Articles

The role of cardiovascular disease as a mediator in mitigating the impact of ambient PM2.5 on dementia risk

Lin C, Zhang Y, DeWan A, Forastiere L, Chen K. The role of cardiovascular disease as a mediator in mitigating the impact of ambient PM2.5 on dementia risk. Environmental Epidemiology 2025, 9: e436. PMID: 41200148, PMCID: PMC12588692, DOI: 10.1097/ee9.0000000000000436.

Peer-Reviewed Original Research

Genome-wide association study of childhood B-cell acute lymphoblastic leukemia reveals novel African ancestry-specific susceptibility loci

Im C, Raduski A, Mills L, Bhattarai K, Mobley R, Barnett K, Lu Z, Liao K, Anderson N, Johnson R, Langer E, Hooten A, Seif A, Bernt K, Tsang M, Mamou B, Gil-de-Gómez L, Wolfson J, Friedman D, Shukla N, Klesse L, Marcotte E, Ji L, Dang A, Luo M, Zhong Y, Langie J, Chiang C, de Smith A, Wiemels J, DeWan A, Ma X, Metayer C, Wang Z, Nelson H, Pankratz N, Yang T, Basu S, Turcotte L, Yang J, Savic D, Scheurer M, Spector L. Genome-wide association study of childhood B-cell acute lymphoblastic leukemia reveals novel African ancestry-specific susceptibility loci. Nature Communications 2025, 16: 8974. PMID: 41125582, PMCID: PMC12546916, DOI: 10.1038/s41467-025-64337-7.

Peer-Reviewed Original Research

MeSH Keywords and Concepts

Evaluation of disparities in the incidence, presentation, and treatment of pediatric differentiated thyroid cancer in the United States (2000–2022)

Ning X, Wang R, Ogilvie J, Dinauer C, Ma X, Deziel N. Evaluation of disparities in the incidence, presentation, and treatment of pediatric differentiated thyroid cancer in the United States (2000–2022). PLOS ONE 2025, 20: e0333401. PMID: 41100458, PMCID: PMC12530529, DOI: 10.1371/journal.pone.0333401.

Peer-Reviewed Original Research

8287348 Evaluation and update of an algorithm for quantitatively estimating non-occupational pesticide exposure for spouses in the agricultural health study

Friesen M, Xie S, Deziel N, Josse P, Madrigal J, Parks C, Sandler D, Andreotti G, Ward M, Hofmann J, Beane Freeman L. 8287348 Evaluation and update of an algorithm for quantitatively estimating non-occupational pesticide exposure for spouses in the agricultural health study. 2025, a12.1-a12. DOI: 10.1136/oemed-2025-epicohabstracts.29.

Peer-Reviewed Original Research

Concepts

Incorporating additive genetic effects and linkage disequilibrium information to discover gene-environment interactions using BV-LDER-GE

Dong Z, Jiang W, Shen J, Li H, Xie Y, DeWan A, Zhao H. Incorporating additive genetic effects and linkage disequilibrium information to discover gene-environment interactions using BV-LDER-GE. Genome Biology 2025, 26: 332. PMID: 41044620, PMCID: PMC12492645, DOI: 10.1186/s13059-025-03815-z.

Peer-Reviewed Original Research

A Hypothetical PM2.5 Intervention for the Risk of Hospitalization for Cardiovascular Diseases

Lin C, Chu L, Liu R, Gasparrini A, DeWan A, Forastiere L, Chen K. A Hypothetical PM2.5 Intervention for the Risk of Hospitalization for Cardiovascular Diseases. JAMA Network Open 2025, 8: e2539862. PMID: 41148138, PMCID: PMC12569718, DOI: 10.1001/jamanetworkopen.2025.39862.

Peer-Reviewed Original Research

A systematic review of residential proximity to upstream oil and gas development and childhood, adolescent and young adult cancer risk

Stewart E, Johnson N, Clark C, Metayer C, Deziel N. A systematic review of residential proximity to upstream oil and gas development and childhood, adolescent and young adult cancer risk. Current Problems In Pediatric And Adolescent Health Care 2025, 55: 101838. PMID: 40975664, DOI: 10.1016/j.cppeds.2025.101838.

Peer-Reviewed Original Research

Paternal and maternal exposures to per- and polyfluoroalkyl substances (PFAS) and birth outcomes: a multi-country cohort study

Guo P, Luo J, Zhang J, Bonde J, Struciński P, Ohniev V, Arah O, Deziel N, Warren J, Toft G, Liew Z. Paternal and maternal exposures to per- and polyfluoroalkyl substances (PFAS) and birth outcomes: a multi-country cohort study. Environmental Health 2025, 24: 48. PMID: 40652244, PMCID: PMC12255010, DOI: 10.1186/s12940-025-01199-y.

Peer-Reviewed Original Research

Perinatal Exposures to Ambient Fine Particulate Matter and Outdoor Artificial Light at Night and Risk of Pediatric Papillary Thyroid Cancer

Deziel N, Wang R, Warren J, Dinauer C, Ogilvie J, Clark C, Zhong C, Wiemels J, Morimoto L, Metayer C, Ma X. Perinatal Exposures to Ambient Fine Particulate Matter and Outdoor Artificial Light at Night and Risk of Pediatric Papillary Thyroid Cancer. Environmental Health Perspectives 2025, 133: 057026. PMID: 40209106, PMCID: PMC12121722, DOI: 10.1289/ehp14849.

Peer-Reviewed Original Research

MeSH Keywords and Concepts

Leveraging Alzheimer’s Disease Omics to Identify Pleiotropic Genes Contributing to Neurodegeneration in Primary Open-Angle Glaucoma

Tolosa-Tort P, DeWan A. Leveraging Alzheimer’s Disease Omics to Identify Pleiotropic Genes Contributing to Neurodegeneration in Primary Open-Angle Glaucoma. Molecular Neurobiology 2025, 62: 12488-12497. PMID: 40411683, DOI: 10.1007/s12035-025-05074-2.

Peer-Reviewed Original Research

A Narrative Review of Spatial–Temporal Data Sources for Estimating Population-Level Exposures to Oil and Gas Development in the United States

Campbell E, Koenig M, Mooney F, Clark C, González D, Deziel N, Casey J, Buonocore J, Willis M. A Narrative Review of Spatial–Temporal Data Sources for Estimating Population-Level Exposures to Oil and Gas Development in the United States. Current Environmental Health Reports 2025, 12: 21. PMID: 40263220, PMCID: PMC12308367, DOI: 10.1007/s40572-025-00485-8.

Peer-Reviewed Original Research

MeSH Keywords and Concepts

Estimating the Effects of Hypothetical Ambient PM2.5 Interventions on the Risk of Dementia Using the Parametric g-Formula in the UK Biobank Cohort

Lin C, Liu R, Sutton C, DeWan A, Forastiere L, Chen K. Estimating the Effects of Hypothetical Ambient PM2.5 Interventions on the Risk of Dementia Using the Parametric g-Formula in the UK Biobank Cohort. Environmental Health Perspectives 2025, 133: 047007. PMID: 40062909, PMCID: PMC12010936, DOI: 10.1289/ehp14723.

Peer-Reviewed Original Research

Paternal and Maternal Exposures to Per- and Polyfluoroalkyl Substances and Child Behavioral Difficulties: A Parental Comparison Study

Guo P, Luo J, Zhang J, Bonde J, Struciński P, Ohniev V, Arah O, Deziel N, Warren J, Toft G, Liew Z. Paternal and Maternal Exposures to Per- and Polyfluoroalkyl Substances and Child Behavioral Difficulties: A Parental Comparison Study. Environmental Science And Technology 2025, 59: 5973-5982. PMID: 40104843, DOI: 10.1021/acs.est.4c13040.

Peer-Reviewed Original Research

Perinatal exposure to ambient fine particle air pollution and risk of childhood ewing sarcoma in a population-based case-control study in California (1988–2015)

Clark C, Wang R, Wiemels J, Metayer C, Deziel N, Ma X. Perinatal exposure to ambient fine particle air pollution and risk of childhood ewing sarcoma in a population-based case-control study in California (1988–2015). Environmental Health 2025, 24: 6. PMID: 40055781, PMCID: PMC11887085, DOI: 10.1186/s12940-025-01159-6.

Peer-Reviewed Original Research

Mendelian non-syndromic and syndromic hearing loss genes contribute to presbycusis

Cornejo-Sanchez D, Bharadwaj T, Dong R, Wang G, Schrauwen I, DeWan A, Leal S. Mendelian non-syndromic and syndromic hearing loss genes contribute to presbycusis. European Journal Of Human Genetics 2025, 33: 758-767. PMID: 40055553, PMCID: PMC12185688, DOI: 10.1038/s41431-025-01789-x.

Peer-Reviewed Original Research

The case-only design is a powerful approach to detect interactions but should be used with caution

Dong R, Wang G, DeWan A, Leal S. The case-only design is a powerful approach to detect interactions but should be used with caution. BMC Genomics 2025, 26: 222. PMID: 40050722, PMCID: PMC11884093, DOI: 10.1186/s12864-025-11318-1.

Peer-Reviewed Original Research

Demographic inequities and cumulative environmental burdens within communities near superfund sites on Long Island, New York

Mooney F, Kelly J, Warren J, Deziel N. Demographic inequities and cumulative environmental burdens within communities near superfund sites on Long Island, New York. Health & Place 2025, 91: 103409. PMID: 39799904, PMCID: PMC11792615, DOI: 10.1016/j.healthplace.2024.103409.

Peer-Reviewed Original Research

Acetaminophen Use in Pregnancy: A Comparison of Self-Reported Intake with Maternal and Newborn Biomarker Measures

Guo P, Johnson C, Yan H, Xiao J, Dennis C, Pierce K, DeWan A, Liew Z. Acetaminophen Use in Pregnancy: A Comparison of Self-Reported Intake with Maternal and Newborn Biomarker Measures. Clinical Epidemiology 2025, 17: 1-6. PMID: 39781206, PMCID: PMC11705965, DOI: 10.2147/clep.s484953.

Peer-Reviewed Original Research

Concepts

Metrics of Urbanicity and Rurality in US-Based Epidemiologic Studies of Ambient Temperature and Health: A Scoping Review

Johnson N, Del Favero-Campbell A, Nori-Sarma A, Amezcua-Smith A, Lewis B, Chen C, Lin C, Foo D, Byun G, Choi H, Kim H, Berman J, Son J, Warren J, Chen K, Burrows K, Fong K, Goldsmith L, Meadows M, Smith M, Stewart R, Heo S, Lin S, Ning X, Choi Y, Bell M, Deziel N. Metrics of Urbanicity and Rurality in US-Based Epidemiologic Studies of Ambient Temperature and Health: A Scoping Review. Current Environmental Health Reports 2025, 12: 30. PMID: 40830732, PMCID: PMC12364962, DOI: 10.1007/s40572-025-00494-7.

Peer-Reviewed Original Research

Articles

2026

Leveraging pleiotropy to improve genetic risk prediction across diseases

2025

The role of cardiovascular disease as a mediator in mitigating the impact of ambient PM2.5 on dementia risk

Genome-wide association study of childhood B-cell acute lymphoblastic leukemia reveals novel African ancestry-specific susceptibility loci

Evaluation of disparities in the incidence, presentation, and treatment of pediatric differentiated thyroid cancer in the United States (2000–2022)

8287348 Evaluation and update of an algorithm for quantitatively estimating non-occupational pesticide exposure for spouses in the agricultural health study

Incorporating additive genetic effects and linkage disequilibrium information to discover gene-environment interactions using BV-LDER-GE

A Hypothetical PM2.5 Intervention for the Risk of Hospitalization for Cardiovascular Diseases

A systematic review of residential proximity to upstream oil and gas development and childhood, adolescent and young adult cancer risk

Paternal and maternal exposures to per- and polyfluoroalkyl substances (PFAS) and birth outcomes: a multi-country cohort study

Perinatal Exposures to Ambient Fine Particulate Matter and Outdoor Artificial Light at Night and Risk of Pediatric Papillary Thyroid Cancer

Leveraging Alzheimer’s Disease Omics to Identify Pleiotropic Genes Contributing to Neurodegeneration in Primary Open-Angle Glaucoma

A Narrative Review of Spatial–Temporal Data Sources for Estimating Population-Level Exposures to Oil and Gas Development in the United States

Estimating the Effects of Hypothetical Ambient PM2.5 Interventions on the Risk of Dementia Using the Parametric g-Formula in the UK Biobank Cohort

Paternal and Maternal Exposures to Per- and Polyfluoroalkyl Substances and Child Behavioral Difficulties: A Parental Comparison Study

Perinatal exposure to ambient fine particle air pollution and risk of childhood ewing sarcoma in a population-based case-control study in California (1988–2015)

Mendelian non-syndromic and syndromic hearing loss genes contribute to presbycusis

The case-only design is a powerful approach to detect interactions but should be used with caution

Demographic inequities and cumulative environmental burdens within communities near superfund sites on Long Island, New York

Acetaminophen Use in Pregnancy: A Comparison of Self-Reported Intake with Maternal and Newborn Biomarker Measures

Metrics of Urbanicity and Rurality in US-Based Epidemiologic Studies of Ambient Temperature and Health: A Scoping Review

2024

Domestic groundwater wells in Appalachia show evidence of low-dose, complex mixtures of legacy pollutants

Effects of ambient temperature on mental and neurological conditions in older adults: A systematic review and meta-analysis

Association Between Environmental Air Pollution and Thyroid Cancer and Nodules: A Systematic Review

OncoSexome: the landscape of sex-based differences in oncologic diseases

Quantitative measures of recent and lifetime agricultural pesticide use are associated with increased pesticide concentrations in house dust