2023
The COVID-19 pandemic as an opportunity for unravelling the causative association between respiratory viruses and pneumococcus-associated disease in young children: a prospective study
Dagan R, van der Beek B, Ben-Shimol S, Greenberg D, Shemer-Avni Y, Weinberger D, Danino D. The COVID-19 pandemic as an opportunity for unravelling the causative association between respiratory viruses and pneumococcus-associated disease in young children: a prospective study. EBioMedicine 2023, 90: 104493. PMID: 36857965, PMCID: PMC9970381, DOI: 10.1016/j.ebiom.2023.104493.Peer-Reviewed Original ResearchConceptsCommunity-acquired alveolar pneumoniaLower respiratory infectionsRespiratory syncytial virusInvasive pneumococcal diseaseHuman metapneumovirusDisease endpointsPneumococcal diseaseRespiratory virusesProspective studyNasopharyngeal pneumococcal carriagePneumococcal bacteremic pneumoniaProspective surveillance programRespiratory virus activityCommon respiratory virusesPneumococcal carriage prevalenceBurden of diseaseDifferent clinical endpointsYoung childrenCOVID-19 pandemicProportion of testsAlveolar pneumoniaBacteremic pneumoniaPneumococcal carriageRespiratory infectionsCarriage prevalence
2021
Decline in Pneumococcal Disease in Young Children During the Coronavirus Disease 2019 (COVID-19) Pandemic in Israel Associated With Suppression of Seasonal Respiratory Viruses, Despite Persistent Pneumococcal Carriage: A Prospective Cohort Study
Danino D, Ben-Shimol S, Van Der Beek BA, Givon-Lavi N, Avni YS, Greenberg D, Weinberger DM, Dagan R. Decline in Pneumococcal Disease in Young Children During the Coronavirus Disease 2019 (COVID-19) Pandemic in Israel Associated With Suppression of Seasonal Respiratory Viruses, Despite Persistent Pneumococcal Carriage: A Prospective Cohort Study. Clinical Infectious Diseases 2021, 75: e1154-e1164. PMID: 34904635, PMCID: PMC8754767, DOI: 10.1093/cid/ciab1014.Peer-Reviewed Original ResearchConceptsCommunity-acquired alveolar pneumoniaInvasive pneumococcal diseasePneumococcal carriagePneumococcal diseaseRespiratory virusesSurveillance projectCOVID-19 pandemicBacteremic pneumococcal pneumoniaNasopharyngeal pneumococcal carriageSpecific respiratory virusesSARS-CoV-2 casesFirst SARS-CoV-2 caseLower respiratory infectionsProspective cohort studyPneumococcal carriage prevalencePneumococcal serotype distributionRespiratory syncytial virusSeasonal respiratory virusesRespiratory virus detectionChest X-rayDensity of colonizationAlveolar pneumoniaPneumococcal pneumoniaCohort studyRespiratory infections
2013
Using Pneumococcal Carriage Data to Monitor Postvaccination Changes in Invasive Disease
Weinberger DM, Bruden DT, Grant LR, Lipsitch M, O'Brien KL, Pelton SI, Sanders EA, Feikin DR. Using Pneumococcal Carriage Data to Monitor Postvaccination Changes in Invasive Disease. American Journal Of Epidemiology 2013, 178: 1488-1495. PMID: 24013204, PMCID: PMC3813314, DOI: 10.1093/aje/kwt156.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseaseIPD incidenceCarriage dataProportion of IPDPCV changesNasopharyngeal carriage studyNasopharyngeal pneumococcal carriagePre-PCV7 periodYears of agePCV7 introductionPneumococcal diseaseCarriage prevalenceNonvaccine serotypesPneumococcal carriageVaccine impactInvasive diseaseCarriage studiesHigh-quality surveillance systemsAmerican Indian populationsSerotype dataIncidenceIndian populationMixed effects modelsSerotypesVaccine