2005
Plasma Carotenoids, Retinol, and Tocopherols and Risk of Breast Cancer
Tamimi RM, Hankinson SE, Campos H, Spiegelman D, Zhang S, Colditz GA, Willett WC, Hunter DJ. Plasma Carotenoids, Retinol, and Tocopherols and Risk of Breast Cancer. American Journal Of Epidemiology 2005, 161: 153-160. PMID: 15632265, DOI: 10.1093/aje/kwi030.Peer-Reviewed Original ResearchConceptsLutein/zeaxanthinBreast cancerHealth StudyPlasma carotenoidsNurses' Health StudyBreast cancer riskCase-control studyBreast cancer etiologyNodal metastasisHighest quintileInvasive cancerLowest quintileBlood drawInverse associationCancer riskAlpha-tocopherolCancerCancer etiologyGamma-tocopherolWomenRetinolQuintileRiskRole of carotenoidsAssociation
2001
Association of genetic polymorphisms in UGT1A1 with breast cancer and plasma hormone levels.
Guillemette C, De Vivo I, Hankinson SE, Haiman CA, Spiegelman D, Housman DE, Hunter DJ. Association of genetic polymorphisms in UGT1A1 with breast cancer and plasma hormone levels. Cancer Epidemiology Biomarkers & Prevention 2001, 10: 711-4. PMID: 11401924.Peer-Reviewed Original ResearchConceptsHealth Study cohortBreast cancer riskHormone levelsBreast cancerUGT1A1 genotypeCancer riskNurses' Health Study cohortPremenopausal breast cancer riskUDP-glucuronosyltransferasesBody mass indexCase-control studyPlasma hormone levelsUGT1A1 promoter polymorphismCommon insertion/deletion polymorphismInsertion/deletion polymorphismPostmenopausal womenHormone replacementMass indexStudy cohortEstradiol levelsEstradiol metabolismBlood drawCaucasian womenRelative riskAfrican American population
1999
N‐acetyl transferase 2 genotypes, meat intake and breast cancer risk
Gertig D, Hankinson S, Hough H, Spiegelman D, Colditz G, Willett W, Kelsey K, Hunter D. N‐acetyl transferase 2 genotypes, meat intake and breast cancer risk. International Journal Of Cancer 1999, 80: 13-17. PMID: 9935222, DOI: 10.1002/(sici)1097-0215(19990105)80:1<13::aid-ijc3>3.0.co;2-w.Peer-Reviewed Original ResearchConceptsBreast cancer riskRed meat intakeMeat intakeRapid acetylatorsBreast cancerSlow acetylatorsCancer riskHealth StudyLow red meat intakeHigh red meat intakeNurses' Health StudyHeterocyclic aminesLack of associationHigh-temperature cooking methodsFrequent intakeNAT2 genotypeBlood drawAcetylator genotypeBlood samplesAcetylatorsSignificant associationCancerIntakeMajor causeHuman carcinogenesis