMass indexSchool dietDairy intakeWestern dietPresence of hormoneAcne historyPossible associationAcneEnergy intakeStudy IIIntakeBreakfast drinksConfidence intervalsTotal milkDairy foods
2004
Dairy Foods, Calcium, and Colorectal Cancer: A Pooled Analysis of 10 Cohort Studies
Cho E, Smith-Warner SA, Spiegelman D, Beeson WL, van den Brandt PA, Colditz GA, Folsom AR, Fraser GE, Freudenheim JL, Giovannucci E, Goldbohm RA, Graham S, Miller AB, Pietinen P, Potter JD, Rohan TE, Terry P, Toniolo P, Virtanen MJ, Willett WC, Wolk A, Wu K, Yaun SS, Zeleniuch-Jacquotte A, Hunter DJ. Dairy Foods, Calcium, and Colorectal Cancer: A Pooled Analysis of 10 Cohort Studies. Journal Of The National Cancer Institute 2004, 96: 1015-1022. PMID: 15240785, DOI: 10.1093/jnci/djh185.Peer-Reviewed Original ResearchMeSH KeywordsAdenomaAdultAgedAnimalsCalcium, DietaryCohort StudiesColorectal NeoplasmsDairy ProductsEatingEuropeFemaleHumansIncidenceMaleMiddle AgedMilkMultivariate AnalysisProportional Hazards ModelsProspective StudiesResearch DesignRisk AssessmentRisk FactorsSurveys and QuestionnairesUnited StatesConceptsColorectal cancerRelative riskMilk intakeCalcium intakeCohort studyPooled multivariable relative risksMultivariable relative risksFood frequency questionnaireColorectal cancer riskUsual dietary intakeConfidence intervalsDairy foodsFrequency questionnaireIncident casesDietary calciumPooled analysisLowest quintileInverse associationDietary intakeDistal colonEpidemiologic studiesCancer riskLower riskTotal calciumCancerRisk of uterine leiomyomata in relation to tobacco, alcohol and caffeine consumption in the Black Women's Health Study
Wise LA, Palmer JR, Harlow BL, Spiegelman D, Stewart EA, Adams-Campbell LL, Rosenberg L. Risk of uterine leiomyomata in relation to tobacco, alcohol and caffeine consumption in the Black Women's Health Study. Human Reproduction 2004, 19: 1746-1754. PMID: 15218005, PMCID: PMC1876785, DOI: 10.1093/humrep/deh309.Peer-Reviewed Original ResearchConceptsIncidence rate ratiosBlack Women's Health StudyWomen's Health StudyUterine leiomyomataHealth StudyCaffeine consumptionCigarette smokingMultivariate incidence rate ratiosSelf-reported uterine leiomyomataDrinks/weekConfidence intervalsUS black womenHeavy coffeePremenopausal womenIncident casesOvarian functionLeiomyomataAlcohol consumptionRate ratioHormone metabolismWomenSmokingRiskBeer consumptionBlack women
2003
Premenopausal Fat Intake and Risk of Breast Cancer
Cho E, Spiegelman D, Hunter DJ, Chen WY, Stampfer MJ, Colditz GA, Willett WC. Premenopausal Fat Intake and Risk of Breast Cancer. Journal Of The National Cancer Institute 2003, 95: 1079-1085. PMID: 12865454, DOI: 10.1093/jnci/95.14.1079.Peer-Reviewed Original ResearchConceptsBreast cancer riskDietary fat intakeHigh-fat dairy foodsHealth Study IIFat intakeBreast cancerCancer riskRelative riskPremenopausal womenIncident invasive breast cancerNurses' Health Study IIElevated breast cancer riskRed meatMultivariable relative risksAnimal fat intakeFood frequency questionnaireInvasive breast cancerConfidence intervalsCase-control studyDairy foodsPremenopausal yearsPostmenopausal womenProspective studyHighest quintileLowest quintile
2002
Dietary and Adipose Tissue Gamma-Tocopherol and Risk of Myocardial Infarction
El-Sohemy A, Baylin A, Spiegelman D, Ascherio A, Campos H. Dietary and Adipose Tissue Gamma-Tocopherol and Risk of Myocardial Infarction. Epidemiology 2002, 13: 216-223. PMID: 11880764, DOI: 10.1097/00001648-200203000-00018.Peer-Reviewed Original ResearchConceptsDietary vitamin EMyocardial infarctionGamma-tocopherolOdds ratioVitamin ENonfatal myocardial infarctionFood frequency questionnaireCoronary heart diseasePopulation-based studyFirst myocardial infarctionConfidence intervalsConditional logistic regressionAdipose tissue samplesHighest quintileSupplement usersLowest quintileHeart diseaseInverse associationDietary intakeLower riskSubstantial inverse associationMultivariate analysisLogistic regressionTissue samplesWeak associationVitamin A Supplements Ameliorate the Adverse Effect of HIV-1, Malaria, and Diarrheal Infections on Child Growth
Villamor E, Mbise R, Spiegelman D, Hertzmark E, Fataki M, Peterson KE, Ndossi G, Fawzi WW. Vitamin A Supplements Ameliorate the Adverse Effect of HIV-1, Malaria, and Diarrheal Infections on Child Growth. Pediatrics 2002, 109: e6-e6. PMID: 11773574, DOI: 10.1542/peds.109.1.e6.Peer-Reviewed Original ResearchConceptsMid-upper arm circumferenceMonths of ageVitamin A supplementsPersistent diarrheaHIV infectionRespiratory infectionsVitamin AArm circumferenceHIV statusStudy clinicTreatment armsA supplementsHigher mid-upper arm circumferenceHuman immunodeficiency virus (HIV) infectionInfectious diseasesAdverse effectsLow arm circumferenceEpisodes of infectionImmunodeficiency virus infectionDay of admissionIU vitamin APrevalence of vitaminChild growthConfidence intervalsSeverity of diarrhea
2000
Electric Blanket Use and Breast Cancer in the Nurses' Health Study
Laden F, Neas LM, Tolbert PE, Holmes MD, Hankinson SE, Spiegelman D, Speizer FE, Hunter DJ. Electric Blanket Use and Breast Cancer in the Nurses' Health Study. American Journal Of Epidemiology 2000, 152: 41-49. PMID: 10901328, DOI: 10.1093/aje/152.1.41.Peer-Reviewed Original ResearchConceptsElectric blanket useNurses' Health StudyBreast cancerHealth StudyBlanket useRelative riskEstrogen receptor-positive breast cancerReceptor-positive breast cancerBreast cancer risk factorsMultivariate relative riskInvasive breast cancerCancer risk factorsAge-adjusted analysesBreast cancer riskLong-term useElectric blanketBiennial questionnairesRisk factorsRetrospective analysisCancer riskProspective analysisCancerMultivariate modelSmall riskConfidence intervalsProspective Study of Alcohol Consumption and the Risk of Age-Related Macular Degeneration
Cho E, Hankinson SE, Willett WC, Stampfer MJ, Spiegelman D, Speizer FE, Rimm EB, Seddon JM. Prospective Study of Alcohol Consumption and the Risk of Age-Related Macular Degeneration. JAMA Ophthalmology 2000, 118: 681-688. PMID: 10815161, DOI: 10.1001/archopht.118.5.681.Peer-Reviewed Original ResearchConceptsAge-related macular degenerationRisk of AMDProspective studyMacular degenerationAlcohol consumptionRelative riskDiagnosis of AMDSemiquantitative food frequency questionnaireMale health professionalsPooled relative riskFood frequency questionnaireModerate alcohol consumptionVisual acuity lossConfidence intervalsRisk of AgeRelationship of alcoholYears of ageAlcohol intakeAcuity lossRisk factorsPooled estimatesFemale nursesHealth professionalsAdditional subjectsWomen
1999
Glutathione S -Transferase Mu and Theta Polymorphisms and Breast Cancer Susceptibility
García-Closas M, Kelsey K, Hankinson S, Spiegelman D, Springer K, Willett W, Speizer F, Hunter D. Glutathione S -Transferase Mu and Theta Polymorphisms and Breast Cancer Susceptibility. Journal Of The National Cancer Institute 1999, 91: 1960-1964. PMID: 10564681, DOI: 10.1093/jnci/91.22.1960.Peer-Reviewed Original ResearchConceptsGlutathione S-transferase mu 1Breast cancer riskBreast cancerGSTT1 null genotypeCancer riskOdds ratioNull genotypeGSTT1 genesConditional logistic regression modelsEndogenous mutagenic processesGlutathione S-transferase muConfidence intervalsGSTT1 gene deletionGSTT1 gene polymorphismsLogistic regression modelsHomozygous gene deletionBreast cancer susceptibilityTheta 1 genePremenopausal womenProspective cohortCigarette smokingIncident casesDecreased riskControl subjectsGSTT1 genotype
1998
Risk of Uterine Leiomyomata among Premenopausal Women in Relation to Body Size and Cigarette Smoking
Marshall L, Spiegelman D, Manson J, Goldman M, Barbieri R, Stampfer M, Willett W, Hunter D. Risk of Uterine Leiomyomata among Premenopausal Women in Relation to Body Size and Cigarette Smoking. Epidemiology 1998, 9: 511-517. PMID: 9730029, DOI: 10.1097/00001648-199809000-00007.Peer-Reviewed Original ResearchConceptsBody mass indexAdult body mass indexMass indexCigarette smokingUterine leiomyomataAge 18 yearsPremenopausal womenRelative riskBody mass index categoriesMultivariate relative riskConfidence intervalsIntact uterusOvarian functionNew diagnosisLeiomyomataIndex categoriesSmokingStudy questionnaireNew casesHysterectomyAge 25Weight gainWeight changeWomenRiskPhysical Activity and Breast Cancer Risk in a Cohort of Young Women
Rockhill B, Willett W, Hunter D, Manson J, Hankinson S, Spiegelman D, Colditz G. Physical Activity and Breast Cancer Risk in a Cohort of Young Women. Journal Of The National Cancer Institute 1998, 90: 1555-1160. PMID: 9701365, DOI: 10.1093/jnci/90.15.1155.Peer-Reviewed Original ResearchConceptsBreast cancer riskHealth Study IIPhysical activityRelative riskBreast cancerCancer riskNurses' Health Study IIRR of cancerBreast cancer preventionInvasive breast cancerStrenuous physical activityConfidence intervalsLate adolescenceNonoccupational physical activityYoung adult womenProspective studyNonoccupational activitiesActive womenCancer preventionReduced riskStrenuous activityAdult womenAge 18Logistic regressionYoung womenCigarette smoking, cytochrome P450 1A1 polymorphisms, and breast cancer risk in the Nurses' Health Study.
Ishibe N, Hankinson SE, Colditz GA, Spiegelman D, Willett WC, Speizer FE, Kelsey KT, Hunter DJ. Cigarette smoking, cytochrome P450 1A1 polymorphisms, and breast cancer risk in the Nurses' Health Study. Cancer Research 1998, 58: 667-71. PMID: 9485019.Peer-Reviewed Original ResearchConceptsBreast cancer riskNurses' Health StudyCigarette smokingBreast cancerCancer riskHealth StudyAryl hydrocarbon hydroxylase activityRelative riskCYP1A1 polymorphismsIncident breast cancer casesHydroxylase activityVariant CYP1A1 genotypesBreast cancer ratesBreast cancer incidenceConfidence intervalsCytochrome P450 1A1 (CYP1A1) polymorphismsCase-control studyConditional logistic regressionBreast cancer casesExon 7 polymorphismHomozygous wild typeSusceptible womenModifiable causesCancer incidenceCaucasian women
1997
Epidemiologic determinants of endometriosis: A hospital-based case-control study
Signorello L, Harlow B, Cramer D, Spiegelman D, Hill J. Epidemiologic determinants of endometriosis: A hospital-based case-control study. Annals Of Epidemiology 1997, 7: 267-274. PMID: 9177109, DOI: 10.1016/s1047-2797(97)00017-3.Peer-Reviewed Original ResearchConceptsCase-control studyControl groupHospital-based case-control studyInfertility-associated endometriosisBody mass indexConfidence intervalsPrimary control groupRisk of endometriosisEpidemiologic determinantsMenstrual characteristicsInfertile womenMass indexControl womenFertile womenInverse associationRisk factorsWomen's HospitalEndometriosisAlcohol consumptionAlternate control groupsWomenHospitalAssociationControl selectionSmoking
1992
Correction of Logistic Regression Relative Risk Estimates and Confidence Intervals for Random Within-Person Measurement Error
Rosner B, Spiegelman D, Willett WC. Correction of Logistic Regression Relative Risk Estimates and Confidence Intervals for Random Within-Person Measurement Error. American Journal Of Epidemiology 1992, 136: 1400-1413. PMID: 1488967, DOI: 10.1093/oxfordjournals.aje.a116453.Peer-Reviewed Original ResearchConceptsRelative risk estimatesRisk factorsLogistic regressionRisk estimatesCoronary risk factorsCoronary heart diseaseGold standardConfidence intervalsFramingham Heart StudyExamination 4Extreme quintilesHeart diseaseOdds ratioHeart StudyExamination 2Exposure assessmentSubstudyCovariatesMenMain studyReproducibility dataRegressionFactorsQuintileIncidence
1990
CORRECTION OF LOGISTIC REGRESSION RELATIVE RISK ESTIMATES AND CONFIDENCE INTERVALS FOR MEASUREMENT ERROR: THE CASE OF MULTIPLE COVARIATES MEASURED WITH ERROR
ROSNER B, SPIEGELMAN D, WILLETT WC. CORRECTION OF LOGISTIC REGRESSION RELATIVE RISK ESTIMATES AND CONFIDENCE INTERVALS FOR MEASUREMENT ERROR: THE CASE OF MULTIPLE COVARIATES MEASURED WITH ERROR. American Journal Of Epidemiology 1990, 132: 734-745. PMID: 2403114, DOI: 10.1093/oxfordjournals.aje.a115715.Peer-Reviewed Original ResearchConceptsAge-adjusted relative riskRelative riskRisk factorsFat intakeMultiple logistic regression modelBreast cancer riskConfidence intervalsTrue risk factorRelative risk estimatesValidation studyLogistic regression modelsMultivariate linear regression modelRegression modelsAlcohol intakeProspective studyDietary fatBreast cancerCancer riskLogistic regressionRisk estimatesIntakeRiskSeparate validation studyContinuous variablesPositive association