2023
2618. Four Respiratory Viruses are Involved in the Majority of Community-Acquired Alveolar Pneumonia (CAAP) Episodes in Children < 5 Years
Dagan R, van der Beek B, Greenberg D, Ben-Shimol S, Keren-Naos A, Weinberger D, Danino D. 2618. Four Respiratory Viruses are Involved in the Majority of Community-Acquired Alveolar Pneumonia (CAAP) Episodes in Children < 5 Years. Open Forum Infectious Diseases 2023, 10: ofad500.2231. PMCID: PMC10679033, DOI: 10.1093/ofid/ofad500.2231.Peer-Reviewed Original ResearchAlveolar pneumoniaRespiratory virusesBacterial-viral coinfectionsOnly medical centerProspective active surveillanceYoung childrenGrant/research supportParainfluenza virusActive surveillanceMedical CenterNasal samplesHospitalizationPositive specimensEpidemiological activityViral detectionStudy periodViral activityMonthly incidenceMultiple studiesVirusPneumoniaChildrenEpisodesMain virusesRSVThe COVID-19 pandemic as an opportunity for unravelling the causative association between respiratory viruses and pneumococcus-associated disease in young children: a prospective study
Dagan R, van der Beek B, Ben-Shimol S, Greenberg D, Shemer-Avni Y, Weinberger D, Danino D. The COVID-19 pandemic as an opportunity for unravelling the causative association between respiratory viruses and pneumococcus-associated disease in young children: a prospective study. EBioMedicine 2023, 90: 104493. PMID: 36857965, PMCID: PMC9970381, DOI: 10.1016/j.ebiom.2023.104493.Peer-Reviewed Original ResearchConceptsCommunity-acquired alveolar pneumoniaLower respiratory infectionsRespiratory syncytial virusInvasive pneumococcal diseaseHuman metapneumovirusDisease endpointsPneumococcal diseaseRespiratory virusesProspective studyNasopharyngeal pneumococcal carriagePneumococcal bacteremic pneumoniaProspective surveillance programRespiratory virus activityCommon respiratory virusesPneumococcal carriage prevalenceBurden of diseaseDifferent clinical endpointsYoung childrenCOVID-19 pandemicProportion of testsAlveolar pneumoniaBacteremic pneumoniaPneumococcal carriageRespiratory infectionsCarriage prevalence
2021
Decline in Pneumococcal Disease in Young Children During the Coronavirus Disease 2019 (COVID-19) Pandemic in Israel Associated With Suppression of Seasonal Respiratory Viruses, Despite Persistent Pneumococcal Carriage: A Prospective Cohort Study
Danino D, Ben-Shimol S, Van Der Beek BA, Givon-Lavi N, Avni YS, Greenberg D, Weinberger DM, Dagan R. Decline in Pneumococcal Disease in Young Children During the Coronavirus Disease 2019 (COVID-19) Pandemic in Israel Associated With Suppression of Seasonal Respiratory Viruses, Despite Persistent Pneumococcal Carriage: A Prospective Cohort Study. Clinical Infectious Diseases 2021, 75: e1154-e1164. PMID: 34904635, PMCID: PMC8754767, DOI: 10.1093/cid/ciab1014.Peer-Reviewed Original ResearchConceptsCommunity-acquired alveolar pneumoniaInvasive pneumococcal diseasePneumococcal carriagePneumococcal diseaseRespiratory virusesSurveillance projectCOVID-19 pandemicBacteremic pneumococcal pneumoniaNasopharyngeal pneumococcal carriageSpecific respiratory virusesSARS-CoV-2 casesFirst SARS-CoV-2 caseLower respiratory infectionsProspective cohort studyPneumococcal carriage prevalencePneumococcal serotype distributionRespiratory syncytial virusSeasonal respiratory virusesRespiratory virus detectionChest X-rayDensity of colonizationAlveolar pneumoniaPneumococcal pneumoniaCohort studyRespiratory infections