2004
Incidence of Laparoscopically Confirmed Endometriosis by Demographic, Anthropometric, and Lifestyle Factors
Missmer SA, Hankinson SE, Spiegelman D, Barbieri RL, Marshall LM, Hunter DJ. Incidence of Laparoscopically Confirmed Endometriosis by Demographic, Anthropometric, and Lifestyle Factors. American Journal Of Epidemiology 2004, 160: 784-796. PMID: 15466501, DOI: 10.1093/aje/kwh275.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge DistributionAlcohol DrinkingAnthropometryBody ConstitutionBody Mass IndexDemographyEndometriosisFemaleFollow-Up StudiesHumansIncidenceInfertility, FemaleLaparoscopyLife StyleMiddle AgedMultivariate AnalysisNursesObesityPremenopauseProportional Hazards ModelsRisk FactorsSmokingStatistics, NonparametricUnited StatesWhite PeopleConceptsBody mass indexMass indexCigarette smokingLifestyle factorsNurses' Health Study II prospective cohortMultivariate Cox proportional hazards modelWaist/hip ratioCurrent body mass indexCox proportional hazards modelCurrent alcohol intakeCurrent cigarette smokingIncidence of endometriosisAge 18 yearsProportional hazards modelAfrican American womenPast infertilityLaparoscopic diagnosisProspective cohortAlcohol intakeHip ratioInfertility statusCaucasian womenIncidence rateCaffeine intakeHazards model
2003
A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk.
Han J, Hankinson SE, De Vivo I, Spiegelman D, Tamimi RM, Mohrenweiser HW, Colditz GA, Hunter DJ. A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk. Cancer Research 2003, 63: 8536-41. PMID: 14679022.Peer-Reviewed Original ResearchConceptsBreast cancer riskBeta-carotene levelsCancer riskInverse associationHealth StudyXRCC1 geneNurses' Health StudyMultivariate odds ratiosCase-control studyPotential protective effectPresent study populationHaplotype-tagging single nucleotide polymorphismsXRCC1 haplotypesCigarette smokingProspective studyCaucasian womenEffect modificationOdds ratioBreast cancerProtective effectStudy populationOxidative DNA damageBreast carcinogenesisGene-environment interactionsPlasma carotenoids
2002
The androgen receptor CAG repeat polymorphism and risk of breast cancer in the Nurses' Health Study.
Haiman CA, Brown M, Hankinson SE, Spiegelman D, Colditz GA, Willett WC, Kantoff PW, Hunter DJ. The androgen receptor CAG repeat polymorphism and risk of breast cancer in the Nurses' Health Study. Cancer Research 2002, 62: 1045-9. PMID: 11861380.Peer-Reviewed Original ResearchConceptsFirst-degree family historyBreast cancer riskHealth Study cohortAndrogen receptorBreast cancerCancer riskFamily historyAR genotypeCaucasian womenHormone levelsHealth StudyNurses' Health Study cohortBreast cancer risk factorsEndogenous steroid hormone levelsNurses' Health StudyCancer risk factorsPostmenopausal Caucasian womenCase-control studyAndrogen receptor genotypeAndrogen receptor CAGAndrogen receptor allelesSteroid hormone levelsShort alleleLong alleleSignificant positive association
2001
Association of genetic polymorphisms in UGT1A1 with breast cancer and plasma hormone levels.
Guillemette C, De Vivo I, Hankinson SE, Haiman CA, Spiegelman D, Housman DE, Hunter DJ. Association of genetic polymorphisms in UGT1A1 with breast cancer and plasma hormone levels. Cancer Epidemiology Biomarkers & Prevention 2001, 10: 711-4. PMID: 11401924.Peer-Reviewed Original ResearchConceptsHealth Study cohortBreast cancer riskHormone levelsBreast cancerUGT1A1 genotypeCancer riskNurses' Health Study cohortPremenopausal breast cancer riskUDP-glucuronosyltransferasesBody mass indexCase-control studyPlasma hormone levelsUGT1A1 promoter polymorphismCommon insertion/deletion polymorphismInsertion/deletion polymorphismPostmenopausal womenHormone replacementMass indexStudy cohortEstradiol levelsEstradiol metabolismBlood drawCaucasian womenRelative riskAfrican American population
2000
Polymorphic repeat in AIB1 does not alter breast cancer risk
Haiman C, Hankinson S, Spiegelman D, Colditz G, Willett W, Speizer F, Brown M, Hunter D. Polymorphic repeat in AIB1 does not alter breast cancer risk. Breast Cancer Research 2000, 2: 378. PMID: 11056690, PMCID: PMC13920, DOI: 10.1186/bcr82.Peer-Reviewed Original ResearchConceptsBreast cancer riskHealth Study cohortCancer riskPostmenopausal breast cancer riskNurses' Health Study cohortBreast cancer incidenceCase-control studySpecific tumor characteristicsAIB1 genotypeStudy cohortTumor characteristicsCancer incidenceCaucasian womenGeneral populationAIB1Repeat polymorphismRiskAssociationCohortIncidenceGenotypesWomen
1998
Cigarette smoking, cytochrome P450 1A1 polymorphisms, and breast cancer risk in the Nurses' Health Study.
Ishibe N, Hankinson SE, Colditz GA, Spiegelman D, Willett WC, Speizer FE, Kelsey KT, Hunter DJ. Cigarette smoking, cytochrome P450 1A1 polymorphisms, and breast cancer risk in the Nurses' Health Study. Cancer Research 1998, 58: 667-71. PMID: 9485019.Peer-Reviewed Original ResearchConceptsBreast cancer riskNurses' Health StudyCigarette smokingBreast cancerCancer riskHealth StudyAryl hydrocarbon hydroxylase activityRelative riskCYP1A1 polymorphismsIncident breast cancer casesHydroxylase activityVariant CYP1A1 genotypesBreast cancer ratesBreast cancer incidenceConfidence intervalsCytochrome P450 1A1 (CYP1A1) polymorphismsCase-control studyConditional logistic regressionBreast cancer casesExon 7 polymorphismHomozygous wild typeSusceptible womenModifiable causesCancer incidenceCaucasian women
1996
Hormone Levels During Dietary Changes in Premenopausal African-American Women
Woods M, Barnett J, Spiegelman D, Trail N, Hertzmark E, Longcope C, Gorbach S. Hormone Levels During Dietary Changes in Premenopausal African-American Women. Journal Of The National Cancer Institute 1996, 88: 1369-1374. PMID: 8827014, DOI: 10.1093/jnci/88.19.1369.Peer-Reviewed Original ResearchConceptsSerum hormone levelsSex hormone-binding globulinAfrican American womenCaucasian womenHormone levelsControl dietFree E2Menstrual cycleSurvival ratePremenopausal African American womenClinical study unitSerum hormone valuesTwo-sided statistical testsEndogenous sex hormonesHormone-binding globulinTypical North American dietSame control dietSignificant lower levelsTypes of cancerNorth American dietHigh-fiber dietConcentrations of estroneSHBG levelsSerum estrogenAndrostenedione levels