2021
Analysis of Survival Among Adults With Early-Onset Colorectal Cancer in the National Cancer Database
Cheng E, Blackburn HN, Ng K, Spiegelman D, Irwin ML, Ma X, Gross CP, Tabung FK, Giovannucci EL, Kunz PL, Llor X, Billingsley K, Meyerhardt JA, Ahuja N, Fuchs CS. Analysis of Survival Among Adults With Early-Onset Colorectal Cancer in the National Cancer Database. JAMA Network Open 2021, 4: e2112539. PMID: 34132794, PMCID: PMC8209612, DOI: 10.1001/jamanetworkopen.2021.12539.Peer-Reviewed Original ResearchConceptsEarly-onset colorectal cancerOnset colorectal cancerNational Cancer DatabaseColorectal cancerAge 51Overall survivalCancer DatabaseIncidence of CRCCox proportional hazards regressionPrimary colorectal cancerKaplan-Meier analysisProportional hazards regressionAge 50 yearsAge 25 yearsAnalysis of survivalCohort studySurvival benefitHazards regressionUnadjusted analysesCancer incidenceMAIN OUTCOMEAge 35Survival advantageLower riskStage I
2005
Temporal Relationship Between Elevation of Epstein-Barr Virus Antibody Titers and Initial Onset of Neurological Symptoms in Multiple Sclerosis
Levin LI, Munger KL, Rubertone MV, Peck CA, Lennette ET, Spiegelman D, Ascherio A. Temporal Relationship Between Elevation of Epstein-Barr Virus Antibody Titers and Initial Onset of Neurological Symptoms in Multiple Sclerosis. JAMA 2005, 293: 2496-2500. PMID: 15914750, DOI: 10.1001/jama.293.20.2496.Peer-Reviewed Original ResearchConceptsViral capsid antigenEpstein-Barr virusMultiple sclerosisAntibody titersEBNA complexRelative riskDevelopment of MSEBV viral capsid antigenEpstein-Barr virus (EBV) antibody titersRisk of MSOnset of MSOnset of symptomsVirus antibody titersSerum antibody titersCase-control studyDefense Serum RepositoryAge 25 yearsBlood sample collectionUS military personnelTemporal relationshipCase-control setsRace/ethnicityAge-dependent relationshipEBV infectionCytomegalovirus antibodies
2000
Predictors of CD4+ lymphocyte count among HIV-Seropositive and HIV-Seronegative pregnant women in Dar Es Salaam, Tanzania
Kapiga SH, Mwakagile D, Spiegelman D, Msamanga GI, Hunter D, Fawzi WW. Predictors of CD4+ lymphocyte count among HIV-Seropositive and HIV-Seronegative pregnant women in Dar Es Salaam, Tanzania. East African Medical Journal 2000, 77: 206-11. PMID: 12858905, DOI: 10.4314/eamj.v77i4.46622.Peer-Reviewed Original ResearchConceptsHIV-seropositive womenCells/mm3Erythrocyte sedimentation rateHIV-seronegative pregnant womenWhite blood countLymphocyte countPredictors of CD4Pregnant womenHIV-seropositiveMost HIV-seropositive womenTotal white blood countHaematological indicesReduction of CD4HIV-seronegative womenT lymphocyte subsetsClinical stage 1Age 25 yearsDar es SalaamAverage age 25 yearsAsymptomatic womenBlood countSocio-demographic characteristicsCD4Blood samplesHR increase