2015
Association Between Local Pediatric Vaccination Rates and Patterns of Pneumococcal Disease in Adults
Pingali SC, Warren JL, Mead AM, Sharova N, Petit S, Weinberger DM. Association Between Local Pediatric Vaccination Rates and Patterns of Pneumococcal Disease in Adults. The Journal Of Infectious Diseases 2015, 213: 509-515. PMID: 26310307, PMCID: PMC4721904, DOI: 10.1093/infdis/jiv431.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseasePneumococcal diseaseIPD casesPopulation-based surveillance systemZip code level dataAdult IPD casesDoses of PCV7Effectiveness of PCVsPediatric vaccination ratesVaccination of childrenState immunization registryZip codesLogistic regression modelsPCV7 serotypesHigher proportionVaccination ratesImmunization registryDisease patternsDiseaseAdultsPCV7PCVSerotypesChildrenDoses
2011
Serotype replacement in disease after pneumococcal vaccination
Weinberger DM, Malley R, Lipsitch M. Serotype replacement in disease after pneumococcal vaccination. The Lancet 2011, 378: 1962-1973. PMID: 21492929, PMCID: PMC3256741, DOI: 10.1016/s0140-6736(10)62225-8.Peer-Reviewed Original ResearchConceptsNon-vaccine serotypesSerotype replacementPneumococcal diseaseHeptavalent pneumococcal conjugate vaccinePneumococcal conjugate vaccineImportant public health benefitsBenefits of vaccinationPublic health benefitsDisease surveillance systemsNVT carriagePneumococcal vaccinationSurveillance biasesConjugate vaccineVaccine serotypesCarriage prevalencePneumococcal serotypesAsymptomatic carriersCarriage dataDiseaseVaccinationHealth benefitsLow invasivenessPrevalenceSerotypesCarriage
2010
Association of Serotype with Risk of Death Due to Pneumococcal Pneumonia: A Meta-Analysis
Weinberger DM, Harboe ZB, Sanders EA, Ndiritu M, Klugman KP, Rückinger S, Dagan R, Adegbola R, Cutts F, Johnson HL, O'Brien KL, Scott JA, Lipsitch M. Association of Serotype with Risk of Death Due to Pneumococcal Pneumonia: A Meta-Analysis. Clinical Infectious Diseases 2010, 51: 692-699. PMID: 20715907, PMCID: PMC2927802, DOI: 10.1086/655828.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseaseRisk of deathCarriage prevalenceHost factorsAssociation of serotypesLower comorbidity scorePooled effect estimatesStudy-specific estimatesNasopharyngeal carriage prevalenceCase fatality ratioSerotype-specific dataHigher carriage prevalenceRandom-effects methodBacteremic pneumoniaPooled RRComorbidity scorePneumococcal pneumoniaPneumococcal diseaseMeningitis patientsDisease outcomePotential confoundingPneumoniaSerotype 14Epidemiologic measuresMeta-Analysis
2009
Pneumococcal Capsular Polysaccharide Structure Predicts Serotype Prevalence
Weinberger DM, Trzciński K, Lu YJ, Bogaert D, Brandes A, Galagan J, Anderson PW, Malley R, Lipsitch M. Pneumococcal Capsular Polysaccharide Structure Predicts Serotype Prevalence. PLOS Pathogens 2009, 5: e1000476. PMID: 19521509, PMCID: PMC2689349, DOI: 10.1371/journal.ppat.1000476.Peer-Reviewed Original ResearchConceptsSerotype replacementCarriage prevalenceNasopharyngeal carriageCapsular serotypesNon-vaccine serotypesNeutrophil-mediated killingNasopharyngeal carriage prevalenceCapsular polysaccharideVaccinated populationSerotype prevalenceEpidemiological patternsPrevalent serotypesStreptococcus pneumoniaeBacterial factorsParticular serotypePrevalenceImportant serotypesNovel biological principleSerotypesDifferent serotypesCarriageNeutrophilsBiological differencesKillingVaccination