2021
A Bayesian approach for estimating the partial potential impact fraction with exposure measurement error under a main study/internal validation design
Chen X, Chang J, Spiegelman D, Li F. A Bayesian approach for estimating the partial potential impact fraction with exposure measurement error under a main study/internal validation design. Statistical Methods In Medical Research 2021, 31: 404-418. PMID: 34841964, DOI: 10.1177/09622802211060514.Peer-Reviewed Original ResearchConceptsPotential impact fractionImpact fractionExposure measurement errorHealth professionalsStudy designColorectal cancer incidenceValidation study designBurden of diseaseRisk factorsCancer incidenceHealth StudyDisease casesPublic health studiesRed meatContinuous exposureExposureProfessionalsIncidenceReclassification approachValidation designDiseaseIntakeImpact of the Affordable Care Act on Colorectal Cancer Incidence and Mortality
Lee C, Kushi LH, Reed ME, Eldridge EH, Lee JK, Zhang J, Spiegelman D. Impact of the Affordable Care Act on Colorectal Cancer Incidence and Mortality. American Journal Of Preventive Medicine 2021, 62: 387-394. PMID: 34763959, PMCID: PMC8863627, DOI: 10.1016/j.amepre.2021.08.025.Peer-Reviewed Original ResearchConceptsColorectal cancer-related mortalityColorectal cancer incidenceCancer-related mortalityColorectal cancer outcomesAffordable Care ActCancer incidenceColorectal cancerCancer outcomesCare ActKaiser Permanente Northern California membersHealth plansColorectal cancer screeningInterrupted time series designRace/ethnicityCancer screeningCalifornia membersPreventive servicesPrivate health insurancePocket costsMortalityTime series designIncidenceCost sharingCancerComparison groupAnalysis of Survival Among Adults With Early-Onset Colorectal Cancer in the National Cancer Database
Cheng E, Blackburn HN, Ng K, Spiegelman D, Irwin ML, Ma X, Gross CP, Tabung FK, Giovannucci EL, Kunz PL, Llor X, Billingsley K, Meyerhardt JA, Ahuja N, Fuchs CS. Analysis of Survival Among Adults With Early-Onset Colorectal Cancer in the National Cancer Database. JAMA Network Open 2021, 4: e2112539. PMID: 34132794, PMCID: PMC8209612, DOI: 10.1001/jamanetworkopen.2021.12539.Peer-Reviewed Original ResearchConceptsEarly-onset colorectal cancerOnset colorectal cancerNational Cancer DatabaseColorectal cancerAge 51Overall survivalCancer DatabaseIncidence of CRCCox proportional hazards regressionPrimary colorectal cancerKaplan-Meier analysisProportional hazards regressionAge 50 yearsAge 25 yearsAnalysis of survivalCohort studySurvival benefitHazards regressionUnadjusted analysesCancer incidenceMAIN OUTCOMEAge 35Survival advantageLower riskStage I
2020
Estimation and inference for the population attributable risk in the presence of misclassification
Wong BHW, Lee J, Spiegelman D, Wang M. Estimation and inference for the population attributable risk in the presence of misclassification. Biostatistics 2020, 22: 805-818. PMID: 32112073, PMCID: PMC8966954, DOI: 10.1093/biostatistics/kxz067.Peer-Reviewed Original ResearchConceptsPopulation attributable riskAttributable riskPartial population attributable riskHigh red meat intakeColorectal cancer incidenceRed meat intakeAlcohol intakeRisk factorsCancer incidenceMeat intakeEpidemiologic studiesPublic health researchDisease casesStudy designValidation study designInternal validation studyHealth researchTarget populationIntakeValidation studyRiskHealth evaluation methodPresence of misclassificationIncidenceDiseaseImpact of the Affordable Care Act on Colorectal Cancer Outcomes: A Systematic Review
Xu MR, Kelly AMB, Kushi LH, Reed ME, Koh HK, Spiegelman D. Impact of the Affordable Care Act on Colorectal Cancer Outcomes: A Systematic Review. American Journal Of Preventive Medicine 2020, 58: 596-603. PMID: 32008799, PMCID: PMC7175922, DOI: 10.1016/j.amepre.2019.11.018.Peer-Reviewed Original ResearchConceptsColorectal cancer screeningAffordable Care ActCancer screeningMedicaid expansionColorectal cancerCare ActNonsignificant increaseColorectal cancer morbidityColorectal cancer outcomesColorectal cancer incidenceStage of diagnosisAffordable Care Act's impactScreening ratesCancer outcomesCancer morbidityPrecancerous lesionsCancer incidenceNonsignificant decreaseEarly diagnosisMortality rateHealth outcomesSystematic reviewHealthcare accessRelevant studiesSignificant decrease
2007
Point and interval estimates of partial population attributable risks in cohort studies: examples and software
Spiegelman D, Hertzmark E, Wand HC. Point and interval estimates of partial population attributable risks in cohort studies: examples and software. Cancer Causes & Control 2007, 18: 571-579. PMID: 17387622, DOI: 10.1007/s10552-006-0090-y.Peer-Reviewed Original ResearchConceptsCohort studyRisk factorsPartial population attributable riskNon-modifiable risk factorsSpecific exposuresPopulation attributable risk percentAttributable risk percentPopulation attributable riskBladder cancer incidenceGroups of exposureTarget populationProportion of diseaseAttributable riskDisease burdenModifiable determinantsCancer incidencePublic health researchDiseaseHealth researchExposurePopulationIncidenceProportion
2004
Fruit and Vegetable Intake and Risk of Major Chronic Disease
Hung HC, Joshipura KJ, Jiang R, Hu FB, Hunter D, Smith-Warner SA, Colditz GA, Rosner B, Spiegelman D, Willett WC. Fruit and Vegetable Intake and Risk of Major Chronic Disease. Journal Of The National Cancer Institute 2004, 96: 1577-1584. PMID: 15523086, DOI: 10.1093/jnci/djh296.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnalysis of VarianceCardiovascular DiseasesCause of DeathChronic DiseaseConfidence IntervalsConfounding Factors, EpidemiologicDiet SurveysFeeding BehaviorFemaleFollow-Up StudiesFruitHealth PersonnelHumansIncidenceMaleMiddle AgedNeoplasmsProportional Hazards ModelsProspective StudiesResearch DesignRisk AssessmentRisk FactorsSurveys and QuestionnairesUnited StatesVegetablesConceptsMajor chronic diseasesVegetable intakeCardiovascular diseaseChronic diseasesRelative riskHealth StudyVegetable consumptionGreen leafy vegetable intakeSemiquantitative food frequency questionnaireCox proportional hazards analysisOverall cancer incidenceTotal fruitNurses' Health StudyFood frequency questionnaireProportional hazards analysisStrong inverse associationProspective cohortGreen leafy vegetablesHighest quintileInverse associationCancer incidenceFood groupsHealth professionalsOverall healthDietary information
2003
Fruits, vegetables and lung cancer: A pooled analysis of cohort studies
Smith‐Warner S, Spiegelman D, Yaun S, Albanes D, Beeson WL, van den Brandt PA, Feskanich D, Folsom AR, Fraser GE, Freudenheim JL, Giovannucci E, Goldbohm RA, Graham S, Kushi LH, Miller AB, Pietinen P, Rohan TE, Speizer FE, Willett WC, Hunter DJ. Fruits, vegetables and lung cancer: A pooled analysis of cohort studies. International Journal Of Cancer 2003, 107: 1001-1011. PMID: 14601062, DOI: 10.1002/ijc.11490.Peer-Reviewed Original ResearchConceptsLung cancer riskCancer riskVegetable consumptionLung cancerRelative riskLung cancer risk factorsStudy-specific relative risksIncident lung cancer casesTotal fruitCancer risk factorsLung cancer incidenceLung cancer casesTotal vegetable consumptionRandom-effects modelCohort studyCurrent smokersSmoking habitsProspective studyQuintiles 2Pooled analysisLowest quintileResidual confoundingInverse associationRisk factorsCancer incidence
2000
Polymorphic repeat in AIB1 does not alter breast cancer risk
Haiman C, Hankinson S, Spiegelman D, Colditz G, Willett W, Speizer F, Brown M, Hunter D. Polymorphic repeat in AIB1 does not alter breast cancer risk. Breast Cancer Research 2000, 2: 378. PMID: 11056690, PMCID: PMC13920, DOI: 10.1186/bcr82.Peer-Reviewed Original ResearchConceptsBreast cancer riskHealth Study cohortCancer riskPostmenopausal breast cancer riskNurses' Health Study cohortBreast cancer incidenceCase-control studySpecific tumor characteristicsAIB1 genotypeStudy cohortTumor characteristicsCancer incidenceCaucasian womenGeneral populationAIB1Repeat polymorphismRiskAssociationCohortIncidenceGenotypesWomenProportion of colon cancer risk that might be preventable in a cohort of middle-aged US men
Platz E, Willett W, Colditz G, Rimm E, Spiegelman D, Giovannucci E. Proportion of colon cancer risk that might be preventable in a cohort of middle-aged US men. Cancer Causes & Control 2000, 11: 579-588. PMID: 10977102, DOI: 10.1023/a:1008999232442.Peer-Reviewed Original ResearchConceptsColon cancer riskMiddle-aged US menRisk factorsCancer riskRisk scoreUS menPopulation attributable risk percentColon cancer risk factorsHealth Professionals FollowModifiable risk factorsAttributable risk percentCancer risk factorsColon cancer incidenceLow-risk scoresRed meat consumptionColon cancer casesLogistic regression modelsProfessionals FollowCigarette smokingColorectal neoplasiaColorectal cancerPhysical inactivityCancer incidenceCancer casesFamily history
1999
Smoking and risk of total and fatal prostate cancer in United States health professionals.
Giovannucci E, Rimm EB, Ascherio A, Colditz GA, Spiegelman D, Stampfer MJ, Willett WC. Smoking and risk of total and fatal prostate cancer in United States health professionals. Cancer Epidemiology Biomarkers & Prevention 1999, 8: 277-82. PMID: 10207628.Peer-Reviewed Original ResearchConceptsFatal prostate cancerProstate cancerCancer incidenceHealth professionalsCumulative smoking historyMale health professionalsSmoking-related comorbiditiesTotal prostate cancerDistant metastatic diseaseProstate cancer incidenceMetastatic prostate cancerRecent tobacco useMetastatic diseaseSmoking historyCigarette smokingLifestyle factorsExcess riskFatal casesTobacco useHigh riskScreening behaviorSmokingCigarette useCancerSmokers
1998
Retrospective Analysis of Birth Weight and Prostate Cancer in the Health Professionals Follow-up Study
Platz E, Giovannucci E, Rimm E, Curhan G, Spiegelman D, Colditz G, Willett W. Retrospective Analysis of Birth Weight and Prostate Cancer in the Health Professionals Follow-up Study. American Journal Of Epidemiology 1998, 147: 1140-1144. PMID: 9645792, DOI: 10.1093/oxfordjournals.aje.a009412.Peer-Reviewed Original ResearchConceptsHealth Professionals FollowBirth weightProstate cancerProfessionals FollowProstate cancer incidenceMultivariate logistic modelModest positive associationGrade tumorsProstatic cancerCancer incidenceRelative riskRetrospective analysisOverall associationCancerPositive associationFollowAssociationLogistic modelWeightTumorsIncidenceAlcohol and Breast Cancer in Women: A Pooled Analysis of Cohort Studies
Smith-Warner SA, Spiegelman D, Yaun SS, van den Brandt PA, Folsom AR, Goldbohm RA, Graham S, Holmberg L, Howe GR, Marshall JR, Miller AB, Potter JD, Speizer FE, Willett WC, Wolk A, Hunter DJ. Alcohol and Breast Cancer in Women: A Pooled Analysis of Cohort Studies. JAMA 1998, 279: 535-540. PMID: 9480365, DOI: 10.1001/jama.279.7.535.Peer-Reviewed Original ResearchConceptsInvasive breast cancerAlcohol intakeBreast cancerAlcohol consumptionRelative riskIncident invasive breast cancerMultivariate-adjusted relative riskIncident breast cancer casesBeverage-specific alcohol consumptionMultivariate relative riskTotal alcohol intakeFood frequency questionnaireBreast cancer incidenceBreast cancer riskBreast cancer casesRandom-effects modelLong-term intakeCohort studyFrequency questionnaireProspective studyPooled analysisCancer incidenceDiet assessment instrumentsCancer casesNondietary factorsCigarette smoking, cytochrome P450 1A1 polymorphisms, and breast cancer risk in the Nurses' Health Study.
Ishibe N, Hankinson SE, Colditz GA, Spiegelman D, Willett WC, Speizer FE, Kelsey KT, Hunter DJ. Cigarette smoking, cytochrome P450 1A1 polymorphisms, and breast cancer risk in the Nurses' Health Study. Cancer Research 1998, 58: 667-71. PMID: 9485019.Peer-Reviewed Original ResearchConceptsBreast cancer riskNurses' Health StudyCigarette smokingBreast cancerCancer riskHealth StudyAryl hydrocarbon hydroxylase activityRelative riskCYP1A1 polymorphismsIncident breast cancer casesHydroxylase activityVariant CYP1A1 genotypesBreast cancer ratesBreast cancer incidenceConfidence intervalsCytochrome P450 1A1 (CYP1A1) polymorphismsCase-control studyConditional logistic regressionBreast cancer casesExon 7 polymorphismHomozygous wild typeSusceptible womenModifiable causesCancer incidenceCaucasian women
1997
Geographic Variation in Breast Cancer Incidence Rates in a Cohort of U.S. Women
Laden F, Hankinson S, Spiegelman D, Neas L, Colditz G, Hunter D, Manson J, Byrne C, Rosner B, Speizer F. Geographic Variation in Breast Cancer Incidence Rates in a Cohort of U.S. Women. Journal Of The National Cancer Institute 1997, 89: 1373-1378. PMID: 9308708, DOI: 10.1093/jnci/89.18.1373.Peer-Reviewed Original ResearchConceptsBreast cancer incidence ratesCancer incidence ratesHealth Study cohortRisk factorsIncidence ratePostmenopausal womenRelative riskHealth StudyNurses' Health Study cohortAge-adjusted breast cancer incidence ratesBreast cancer risk factorsNurses' Health StudyMultivariate-adjusted analysesAge-adjusted riskBreast cancer incidenceInvasive breast cancerBreast cancer mortalityCancer risk factorsPremenopausal womenStudy cohortIncident casesCancer mortalityExcess riskCancer incidenceBreast cancerLeisure-Time Physical Activity, Body Size, and Colon Cancer in Women
Martínez M, Giovannucci E, Spiegelman D, Willett W, Hunter D, Colditz G. Leisure-Time Physical Activity, Body Size, and Colon Cancer in Women. Journal Of The National Cancer Institute 1997, 89: 948-955. PMID: 9214674, DOI: 10.1093/jnci/89.13.948.Peer-Reviewed Original ResearchConceptsLeisure-time physical activityBody mass indexMass indexPhysical activityColon cancerRelative riskProspective studyHealth StudyHigher body mass indexHigh colon cancer riskMajor medical eventsNurses' Health StudyMedical risk factorsBody fat distributionSignificant inverse associationColon cancer incidenceColon cancer riskLean body weightHospital recordsHip ratioPhysical inactivityMetabolic equivalentsWeek scoresRisk factorsCancer incidence
1992
Dietary Fat and Fiber in Relation to Risk of Breast Cancer: An 8-Year Follow-up
Willett W, Hunter D, Stampfer M, Colditz G, Manson J, Spiegelman D, Rosner B, Hennekens C, Speizer F. Dietary Fat and Fiber in Relation to Risk of Breast Cancer: An 8-Year Follow-up. JAMA 1992, 268: 2037-2044. DOI: 10.1001/jama.1992.03490150089030.Peer-Reviewed Original ResearchTotal fat intakeBreast cancer incidenceFat intakeBreast cancerPostmenopausal womenCancer incidenceProtective effectHealth StudySelf-administered food frequency questionnaireEnergy intakePositive associationDietary fat increasesNurses' Health StudyProspective cohort studyFood frequency questionnaireTotal energy intakeMiddle-aged womenYears of ageDietary questionnaireCohort studyFrequency questionnaireIncident casesRisk factorsDietary fatCorresponding RRsDietary fat and fiber in relation to risk of breast cancer. An 8-year follow-up.
Willett WC, Hunter DJ, Stampfer MJ, Colditz G, Manson JE, Spiegelman D, Rosner B, Hennekens CH, Speizer FE. Dietary fat and fiber in relation to risk of breast cancer. An 8-year follow-up. JAMA 1992, 268: 2037-44. PMID: 1328696, DOI: 10.1001/jama.268.15.2037.Peer-Reviewed Original ResearchConceptsTotal fat intakeBreast cancer incidenceFat intakeBreast cancerPostmenopausal womenCancer incidenceProtective effectHealth StudySelf-administered food frequency questionnaireEnergy intakePositive associationDietary fat increasesNurses' Health StudyProspective cohort studyFood frequency questionnaireTotal energy intakeMiddle-aged womenYears of ageDietary questionnaireCohort studyFrequency questionnaireIncident casesRisk factorsDietary fatCorresponding RRs