2005
Bidi and cigarette smoking and risk of acute myocardial infarction among males in urban India
Rastogi T, Jha P, Reddy KS, Prabhakaran D, Spiegelman D, Stampfer MJ, Willett WC, Ascherio A. Bidi and cigarette smoking and risk of acute myocardial infarction among males in urban India. Tobacco Control 2005, 14: 356. PMID: 16183987, PMCID: PMC1748103, DOI: 10.1136/tc.2005.011965.Peer-Reviewed Original Research
2004
Incidence of Laparoscopically Confirmed Endometriosis by Demographic, Anthropometric, and Lifestyle Factors
Missmer SA, Hankinson SE, Spiegelman D, Barbieri RL, Marshall LM, Hunter DJ. Incidence of Laparoscopically Confirmed Endometriosis by Demographic, Anthropometric, and Lifestyle Factors. American Journal Of Epidemiology 2004, 160: 784-796. PMID: 15466501, DOI: 10.1093/aje/kwh275.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge DistributionAlcohol DrinkingAnthropometryBody ConstitutionBody Mass IndexDemographyEndometriosisFemaleFollow-Up StudiesHumansIncidenceInfertility, FemaleLaparoscopyLife StyleMiddle AgedMultivariate AnalysisNursesObesityPremenopauseProportional Hazards ModelsRisk FactorsSmokingStatistics, NonparametricUnited StatesWhite PeopleConceptsBody mass indexMass indexCigarette smokingLifestyle factorsNurses' Health Study II prospective cohortMultivariate Cox proportional hazards modelWaist/hip ratioCurrent body mass indexCox proportional hazards modelCurrent alcohol intakeCurrent cigarette smokingIncidence of endometriosisAge 18 yearsProportional hazards modelAfrican American womenPast infertilityLaparoscopic diagnosisProspective cohortAlcohol intakeHip ratioInfertility statusCaucasian womenIncidence rateCaffeine intakeHazards modelRisk of uterine leiomyomata in relation to tobacco, alcohol and caffeine consumption in the Black Women's Health Study
Wise LA, Palmer JR, Harlow BL, Spiegelman D, Stewart EA, Adams-Campbell LL, Rosenberg L. Risk of uterine leiomyomata in relation to tobacco, alcohol and caffeine consumption in the Black Women's Health Study. Human Reproduction 2004, 19: 1746-1754. PMID: 15218005, PMCID: PMC1876785, DOI: 10.1093/humrep/deh309.Peer-Reviewed Original ResearchConceptsIncidence rate ratiosBlack Women's Health StudyWomen's Health StudyUterine leiomyomataHealth StudyCaffeine consumptionCigarette smokingMultivariate incidence rate ratiosSelf-reported uterine leiomyomataDrinks/weekConfidence intervalsUS black womenHeavy coffeePremenopausal womenIncident casesOvarian functionLeiomyomataAlcohol consumptionRate ratioHormone metabolismWomenSmokingRiskBeer consumptionBlack womenManganese Superoxide Dismutase Polymorphism, Plasma Antioxidants, Cigarette Smoking, and Risk of Breast Cancer
Tamimi RM, Hankinson SE, Spiegelman D, Colditz GA, Hunter DJ. Manganese Superoxide Dismutase Polymorphism, Plasma Antioxidants, Cigarette Smoking, and Risk of Breast Cancer. Cancer Epidemiology Biomarkers & Prevention 2004, 13: 989-996. PMID: 15184255, DOI: 10.1158/1055-9965.989.13.6.Peer-Reviewed Original ResearchConceptsBreast cancer riskHealth Study cohortBreast cancerAla alleleCancer riskCurrent smokersCigarette smokingNurses' Health Study cohortManganese superoxide dismutase polymorphismIndependent risk factorPostmenopausal hormone useCase-control studyVal/ValHormone useStudy cohortIncident casesRisk factorsPlasma antioxidantsDismutase polymorphismAlcohol consumptionVal alleleBlood collectionCancerAntioxidant levelsOxidative stressFactors influencing serum cystatin C levels other than renal function and the impact on renal function measurement
Knight EL, Verhave JC, Spiegelman D, Hillege HL, De Zeeuw D, Curhan GC, De Jong PE. Factors influencing serum cystatin C levels other than renal function and the impact on renal function measurement. Kidney International 2004, 65: 1416-1421. PMID: 15086483, DOI: 10.1111/j.1523-1755.2004.00517.x.Peer-Reviewed Original ResearchConceptsSerum cystatin C levelsCystatin C levelsSerum creatinine levelsSerum cystatin CRenal functionCreatinine levelsCreatinine clearanceCystatin CSerum creatininePartial Spearman correlationsC levelsCigarette smokingHigh serum C-reactive protein levelsHigher serum cystatin C levelsSerum C-reactive protein levelsC-reactive protein levelsSerum CRP levelsCurrent cigarette smokingRenal function measurementsSpearman correlationCross-sectional studyYears of ageCRP levelsMultivariate linear regression modelMale gender
2003
A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk.
Han J, Hankinson SE, De Vivo I, Spiegelman D, Tamimi RM, Mohrenweiser HW, Colditz GA, Hunter DJ. A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk. Cancer Research 2003, 63: 8536-41. PMID: 14679022.Peer-Reviewed Original ResearchConceptsBreast cancer riskBeta-carotene levelsCancer riskInverse associationHealth StudyXRCC1 geneNurses' Health StudyMultivariate odds ratiosCase-control studyPotential protective effectPresent study populationHaplotype-tagging single nucleotide polymorphismsXRCC1 haplotypesCigarette smokingProspective studyCaucasian womenEffect modificationOdds ratioBreast cancerProtective effectStudy populationOxidative DNA damageBreast carcinogenesisGene-environment interactionsPlasma carotenoids
2000
Prospective study of major dietary patterns and risk of coronary heart disease in men 1 , 2 , 3
Hu F, Rimm E, Stampfer M, Ascherio A, Spiegelman D, Willett W. Prospective study of major dietary patterns and risk of coronary heart disease in men 1 , 2 , 3. American Journal Of Clinical Nutrition 2000, 72: 912-921. PMID: 11010931, DOI: 10.1093/ajcn/72.4.912.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAlcohol DrinkingBody Mass IndexCohort StudiesCoronary DiseaseDietDiet RecordsDietary SupplementsExerciseFactor Analysis, StatisticalHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionProportional Hazards ModelsProspective StudiesRisk FactorsSmokingSurveys and QuestionnairesConceptsCoronary heart diseaseFood frequency questionnaireMajor dietary patternsRisk of CHDDietary patternsHeart diseaseRelative riskHigh intakePattern scoresCases of CHDHigh-fat dairy productsPrudent pattern scoresWestern pattern scoreCHD risk factorsProspective cohort studyOverall dietary patternsBody mass indexPrudent patternCohort studyCigarette smokingMass indexProspective studyHighest quintileMyocardial infarctionSubgroup analysisProportion of colon cancer risk that might be preventable in a cohort of middle-aged US men
Platz E, Willett W, Colditz G, Rimm E, Spiegelman D, Giovannucci E. Proportion of colon cancer risk that might be preventable in a cohort of middle-aged US men. Cancer Causes & Control 2000, 11: 579-588. PMID: 10977102, DOI: 10.1023/a:1008999232442.Peer-Reviewed Original ResearchConceptsColon cancer riskMiddle-aged US menRisk factorsCancer riskRisk scoreUS menPopulation attributable risk percentColon cancer risk factorsHealth Professionals FollowModifiable risk factorsAttributable risk percentCancer risk factorsColon cancer incidenceLow-risk scoresRed meat consumptionColon cancer casesLogistic regression modelsProfessionals FollowCigarette smokingColorectal neoplasiaColorectal cancerPhysical inactivityCancer incidenceCancer casesFamily history
1999
Glutathione S -Transferase Mu and Theta Polymorphisms and Breast Cancer Susceptibility
García-Closas M, Kelsey K, Hankinson S, Spiegelman D, Springer K, Willett W, Speizer F, Hunter D. Glutathione S -Transferase Mu and Theta Polymorphisms and Breast Cancer Susceptibility. Journal Of The National Cancer Institute 1999, 91: 1960-1964. PMID: 10564681, DOI: 10.1093/jnci/91.22.1960.Peer-Reviewed Original ResearchConceptsGlutathione S-transferase mu 1Breast cancer riskBreast cancerGSTT1 null genotypeCancer riskOdds ratioNull genotypeGSTT1 genesConditional logistic regression modelsEndogenous mutagenic processesGlutathione S-transferase muConfidence intervalsGSTT1 gene deletionGSTT1 gene polymorphismsLogistic regression modelsHomozygous gene deletionBreast cancer susceptibilityTheta 1 genePremenopausal womenProspective cohortCigarette smokingIncident casesDecreased riskControl subjectsGSTT1 genotypePrevalence and Predictors of Depressive Symptoms in Older Premenopausal Women: The Harvard Study of Moods and Cycles
Harlow BL, Cohen LS, Otto MW, Spiegelman D, Cramer DW. Prevalence and Predictors of Depressive Symptoms in Older Premenopausal Women: The Harvard Study of Moods and Cycles. JAMA Psychiatry 1999, 56: 418-424. PMID: 10232296, DOI: 10.1001/archpsyc.56.5.418.Peer-Reviewed Original ResearchConceptsDepressive symptomsPremenstrual symptomsCommunity-based cohort studyOlder premenopausal womenMenstrual cycle irregularityPrevalence of depressionCommunity-based studyCES-D scoresCurrent depressive symptomsSelf-administered questionnaireCohort studyPremenopausal womenNulliparous womenUpper tertileCigarette smokingMenstrual historyOvarian functionHarvard StudyCycle irregularityMajor depressionMood disordersLower riskDepression scoresDepression historySymptomsFruit and Vegetable Intake and Incidence of Bladder Cancer in a Male Prospective Cohort
Michaud D, Spiegelman D, Clinton S, Rimm E, Willett W, Giovannucci E. Fruit and Vegetable Intake and Incidence of Bladder Cancer in a Male Prospective Cohort. Journal Of The National Cancer Institute 1999, 91: 605-613. PMID: 10203279, DOI: 10.1093/jnci/91.7.605.Peer-Reviewed Original ResearchConceptsBladder cancer riskVegetable intakeCancer riskBladder cancerCruciferous vegetablesIndividual cruciferous vegetablesHealth Professionals FollowTotal fruitProspective cohort studyCruciferous vegetable consumptionFood frequency questionnaireCurrent smoking statusIncident bladder cancerPrevious epidemiologic studiesTotal fluid intakeLogistic regression analysisCarotenoid-rich vegetablesProfessionals FollowCohort studyProspective cohortSmoking statusCigarette smokingGreen leafy vegetablesInverse associationFluid intakeSmoking and risk of total and fatal prostate cancer in United States health professionals.
Giovannucci E, Rimm EB, Ascherio A, Colditz GA, Spiegelman D, Stampfer MJ, Willett WC. Smoking and risk of total and fatal prostate cancer in United States health professionals. Cancer Epidemiology Biomarkers & Prevention 1999, 8: 277-82. PMID: 10207628.Peer-Reviewed Original ResearchConceptsFatal prostate cancerProstate cancerCancer incidenceHealth professionalsCumulative smoking historyMale health professionalsSmoking-related comorbiditiesTotal prostate cancerDistant metastatic diseaseProstate cancer incidenceMetastatic prostate cancerRecent tobacco useMetastatic diseaseSmoking historyCigarette smokingLifestyle factorsExcess riskFatal casesTobacco useHigh riskScreening behaviorSmokingCigarette useCancerSmokers
1998
Risk of Uterine Leiomyomata among Premenopausal Women in Relation to Body Size and Cigarette Smoking
Marshall L, Spiegelman D, Manson J, Goldman M, Barbieri R, Stampfer M, Willett W, Hunter D. Risk of Uterine Leiomyomata among Premenopausal Women in Relation to Body Size and Cigarette Smoking. Epidemiology 1998, 9: 511-517. PMID: 9730029, DOI: 10.1097/00001648-199809000-00007.Peer-Reviewed Original ResearchConceptsBody mass indexAdult body mass indexMass indexCigarette smokingUterine leiomyomataAge 18 yearsPremenopausal womenRelative riskBody mass index categoriesMultivariate relative riskConfidence intervalsIntact uterusOvarian functionNew diagnosisLeiomyomataIndex categoriesSmokingStudy questionnaireNew casesHysterectomyAge 25Weight gainWeight changeWomenRiskCigarette smoking, cytochrome P450 1A1 polymorphisms, and breast cancer risk in the Nurses' Health Study.
Ishibe N, Hankinson SE, Colditz GA, Spiegelman D, Willett WC, Speizer FE, Kelsey KT, Hunter DJ. Cigarette smoking, cytochrome P450 1A1 polymorphisms, and breast cancer risk in the Nurses' Health Study. Cancer Research 1998, 58: 667-71. PMID: 9485019.Peer-Reviewed Original ResearchConceptsBreast cancer riskNurses' Health StudyCigarette smokingBreast cancerCancer riskHealth StudyAryl hydrocarbon hydroxylase activityRelative riskCYP1A1 polymorphismsIncident breast cancer casesHydroxylase activityVariant CYP1A1 genotypesBreast cancer ratesBreast cancer incidenceConfidence intervalsCytochrome P450 1A1 (CYP1A1) polymorphismsCase-control studyConditional logistic regressionBreast cancer casesExon 7 polymorphismHomozygous wild typeSusceptible womenModifiable causesCancer incidenceCaucasian women
1997
A prospective study of NAT2 acetylation genotype, cigarette smoking, and risk of breast cancer.
Hunter DJ, Hankinson SE, Hough H, Gertig DM, Garcia-Closas M, Spiegelman D, Manson JE, Colditz GA, Willett WC, Speizer FE, Kelsey K. A prospective study of NAT2 acetylation genotype, cigarette smoking, and risk of breast cancer. Carcinogenesis 1997, 18: 2127-2132. PMID: 9395212, DOI: 10.1093/carcin/18.11.2127.Peer-Reviewed Original ResearchConceptsRapid acetylatorsBreast cancerSlow acetylatorsCigarette smokingProspective studyFast acetylatorsNAT2 genotypeRelative riskFast NAT2 acetylatorsNAT2 acetylation genotypeMultivariate relative riskPost-menopausal womenBreast cancer riskNAT2 acetylation statusCase-control studyNon-significant elevationN-acetyltransferase 2 geneAcetylation genotypeNever smokersCurrent smokersCurrent smokingNAT2 acetylatorsFirst pregnancyIncident casesSignificant elevationGlutathione S-transferase class mu deletion polymorphism and breast cancer: results from prevalent versus incident cases.
Kelsey KT, Hankinson SE, Colditz GA, Springer K, Garcia-Closas M, Spiegelman D, Manson JE, Garland M, Stampfer MJ, Willett WC, Speizer FE, Hunter DJ. Glutathione S-transferase class mu deletion polymorphism and breast cancer: results from prevalent versus incident cases. Cancer Epidemiology Biomarkers & Prevention 1997, 6: 511-5. PMID: 9232338.Peer-Reviewed Original ResearchConceptsBreast cancerGene deletion polymorphismCase seriesDeletion polymorphismHealth StudyNull genotypeGSTM1 deletionGlutathione S-transferase class muPrevalent breast cancerIncident breast cancerNurses' Health StudyGSTM1 gene deletion polymorphismBreast cancer riskDuration of survivalAge-matched controlsGSTM1 null genotypeBreast cancer prognosisMolecular epidemiologic studiesImproved survivalCigarette smokingIncident casesOdds ratioPrevalent casesEpidemiologic studiesCancer riskA Prospective Study of Oral Contraceptives and NIDDM Among U.S. Women
Chasan-Taber L, Willett W, Stampfer M, Hunter D, Colditz G, Spiegelman D, Manson J. A Prospective Study of Oral Contraceptives and NIDDM Among U.S. Women. Diabetes Care 1997, 20: 330-335. PMID: 9051382, DOI: 10.2337/diacare.20.3.330.Peer-Reviewed Original ResearchConceptsOral contraceptivesRelative riskPast usersProspective studyModern oral contraceptivesU.S. female nursesMultivariate relative riskOral contraceptive useProspective cohort studyLarge prospective studiesLow absolute riskCoronary heart diseaseCurrent usersHistory of diagnosisDiagnosed diabetesCohort studyElevated cholesterolAlcohol intakeCigarette smokingIncident casesSymptomatic casesAbsolute riskExcess riskHeart diseaseFamily history
1996
Prospective study of oral contraceptives and hypertension among women in the United States.
Chasan-Taber L, Willett W, Manson J, Spiegelman D, Hunter D, Curhan G, Colditz G, Stampfer M. Prospective study of oral contraceptives and hypertension among women in the United States. Circulation 1996, 94: 483-9. PMID: 8759093, DOI: 10.1161/01.cir.94.3.483.Peer-Reviewed Original ResearchConceptsOral contraceptivesBody mass indexMass indexRelative riskFamily historyAge-adjusted relative riskPast usersHigh-dose pillsMultivariate relative riskOral contraceptive useProspective cohort studyRisk of hypertensionCoronary heart diseaseRisk of developmentLow-dose formulationsCurrent usersMicrograms estrogenHypertensive effectCohort studyEffect of ageBlood pressureAlcohol intakeCigarette smokingIncident casesProspective study
1982
Respiratory Morbidity Among Processing and Mill Workers: A Cross-Sectional Survey in Three Tire-Manufacturing Plants.
Sparks P, Smith T, Fine L, Treitman R, Spiegelman D. Respiratory Morbidity Among Processing and Mill Workers: A Cross-Sectional Survey in Three Tire-Manufacturing Plants. Journal Of Occupational And Environmental Medicine 1982, 24: 690. PMID: 7131111, DOI: 10.1097/00043764-198209000-00017.Peer-Reviewed Original ResearchConceptsCurrent cigarette smokersCigarette smokingRespiratory morbidityCigarette smokersDust exposureMore chronic bronchitisSmall airway obstructionLow dust exposureMean FEV1Chronic bronchitisExpiratory volumeHelium-oxygen mixtureVital capacityExposure categoriesSectional surveyTire manufacturing plantEye irritationPast exposureMill workersSmokingCurrent exposureRespirable dustMorbiditySmokersSensitive test