Yuan Huang, PhD
Assistant Professor of Biostatistics (Biostatistics)Cards
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Assistant Professor of Biostatistics (Biostatistics)
Biography
Yuan Huang is an Assistant Professor in the Department of Biostatistics at Yale School of Public Health. Her methodological research is focused on statistical methods for high-dimensional data and has been motivated by challenges posted by analyzing cancer genomics, such as low reproducibly, nonlinearity, and heterogeneity. Applications from her work include biomarker identification, large-scale network structure estimation, GxE analysis, etc. She is particularly interested in integrative analysis that simultaneously analyzes multiple datasets to improve the discovery. Recently she collaborates extensively in neurodegenerative diseases and movement disorders, such as Alzheimer's disease, Huntington’s disease, and Parkinson's disease . She is also actively involved in collaborative research on clinical trials, genetics, epidemiology, and other biomedical fields.
Appointments
Biostatistics
Assistant ProfessorPrimary
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Education & Training
- PhD
- The Pennsylvania State University, Statistics
Research
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Public Health Interests
ORCID
0000-0002-8011-3034
Publications
2025
Durability of Respiratory Syncytial Virus Vaccine Effectiveness Among US Veterans
Bajema K, Bui D, Yan L, Li Y, Rajeevan N, Vergun R, Sriskantharajah V, Hynes D, Berry K, Huang Y, Lin H, Aslan M, Ioannou G. Durability of Respiratory Syncytial Virus Vaccine Effectiveness Among US Veterans. JAMA Internal Medicine 2025, 186 PMID: 41284307, PMCID: PMC12645397, DOI: 10.1001/jamainternmed.2025.6355.Peer-Reviewed Original ResearchCitationsAltmetricConceptsRespiratory syncytial virus vaccineRespiratory syncytial virusIntensive care unit admissionRSV vaccineVaccine effectivenessUnit admissionRespiratory syncytial virus illnessSevere respiratory syncytial virusVaccine doseRespiratory syncytial virus infectionMonths of follow-upLong-term effectsHealth care useRespiratory illness seasonVeterans Health AdministrationMatched index dateUrgent care visitsTarget trial emulationMedian ageCare useCare visitsSingle doseSyncytial virusIndex dateVaccine recipientsImpact of time zero designation on estimated COVID-19 antiviral effectiveness in observational studies
Bajema K, Yan L, Berry K, Bui D, Lin H, Huang Y, Li Y, Rajeevan N, Maciejewski M, Smith V, Bohnert A, Hynes D, Aslan M, Ioannou G. Impact of time zero designation on estimated COVID-19 antiviral effectiveness in observational studies. American Journal Of Epidemiology 2025, kwaf221. PMID: 41078178, DOI: 10.1093/aje/kwaf221.Peer-Reviewed Original ResearchMetabolomic biomarkers of rest-activity rhythms in older women: results from the Women’s Health Initiative study
Zhang L, Yeung C, Lee K, Shadyab A, LaCroix A, Stone K, Yaffe K, Hayden K, Casanova R, Rapp S, Chen J, Baker L, Manson J, Huang Y, Xiao Q. Metabolomic biomarkers of rest-activity rhythms in older women: results from the Women’s Health Initiative study. Sleep 2025, zsaf320. PMID: 41071097, DOI: 10.1093/sleep/zsaf320.Peer-Reviewed Original ResearchConceptsIngenuity Pathway AnalysisMetabolomic biomarkersMass spectrometryRest-activity rhythmOlder womenRest-activity rhythm characteristicsLiquid-phase chromatographyTandem mass spectrometryWomen's Health Initiative studyGas chromatography coupled with mass spectrometryWomen's Health InitiativeAssociated with riskUntargeted approachMetabolomics dataAccelerometry dataCardiometabolic diseasesHealth initiativesRest-activity rhythm variablesLinear regression modelsMultiple linear regression modelSerum samplesSpectrometryRhythm variabilityMetabolomicsWomenMetabolomic biomarkers of rest-activity rhythms in older men: results from the Osteoporotic Fractures in Men (MrOS) study
Zhang L, Lee K, Stone K, LaCroix A, Shadyab A, Yaffe K, Redline S, Kado D, Yeung C, Wang S, Huang Y, Xiao Q. Metabolomic biomarkers of rest-activity rhythms in older men: results from the Osteoporotic Fractures in Men (MrOS) study. Sleep 2025, zsaf319. PMID: 41071109, DOI: 10.1093/sleep/zsaf319.Peer-Reviewed Original ResearchConceptsRest-activity rhythm characteristicsIngenuity Pathway AnalysisMetabolomic biomarkersNon-parametric variablesOsteoporotic fracturesOlder menRest-activity rhythmUntargeted approachRhythm characteristicsMetabolomic profilesInflammatory diseasesBlood samplesMen StudyOsteoporoticAdverse health effectsAmino sugar metabolismMetabolitesMenMolecular mechanismsDiseaseLinear regression modelsPathway analysisRhythmActigraphy dataRegression modelsBudget Impact of Adopting Nirmatrelvir-Ritonavir for Treating COVID-19 in a Large Integrated Healthcare System
Bui D, Hynes D, Wong E, Vergun R, Yan L, Li Y, Rajeevan N, Berry K, Lin H, Huang Y, Govier D, Aslan M, Ioannou G, Bajema K. Budget Impact of Adopting Nirmatrelvir-Ritonavir for Treating COVID-19 in a Large Integrated Healthcare System. Open Forum Infectious Diseases 2025, 12: ofaf596. PMID: 41089767, PMCID: PMC12517272, DOI: 10.1093/ofid/ofaf596.Peer-Reviewed Original ResearchAltmetricConceptsVeterans Health AdministrationHealthcare systemEmergency departmentBudget impactRisk quartileIntegrated healthcare systemHealthcare utilization costsHealthcare cost savingsHighest risk quartileTarget trial emulationHealth AdministrationHealthcare costsTrial emulationHealthcareCOVID-19VeteransHospitalTargeted treatmentQuartileClinical subgroupsUtilization costsTreatment benefitTargeted treatment of patientsCost savingsTreatment of patientsEfficacy and Safety of Fecal Microbiota Transplant for Prevention of Recurrent Clostridioides difficile Infection
Shaukat A, Drekonja D, Huang Y, Zhang J, Davis-Karim A, Kyriakides T. Efficacy and Safety of Fecal Microbiota Transplant for Prevention of Recurrent Clostridioides difficile Infection. Clinical Infectious Diseases 2025, 81: e63-e65. PMID: 40260582, DOI: 10.1093/cid/ciaf142.Peer-Reviewed Original ResearchAltmetricSeverity and Long-Term Mortality of COVID-19, Influenza, and Respiratory Syncytial Virus
Bajema K, Bui D, Yan L, Li Y, Rajeevan N, Vergun R, Berry K, Huang Y, Lin H, Aslan M, Ioannou G. Severity and Long-Term Mortality of COVID-19, Influenza, and Respiratory Syncytial Virus. JAMA Internal Medicine 2025, 185: 324-334. PMID: 39869355, PMCID: PMC11773409, DOI: 10.1001/jamainternmed.2024.7452.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRespiratory syncytial virusLong-term mortalitySARS-CoV-2Syncytial virusCohort studyAssociated with higher long-term mortalityRisk differenceIntensive care unit admissionSeasonal influenza vaccineRetrospective cohort studyDisease severity of COVID-19Long-term deathAssociated with more severe disease outcomesRisk of deathCompare disease severitySevere disease outcomesRisk of hospitalizationSeverity of COVID-19Same-day testingInfluenza vaccineInverse probability weightingUnit admissionCumulative incidenceMortality of COVID-19Primary outcomeEffectiveness of the 2023-to-2024 XBB.1.5 COVID-19 Vaccines Over Long-Term Follow-up : A Target Trial Emulation.
Ioannou G, Berry K, Rajeevan N, Li Y, Yan L, Huang Y, Lin H, Bui D, Hynes D, Rowneki M, Bohnert A, Boyko E, Iwashyna T, Maciejewski M, Smith V, Berkowitz T, O'Hare A, Viglianti E, Aslan M, Bajema K. Effectiveness of the 2023-to-2024 XBB.1.5 COVID-19 Vaccines Over Long-Term Follow-up : A Target Trial Emulation. Annals Of Internal Medicine 2025, 178: 348-359. PMID: 39903865, DOI: 10.7326/annals-24-01015.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsU.S. Department of Veterans AffairsDepartment of Veterans AffairsMatched index dateVaccine effectivenessTarget trial emulationSARS-CoV-2-associated deathsRandomized Controlled TrialsCOVID-19 vaccineSARS-CoV-2-related outcomesSARS-CoV-2 testingVeterans AffairsResidual confoundingAbsence of randomized controlled trialsLong-term follow-upDocumented SARS-CoV-2 infectionTrial emulationUnvaccinated personsIndex datePositive resultsControlled TrialsCOVID-19SARS-CoV-2 infectionIncomplete captureHospitalDocumented infectionRespiratory syncytial virus vaccine effectiveness among US veterans, September, 2023 to March, 2024: a target trial emulation study
Bajema K, Yan L, Li Y, Argraves S, Rajeevan N, Fox A, Vergun R, Berry K, Bui D, Huang Y, Lin H, Hynes D, Lucero-Obusan C, Schirmer P, Cunningham F, Huang G, Aslan M, Ioannou G. Respiratory syncytial virus vaccine effectiveness among US veterans, September, 2023 to March, 2024: a target trial emulation study. The Lancet Infectious Diseases 2025, 25: 625-633. PMID: 39848264, DOI: 10.1016/s1473-3099(24)00796-5.Peer-Reviewed Original ResearchCitationsAltmetricConceptsRespiratory syncytial virusRespiratory syncytial virus vaccinePositive RSV testVaccine effectivenessRSV testCare encountersSecondary outcomesEmergency departmentRSV-associated hospitalisationsMedian Follow-UpUS Food and Drug AdministrationHealth-care useVeterans Health AdministrationRespiratory illness seasonMatched index dateElectronic health recordsLower respiratory tract diseaseRSV-related illnessFood and Drug AdministrationDepartment of Veterans Affairs Cooperative Studies ProgramVeterans Affairs Cooperative Studies ProgramCooperative Studies ProgramRSV infectionMedian ageUS Department
2024
Recurrent events modeling based on a reflected Brownian motion with application to hypoglycemia
Xie Y, Fu H, Huang Y, Pozdnyakov V, Yan J. Recurrent events modeling based on a reflected Brownian motion with application to hypoglycemia. Biostatistics 2024, 26: kxae053. PMID: 39865700, DOI: 10.1093/biostatistics/kxae053.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsUpper reflecting barrierBrownian motionReflecting barrierPseudo-marginal likelihoodModel comparison criteriaMarkov chain Monte CarloDeviance information criterionWithin-patient dependenciesRisk factor impactSimulation studyModel selectionDiabetes Self-ManagementInformation criterionRecurrent eventsBayesian frameworkMonte CarloSelf-ManagementControl blood sugarHypoglycemic eventsType 2 diabetesNeurogenic symptomsDURABLE trialPatient heterogeneityComparison criteriaGlucose level variability
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