2016
Indoor microbial communities: Influence on asthma severity in atopic and nonatopic children
Dannemiller KC, Gent JF, Leaderer BP, Peccia J. Indoor microbial communities: Influence on asthma severity in atopic and nonatopic children. Journal Of Allergy And Clinical Immunology 2016, 138: 76-83.e1. PMID: 26851966, PMCID: PMC5357886, DOI: 10.1016/j.jaci.2015.11.027.Peer-Reviewed Original ResearchConceptsAsthma severityAtopic statusAtopic childrenNonatopic childrenLogistic regressionMicrobial exposureChildhood asthma severityCohort of childrenAsthmatic childrenAllergenic fungal speciesTotal fungal concentrationsSeverityHouse dustCryptococcus speciesExposure metricsChildrenT-testCohortQuantitative PCRFungal concentrationsAssociationExposureNext-generation DNA sequencingStatusRegression
2012
An environmental epigenetic study of ADRB2 5′‐UTR methylation and childhood asthma severity
Fu A, Leaderer BP, Gent JF, Leaderer D, Zhu Y. An environmental epigenetic study of ADRB2 5′‐UTR methylation and childhood asthma severity. Clinical & Experimental Allergy 2012, 42: 1575-1581. PMID: 22862293, PMCID: PMC3673701, DOI: 10.1111/j.1365-2222.2012.04055.x.Peer-Reviewed Original ResearchConceptsChildhood asthma severityAsthma severitySevere asthmaSignificant associationSevere childhood asthmaBeta-agonist treatmentBeta-2 adrenergic receptorsImportant environmental exposuresAsthma exacerbationsAsthma medicationsMild asthmaChildhood asthmaSurrogate biomarkerMethylation-specific PCRPotential joint effectsClinical relevanceAdrenergic receptorsAsthmaADRB2SeverityEnvironmental exposuresIndoor exposureChildrenAssociationBloodAssociation Of Atopic Status And Exposure To Household Fungi And Dust Allergens To Childhood Asthma Severity
Gent J, Kezik J, Hill M, Tsai E, Li D, Leaderer B. Association Of Atopic Status And Exposure To Household Fungi And Dust Allergens To Childhood Asthma Severity. 2012, a2223-a2223. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2223.Peer-Reviewed Original Research
1985
Respiratory symptoms associated with sulfur dioxide exposure
Witek T, Schachter E, Beck G, Cain W, Colice G, Leaderer B. Respiratory symptoms associated with sulfur dioxide exposure. International Archives Of Occupational And Environmental Health 1985, 55: 179-183. PMID: 3988360, DOI: 10.1007/bf00378381.Peer-Reviewed Original ResearchConceptsAsthmatic subjectsHealthy subjectsDose-dependent bronchoconstrictionLower airway symptomsUpper airway complaintsSeverity of complaintsLower respiratory complaintsSulfur dioxide exposureAirway complaintsAirway symptomsChest tightnessRespiratory symptomsRespiratory complaintsClinical significanceSymptomsComplaintsAsthmaticsSubjective responsesSensitive individualsSubjectsExposureLevels of SO2DyspneaBronchoconstrictionSeverity