2020
Worksite intervention study to prevent diabetes in Nepal: a randomised trial protocol
Pyakurel P, Shrestha A, Karmacharya BM, Budhathoki SS, Chaudhari RK, Tamrakar D, Shrestha A, Karmacharya RM, Shrestha A, Sharma S, Sharma SK, Spiegelman D. Worksite intervention study to prevent diabetes in Nepal: a randomised trial protocol. Open Heart 2020, 7: e001236. PMID: 32847993, PMCID: PMC7451278, DOI: 10.1136/openhrt-2019-001236.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersBlood GlucoseDiabetes MellitusGlycated HemoglobinHealth BehaviorHealth Knowledge, Attitudes, PracticeHealthy LifestyleHumansMaleMiddle AgedMulticenter Studies as TopicNepalOccupational Health ServicesPatient Education as TopicPrediabetic StatePrimary PreventionRandomized Controlled Trials as TopicRisk Reduction BehaviorTime FactorsTreatment OutcomeConceptsBehavioral interventionsControl periodDiabetes risk reductionMonth control periodNepal Health Research CouncilBehavioral intervention groupWorksite intervention studiesT-testHealth Research CouncilInstitutional review boardTwo-sample t-testBlood sugarTrial protocolIntervention groupEthical approvalControl groupIntervention studiesType 2More monthsReview boardInterventionDiabetesParticipant changesPublic healthRisk reductionNUrse-led COntinuum of care for people with Diabetes and prediabetes (NUCOD) in Nepal: study protocol for a cluster randomized controlled trial
Xu D, Dev R, Shrestha A, Zhang L, Shrestha A, Shakya P, Hughes JP, Shakya PR, Li J, Liao J, Karmacharya BM. NUrse-led COntinuum of care for people with Diabetes and prediabetes (NUCOD) in Nepal: study protocol for a cluster randomized controlled trial. Trials 2020, 21: 442. PMID: 32471476, PMCID: PMC7257188, DOI: 10.1186/s13063-020-04372-5.Peer-Reviewed Original ResearchMeSH KeywordsCluster AnalysisContinuity of Patient CareCost-Benefit AnalysisDiabetes Mellitus, Type 2Glycated HemoglobinHumansMulticenter Studies as TopicNepalNurse's RoleNursing ServicesOutcome and Process Assessment, Health CarePatient Education as TopicPrediabetic StateProgram EvaluationRandomized Controlled Trials as TopicRisk FactorsRisk Reduction BehaviorConceptsUsual treatment groupPrimary care centersType 2 diabetesManagement of diabetesRE-AIM frameworkImplementation outcomesContinuum of careUnit of randomizationLow-income settingsPrediabetes individualsTreat basisDiabetes nursesDiabetes preventionPrimary outcomeClinical outcomesHemoglobin levelsDiabetes individualsDiabetes programParallel groupStudy protocolCare centerIntervention groupTwo-armCare modelCare approachAn integrated intervention for chronic care management in rural Nepal: protocol of a type 2 hybrid effectiveness-implementation study
Schwarz D, Dhungana S, Kumar A, Acharya B, Agrawal P, Aryal A, Baum A, Choudhury N, Citrin D, Dangal B, Dhimal M, Gauchan B, Gupta T, Halliday S, Karmacharya B, Kishore S, Koirala B, Kshatriya U, Levine E, Maru S, Rimal P, Sapkota S, Schwarz R, Shrestha A, Thapa A, Maru D. An integrated intervention for chronic care management in rural Nepal: protocol of a type 2 hybrid effectiveness-implementation study. Trials 2020, 21: 119. PMID: 31996250, PMCID: PMC6990567, DOI: 10.1186/s13063-020-4063-3.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol DrinkingAllied Health PersonnelChronic DiseaseCommunity Health WorkersDecision Support Systems, ClinicalDisease ManagementHumansImplementation ScienceMedication AdherenceMotivational InterviewingNepalNoncommunicable DiseasesRisk Reduction BehaviorRural PopulationTobacco Use CessationConceptsHybrid effectiveness-implementation studyEffectiveness-implementation studyChronic care managementMid-level practitionersCare management interventionCommunity health workersCare managementMiddle-income countriesHealth workersChronic care management programWorld Health Organization PackageRisk factor optimizationClinical decision support toolEvidence-based careCare management programPrimary care systemRural NepalTobacco consumption levelsEvidence-based componentsMultiple comorbiditiesSecondary outcomesUniversal health coveragePrimary outcomeMedication adherencePre-post design
2019
Nepal Pioneer Worksite Intervention Study to lower cardio-metabolic risk factors: design and protocol
Shrestha A, Tamrakar D, Karmacharya BM, Shrestha A, Shrestha R, Bhatta RD, Pyakurel P, Khudyakov P, Malik V, Mattei J, Spiegelman D. Nepal Pioneer Worksite Intervention Study to lower cardio-metabolic risk factors: design and protocol. BMC Cardiovascular Disorders 2019, 19: 48. PMID: 30819098, PMCID: PMC6393979, DOI: 10.1186/s12872-019-1025-3.Peer-Reviewed Original ResearchMeSH KeywordsCardiovascular DiseasesDiet, HealthyExerciseFemaleFood ServicesHealth Knowledge, Attitudes, PracticeHumansMaleMetabolic SyndromeNepalOccupational Health ServicesPatient Education as TopicProtective FactorsRandomized Controlled Trials as TopicRisk FactorsRisk Reduction BehaviorTime FactorsTreatment OutcomeConceptsCardio-metabolic riskWorksite intervention studiesIntervention studiesBlood sugarCardiovascular disease prevention effortsPrevention programsCardio-metabolic risk factorsBehavioral interventionsCardio-metabolic outcomesTrial registrationThe trialElevated blood pressureDiabetes Prevention ProgramCardiovascular disease burdenProportion of participantsDisease prevention effortsHealthy food choicesChi-square testEnvironmental-level changesIndividual behavioral interventionsDhulikhel HospitalBlood pressureDietary interventionPre-post designLifestyle factorsDisease burden
2018
Dietary interventions to prevent and manage diabetes in worksite settings: a meta-analysis
Shrestha A, Karmacharya BM, Khudyakov P, Weber MB, Spiegelman D. Dietary interventions to prevent and manage diabetes in worksite settings: a meta-analysis. Journal Of Occupational Health 2018, 60: 31-45. PMID: 29187673, PMCID: PMC5799099, DOI: 10.1539/joh.17-0121-ra.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood GlucoseDiabetes Mellitus, Type 2Diet TherapyFemaleGlycated HemoglobinHumansMaleOccupational DiseasesProgram EvaluationRisk Reduction BehaviorWorkplaceConceptsRandom-effects modelDietary interventionWorksite settingWorkplace dietary interventionsBlood sugar levelsAllied Health LiteraturePooled effect sizeFemale participantsMultivariate meta-regression modelWeb of ScienceIndividual-level interventionsLifestyle interventionGlucose toleranceMeta-regression modelsBorderline significanceMore effective interventionsCumulative IndexReference listsStudy heterogeneityHealth LiteratureEffective interventionsSugar levelsSearch termsInterventionEffect size
2017
Awareness, Prevalence, Treatment, and Control of Hypertension in Western Nepal
Neupane D, Shrestha A, Mishra SR, Bloch J, Christensen B, McLachlan CS, Karki A, Kallestrup P. Awareness, Prevalence, Treatment, and Control of Hypertension in Western Nepal. American Journal Of Hypertension 2017, 30: 907-913. PMID: 28531244, DOI: 10.1093/ajh/hpx074.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntihypertensive AgentsAwarenessBlood PressureChi-Square DistributionCross-Sectional StudiesFemaleHealth Care SurveysHealth Knowledge, Attitudes, PracticeHumansHypertensionLife StyleLogistic ModelsMaleMiddle AgedMultivariate AnalysisNepalOdds RatioPrevalenceRisk FactorsRisk Reduction BehaviorSuburban HealthTreatment OutcomeConceptsControl of hypertensionBlood pressureRisk factorsHigher body mass indexBP control targetsPrevalence of hypertensionModifiable risk factorsSex-adjusted prevalenceDiastolic blood pressureLow physical activitySystolic blood pressureBody mass indexHarmful alcohol intakeHarmful alcohol drinkersCross-sectional surveyLow-income settingsSemi-urban settingHypertension burdenHypertensive medicationsPreexisting hypertensionHypertensive participantsAntihypertensive medicinesRenal diseaseMass indexAlcohol drinkers