2015
Distributions of heavy metals in maternal and cord blood and the association with infant birth weight in China.
Hu X, Zheng T, Cheng Y, Holford T, Lin S, Leaderer B, Qiu J, Bassig BA, Shi K, Zhang Y, Niu J, Zhu Y, Li Y, Guo H, Chen Q, Zhang J, Xu S, Jin Y. Distributions of heavy metals in maternal and cord blood and the association with infant birth weight in China. The Journal Of Reproductive Medicine 2015, 60: 21-9. PMID: 25745747, PMCID: PMC4961246.Peer-Reviewed Original ResearchConceptsInfant birth weightCord blood samplesBirth weightCord bloodBlood samplesChinese pregnant womenMother-infant pairsBirth outcomesSerum levelsPregnant womenPrenatal exposureSerum concentrationsChinese infantsMultiple linear regression analysisLarger sample sizeLinear regression analysisSignificant associationChinese womenPilot studyBloodRegression analysisNewbornsAssociationWomenHigh concentrations
2012
An environmental epigenetic study of ADRB2 5′‐UTR methylation and childhood asthma severity
Fu A, Leaderer BP, Gent JF, Leaderer D, Zhu Y. An environmental epigenetic study of ADRB2 5′‐UTR methylation and childhood asthma severity. Clinical & Experimental Allergy 2012, 42: 1575-1581. PMID: 22862293, PMCID: PMC3673701, DOI: 10.1111/j.1365-2222.2012.04055.x.Peer-Reviewed Original ResearchConceptsChildhood asthma severityAsthma severitySevere asthmaSignificant associationSevere childhood asthmaBeta-agonist treatmentBeta-2 adrenergic receptorsImportant environmental exposuresAsthma exacerbationsAsthma medicationsMild asthmaChildhood asthmaSurrogate biomarkerMethylation-specific PCRPotential joint effectsClinical relevanceAdrenergic receptorsAsthmaADRB2SeverityEnvironmental exposuresIndoor exposureChildrenAssociationBlood
2005
Indoor nitrous acid and respiratory symptoms and lung function in adults
Jarvis D, Leaderer B, Chinn S, Burney P. Indoor nitrous acid and respiratory symptoms and lung function in adults. Thorax 2005, 60: 474. PMID: 15923247, PMCID: PMC1747426, DOI: 10.1136/thx.2004.032177.Peer-Reviewed Original ResearchConceptsLung functionRespiratory symptomsHealth effectsIndoor NO2Lower lung functionMore respiratory symptomsNon-significant increaseFEV1/Expiratory volumeVital capacityRelevant confoundersSecond percentageEpidemiological studiesSignificant associationSymptomsHome levelAssociationAdultsOutdoor levelsHigh levelsLevelsFailureConfoundersMonths