2022
Incidence, recurring admissions and mortality of severe bacterial infections and sepsis over a 22-year period in the population-based HUNT study
Liyanarachi KV, Solligård E, Mohus RM, Åsvold BO, Rogne T, Damås JK. Incidence, recurring admissions and mortality of severe bacterial infections and sepsis over a 22-year period in the population-based HUNT study. PLOS ONE 2022, 17: e0271263. PMID: 35819970, PMCID: PMC9275692, DOI: 10.1371/journal.pone.0271263.Peer-Reviewed Original ResearchConceptsSevere bacterial infectionsPositive blood culturesBacterial infectionsBlood culturesPopulation-based HUNT StudyPositive blood culture rateTrøndelag Health StudyUrinary tract infectionPopulation-based cohortBlood culture rateCommon infectious diseasesInfectious disease burdenRegistry linkageTract infectionsLoss of healthMedian timeHUNT StudyDisease burdenIncidence rateCulture rateGeneral populationHealth StudyHospitalizationImportant causeTotal burden
2021
Semiquantitative Real-Time PCR to Distinguish Pneumocystis Pneumonia from Colonization in a Heterogeneous Population of HIV-Negative Immunocompromised Patients
Grønseth S, Rogne T, Hannula R, Åsvold BO, Afset JE, Damås JK. Semiquantitative Real-Time PCR to Distinguish Pneumocystis Pneumonia from Colonization in a Heterogeneous Population of HIV-Negative Immunocompromised Patients. Microbiology Spectrum 2021, 9: 10.1128/spectrum.00026-21. PMID: 34346746, PMCID: PMC8552647, DOI: 10.1128/spectrum.00026-21.Peer-Reviewed Original ResearchConceptsSemiquantitative real-time PCRPneumocystis pneumoniaReal-time PCRCutoff valuePCP statusHigher fungal loadHematological malignanciesPneumocystis jiroveciiHIV-negative immunocompromised patientsHuman immunodeficiency virus (HIV) infectionLower respiratory tract specimensRisk of PCPSolid organ transplant recipientsFungal loadHIV Pneumocystis pneumoniaImmunodeficiency virus infectionOrgan transplant recipientsSolid organ recipientsHIV-negative individualsPCR-positive patientsSolid organ transplantationRespiratory tract specimensVulnerable patient populationLife-threatening infectionsAcute respiratory syndromeEpidemiological and clinical characteristics of immunocompromised patients infected with Pneumocystis jirovecii in a twelve-year retrospective study from Norway
Grønseth S, Rogne T, Hannula R, Åsvold BO, Afset JE, Damås JK. Epidemiological and clinical characteristics of immunocompromised patients infected with Pneumocystis jirovecii in a twelve-year retrospective study from Norway. BMC Infectious Diseases 2021, 21: 659. PMID: 34233631, PMCID: PMC8262122, DOI: 10.1186/s12879-021-06144-1.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusRegional incidence ratesRetrospective studyMedical recordsIncidence rateP. jiroveciiTwelve-year retrospective studyMain clinical findingsMajor risk factorPatients' medical recordsHospital mortalityImmunosuppressant usePCP prophylaxisClinical characteristicsMost patientsRadiological featuresPerson yearsClinical findingsImmunodeficiency virusIntensive carePolymerase chain reactionRisk factorsModern chemotherapyCardinal symptomsStudy populationRelationship Between Blood Pressure and Incident Cardiovascular Disease
Malik R, Georgakis MK, Vujkovic M, Damrauer SM, Elliott P, Karhunen V, Giontella A, Fava C, Hellwege JN, Shuey MM, Edwards TL, Rogne T, Åsvold BO, Brumpton BM, Burgess S, Dichgans M, Gill D. Relationship Between Blood Pressure and Incident Cardiovascular Disease. Hypertension 2021, 77: 2004-2013. PMID: 33813844, PMCID: PMC8115430, DOI: 10.1161/hypertensionaha.120.16534.Peer-Reviewed Original ResearchGWAS Identifies LINC01184/SLC12A2 as a Risk Locus for Skin and Soft Tissue Infections
Rogne T, Liyanarachi KV, Rasheed H, Thomas LF, Flatby HM, Stenvik J, Løset M, Gill D, Burgess S, Willer CJ, Hveem K, Åsvold BO, Brumpton BM, DeWan AT, Solligård E, Damås JK. GWAS Identifies LINC01184/SLC12A2 as a Risk Locus for Skin and Soft Tissue Infections. Journal Of Investigative Dermatology 2021, 141: 2083-2086.e8. PMID: 33662382, PMCID: PMC7612997, DOI: 10.1016/j.jid.2021.01.020.Peer-Reviewed Original Research
2020
Body mass index and risk of dying from a bloodstream infection: A Mendelian randomization study
Rogne T, Solligård E, Burgess S, Brumpton BM, Paulsen J, Prescott HC, Mohus RM, Gustad LT, Mehl A, Åsvold BO, DeWan AT, Damås JK. Body mass index and risk of dying from a bloodstream infection: A Mendelian randomization study. PLOS Medicine 2020, 17: e1003413. PMID: 33196656, PMCID: PMC7668585, DOI: 10.1371/journal.pmed.1003413.Peer-Reviewed Original ResearchConceptsBody mass indexHigher body mass indexBloodstream infectionsBSI incidenceBSI mortalityHazard ratioMass indexGeneral populationPopulation-based cohortAnalysis of patientsTerms of mortalityMendelian randomization studyTraditional epidemiological studiesMendelian randomization analysisObesity paradoxMean ageObservational studyEpidemiological studiesRandomization studyCausal associationSepsisMortalityPatientsInfectionRandomization analysisGenome-Wide Linkage Analysis of the Risk of Contracting a Bloodstream Infection in 47 Pedigrees Followed for 23 Years Assembled From a Population-Based Cohort (the HUNT Study).
Rogne T, Damås JK, Solligård E, DeWan AT. Genome-Wide Linkage Analysis of the Risk of Contracting a Bloodstream Infection in 47 Pedigrees Followed for 23 Years Assembled From a Population-Based Cohort (the HUNT Study). Critical Care Medicine 2020, 48: 1580-1586. PMID: 32885941, DOI: 10.1097/ccm.0000000000004520.Peer-Reviewed Original Research
2019
Presenting complaints and mortality in a cohort of 22 000 adult emergency patients at a local hospital in Nepal
Giri S, Rogne T, Uleberg O, Skovlund E, Shrestha SK, Koju R, Damås JK, Solligård E, Risnes KR. Presenting complaints and mortality in a cohort of 22 000 adult emergency patients at a local hospital in Nepal. Journal Of Global Health 2019, 9: 020403. PMID: 31489186, PMCID: PMC6708590, DOI: 10.7189/jogh.09.020403.Peer-Reviewed Original ResearchConceptsLow-resource settingsEmergency departmentAdult emergency patientsPost-discharge mortalityChronic lung diseaseEmergency department populationHealth carePrimary health careEmergency health care systemHealth care needsPost-discharge studyHealth care systemEmergency health careAbdominal complaintsED dischargeAdult patientsMedian ageLung diseaseAppropriate followSex distributionEmergency patientsLocal hospitalCare needsPatientsHigh mortality