Rolando Garcia Milian, MLS, AHIP
Biomedical Sciences Research Support Librarian and Lecturer in EpidemiologyDownloadHi-Res Photo
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Additional Titles
Bioinformatics Support, Fellow of Ezra Stiles College, Medical Library
Publications Overview
- 72 Publications
- 1,170 Citations
- 87 Yale Co-Authors
Contact Info
Cushing/Whitney Medical Library
PO Box 208014, 333 Cedar St
New Haven, CT 06520
United States
Additional Titles
Bioinformatics Support, Fellow of Ezra Stiles College, Medical Library
Publications Overview
- 72 Publications
- 1,170 Citations
- 87 Yale Co-Authors
Contact Info
Cushing/Whitney Medical Library
PO Box 208014, 333 Cedar St
New Haven, CT 06520
United States
Additional Titles
Bioinformatics Support, Fellow of Ezra Stiles College, Medical Library
Publications Overview
- 72 Publications
- 1,170 Citations
- 87 Yale Co-Authors
Contact Info
Cushing/Whitney Medical Library
PO Box 208014, 333 Cedar St
New Haven, CT 06520
United States
About
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Titles
Biomedical Sciences Research Support Librarian and Lecturer in Epidemiology
Bioinformatics Support, Fellow of Ezra Stiles College, Medical Library
Biography
Rolando oversees the Yale Medical Library Bioinformatics Support Program and is Lecturer in Epidemiology for the Environmental Health Sciences (EHS) Department, Yale School of Public Health. This end-user-centered bioinformatics program provides resources, training, consultations, and collaboration to biomedical sciences researchers at Yale including finding, retrieving, analyzing and sharing molecular datasets.
Last Updated on March 25, 2025.
Appointments
Environmental Health Sciences
LecturerSecondary
Other Departments & Organizations
- Cushing/Whitney Medical Library
- Environmental Health Sciences
- NIDA Neuroproteomics Center
- Yale School of Public Health
- Yale-BI Biomedical Data Science Fellowship
Education & Training
- Biomedical Informatics Fellow
- Marine Biological Laboratory/ National Library of Medicine (2012)
- MLS
- Southern Connecticut State University (2012)
Research
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Overview
Medical Research Interests
Chemicals and Drugs; Diseases; Genomics; Information Science; Metabolomics; Proteomics
Public Health Interests
Genetics, Genomics, Epigenetics; Toxicology
ORCID
0000-0003-1557-566XBioinformatics Support Hub
The Bioinformatics Support Hub provides resources, training, consultation, and collaboration for omics data analysis.
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Rolando Garcia Milian's published research.
Publications Timeline
A big-picture view of Rolando Garcia Milian's research output by year.
Research Interests
Research topics Rolando Garcia Milian is interested in exploring.
David Thompson
TuKiet Lam, PhD, BS
Ying Chen, MD, PhD
Caroline Helen Johnson, PhD
Georgia Charkoftaki, PharmD, PhD
Xingguang Luo, MD
72Publications
1,170Citations
Proteomics
Metabolomics
Publications
Featured Publications
Peer Teaching as Bioinformatics Training Strategy: Incentives, Challenges, and Benefits
Rahman NT, Meyer C, Thakral D, Cai WL, Chen AT, Obaid R, Garcia-Milian R. Peer Teaching as Bioinformatics Training Strategy: Incentives, Challenges, and Benefits. Medical Reference Services Quarterly 2022, 41: 13-25. PMID: 35225737, DOI: 10.1080/02763869.2022.2020568.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsPeer teachingProfessional development opportunitiesResearch-intensive institutionsPeer teachersClassroom managementLack of timeTeachingCommunication skillsDevelopment opportunitiesTeachersComplex conceptBioinformatics trainingPersonal experienceTraining strategySkillsChallengesPeersTraineesInstitutionsWorkshopTrainingExperienceConfidenceOpportunitiesTopic
2025
In Vivo PET Imaging of Preynaptic Density Reveals Stress-Associated Synaptic Deficits Related to Behavioral and Molecular Alterations in Rats
Asch R, Hernandez Martin N, Garcia-Milian R, Fowles K, DiLeone R, Cai Z, Liston C, Esterlis I. In Vivo PET Imaging of Preynaptic Density Reveals Stress-Associated Synaptic Deficits Related to Behavioral and Molecular Alterations in Rats. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 41038318, DOI: 10.1016/j.bpsc.2025.09.021.Peer-Reviewed Original ResearchConceptsNovel object recognitionPrefrontal cortexPositron emission tomographySucrose preferenceSynaptic densityChronic stressExposed to chronic unpredictable stressIn vivo PET imagingRodent models of chronic stressModel of chronic stressFemale Long-Evans ratsChronic unpredictable stressIn vivo positron emission tomographyStress-related pathologiesLong-Evans ratsRodent modelsRats relative to controlsIn vivo quantificationRelative to controlsUnpredictable stressBehavioral phenotypesSynaptic deficitsHippocampal proteinsSynaptic density changesSynaptic vesicle protein 2ADistinct metabolic and genetic alterations in tumors from early-onset versus late-onset colorectal cancer
Janak A, Jain A, Garcia-Milian R, Aladelokun O, Ma X, Paty P, Khan S, Johnson C. Distinct metabolic and genetic alterations in tumors from early-onset versus late-onset colorectal cancer. Free Radical Biology And Medicine 2025, 240: 773-782. PMID: 40865779, DOI: 10.1016/j.freeradbiomed.2025.08.052.Peer-Reviewed Original ResearchAltmetricConceptsLate-onset colorectal cancerEO-CRCColorectal cancerTumor metabolomeMass spectrometry-based untargeted metabolomicsTumor tissuesCatecholamine metabolismGroup of CRC patientsMetabolite set enrichment analysisPatient-matched normal tissuesTumor-specific differencesEarly-onset colorectal cancerMetabolite of dopaminePD-L1Untargeted metabolomicsCRC patientsOxidative stress-related genesHomovanillic acidGenetic alterationsEarly-onsetTumorTherapeutic strategiesGene expression validationNormal tissuesEGFR SignalingThe Proteomic Landscape of Parkin-Deficient and Parkin-Overexpressing Rat Nucleus Accumbens: An Insight into the Role of Parkin in Methamphetamine Use Disorder
Sharma A, Atasi T, Collin F, Wang W, Lam T, Garcia-Milian R, Arroum T, Pham L, Hüttemann M, Moszczynska A. The Proteomic Landscape of Parkin-Deficient and Parkin-Overexpressing Rat Nucleus Accumbens: An Insight into the Role of Parkin in Methamphetamine Use Disorder. Biomolecules 2025, 15: 958. PMID: 40723830, PMCID: PMC12292523, DOI: 10.3390/biom15070958.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsMETH use disorderMethamphetamine use disorderNucleus accumbensAddictive behaviorsUse disorderAdult Long-Evans male ratsLong-Evans male ratsProteomic landscapeRat nucleus accumbensMale ratsFDA-approved pharmacotherapiesActin cytoskeleton dynamicsYoung adult male ratsDrug targetsAdult male ratsAMPA receptor traffickingRat modelLabel-free proteomicsGABAergic neurotransmissionCytoskeleton dynamicsMethamphetamineUbiquitinated proteinsMitochondrial respirationAccumbensParkin deficiencyProliferative arrest induces neuronal differentiation and innate immune responses in normal and Creutzfeldt-Jakob Disease agent (CJ) infected rat septal neurons
Pagano N, Perez G, Garcia-Milian R, Manuelidis L. Proliferative arrest induces neuronal differentiation and innate immune responses in normal and Creutzfeldt-Jakob Disease agent (CJ) infected rat septal neurons. PLOS ONE 2025, 20: e0323825. PMID: 40434970, PMCID: PMC12118874, DOI: 10.1371/journal.pone.0323825.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsSeptal neuronsInnate immune responseDifferential transcriptionCreutzfeldt-Jakob disease agentCJ infectionImmune responseBind misfolded proteinsInnate immune genesIntestinal myeloid cellsRat septal neuronsArrests normal cellsDisease agentsInnate immune transcriptsCreutzfeldt-JakobModel of latent infectionAnti-viral responseCDNA libraryUnique transcriptsPeripheral human bloodLate-onset diseaseUninfected neuronsUpregulated interferonImmune genesMyeloid cellsTranscription270. Sex-Differences in Molecular and Synaptic Mechanisms Contributing to Stress-Related pathology: Insight from a Synaptic Density Pet and Proteomic Study in Rats
Asch R, Garcia-Milian R, Hernandez-Martin N, Cai Z, Esterlis I. 270. Sex-Differences in Molecular and Synaptic Mechanisms Contributing to Stress-Related pathology: Insight from a Synaptic Density Pet and Proteomic Study in Rats. Biological Psychiatry 2025, 97: s207. DOI: 10.1016/j.biopsych.2025.02.508.Peer-Reviewed Original ResearchTranscriptomic landscape of cumulus cells from patients <38 years old with a history of poor ovarian response (POR) treated with platelet-rich plasma (PRP)
Roberts L, Herlihy N, Reig A, Titus S, Garcia-Milian R, Knight J, Yildirim R, Margolis C, Cakiroglu Y, Tiras B, Whitehead C, Werner M, Seli E. Transcriptomic landscape of cumulus cells from patients <38 years old with a history of poor ovarian response (POR) treated with platelet-rich plasma (PRP). Aging 2025, 17: 431-447. PMID: 39976580, PMCID: PMC11892918, DOI: 10.18632/aging.206202.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPlatelet-rich plasmaTreated with platelet-rich plasmaCumulus cellsPoor ovarian responseLive birthsGene expressionIntraovarian injection of autologous platelet-rich plasmaPatients treated with platelet-rich plasmaInjection of autologous platelet-rich plasmaHistory of poor ovarian responseAutologous platelet-rich plasmaPlatelet-rich plasma treatmentDiminished ovarian reserveCell-to-cell signalingRNA sequencing librariesCause of infertilityDifferential expression analysisFalse discovery rate thresholdIntraovarian injectionOvarian reserveFailed implantsSequencing librariesOvarian responseTranscriptomic landscapeRNA sequencing
2024
Hormone Receptor-Positive HER2-Negative/MammaPrint High-2 Breast Cancers Closely Resemble Triple-Negative Breast Cancers.
Rios-Hoyo A, Xiong K, Dai J, Yau C, Marczyk M, Garcia-Milian R, Wolf D, Huppert L, Nanda R, Hirst G, Cobain E, van 't Veer L, Esserman L, Pusztai L. Hormone Receptor-Positive HER2-Negative/MammaPrint High-2 Breast Cancers Closely Resemble Triple-Negative Breast Cancers. Clinical Cancer Research 2024, 31: 403-413. PMID: 39561272, PMCID: PMC11747811, DOI: 10.1158/1078-0432.ccr-24-1553.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPathological complete responseEvent-free survivalBreast cancerHER2 negative breast cancerHormone receptor-positive/HER2-negativePathologic complete response ratePrognostic risk categoriesTN breast cancerNegative breast cancerGene set analysisExpression of cell cycleGene expression dataLow-risk subgroupsHigh-risk groupMammaPrint assayNeoadjuvant trialsComplete responseER statusResidual cancerPrognostic groupsClinical featuresI-SPY2Prognostic assaysExpression dataTreatment strategiesProteomic Profile of Circulating Extracellular Vesicles in the Brain after Δ9-Tetrahydrocannabinol Inhalation
Lallai V, Lam T, Garcia-Milian R, Chen Y, Fowler J, Manca L, Piomelli D, Williams K, Nairn A, Fowler C. Proteomic Profile of Circulating Extracellular Vesicles in the Brain after Δ9-Tetrahydrocannabinol Inhalation. Biomolecules 2024, 14: 1143. PMID: 39334909, PMCID: PMC11430348, DOI: 10.3390/biom14091143.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsImmediate early gene c-fosChronic THC exposureEarly gene c-fosCannabinoid 1 receptorGene c-fosSex-specific mannerTHC exposurePsychoactive componentExtracellular vesiclesCentral signaling mechanismDrug effectsTHCChoroid plexus epithelial cellsFemale ratsC-fosPlexus epithelial cellsBrainCannabisRelease of EVsRegulate intercellular communicationCerebrospinal fluidEpithelial cellsIntercellular signaling mediatorsEV signalingIntercellular communicationThe human CD47 checkpoint is targeted by an immunosuppressive Aedes aegypti salivary factor to enhance arboviral skin infectivity
Marin-Lopez A, Huck J, Esterly A, Azcutia V, Rosen C, Garcia-Milian R, Sefik E, Vidal-Pedrola G, Raduwan H, Chen T, Arora G, Halene S, Shaw A, Palm N, Flavell R, Parkos C, Thangamani S, Ring A, Fikrig E. The human CD47 checkpoint is targeted by an immunosuppressive Aedes aegypti salivary factor to enhance arboviral skin infectivity. Science Immunology 2024, 9: eadk9872-eadk9872. PMID: 39121194, PMCID: PMC11924945, DOI: 10.1126/sciimmunol.adk9872.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSuppress antiviral responsesArthropod proteinsPathogen replicationAntiviral responseProtein AVertebrate hostsMosquito salivary proteinsUp-regulatedBlood feedingHuman macrophagesPleomorphic effectsSkin infectionsZika virus disseminationInhibit proinflammatory responsesSalivary proteinsProteinNatural ligandWhite blood cellsHuman skin explantsProinflammatory responseMosquito salivaVirus disseminationHuman CD47Salivary factorsArbovirus infection
Academic Achievements & Community Involvement
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Activities
activity Academy of Health Information Professionals
04/15/2018 - PresentProfessional OrganizationsCommittee Memberactivity International Society for Computational Biology
2020 - PresentProfessional OrganizationsMemberactivity Institutional Animal Care & Use Committee
06/01/2014 - 05/01/2018CommitteesCommittee Member
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- Network representation of the research articles resulting from collaborations between Medical Library Bioinformatics Support Program and groups/departments at the YSM
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Cushing/Whitney Medical Library
PO Box 208014, 333 Cedar St
New Haven, CT 06520
United States
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Sterling Hall of Medicine
333 Cedar Street, Rm SHM L-103
New Haven, CT 06510