2024
Associations between fasting glucose rate-of-change and the missense variant, rs373863828, in an adult Samoan cohort
Rivara A, Russell E, Carlson J, Pomer A, Naseri T, Reupena M, Manna S, Viali S, Minster R, Weeks D, DeLany J, Kershaw E, McGarvey S, Hawley N. Associations between fasting glucose rate-of-change and the missense variant, rs373863828, in an adult Samoan cohort. PLOS ONE 2024, 19: e0302643. PMID: 38829901, PMCID: PMC11146712, DOI: 10.1371/journal.pone.0302643.Peer-Reviewed Original ResearchConceptsType 2 diabetesAllele of rs373863828Body mass indexFasting glucoseAdult SamoansDevelopment of type 2 diabetesOdds of type 2 diabetesReduction of modifiable risk factorsRs373863828 genotypeAssociated with higher body mass indexType 2 diabetes developmentGlucose rate of changeMass indexHousehold asset scoreUrbanization of residenceHigher body mass indexRisk factorsModifiable risk factorsRate of changeBaseline variablesMultivariate linear regressionPhysical activityDiabetes preventionType 2 diabetes mellitusSmoking status
2023
Identifying patient preferences for diabetes care: A protocol for implementing a discrete choice experiment in Samoa
Rivara A, Galárraga O, Selu M, Arorae M, Wang R, Faasalele-Savusa K, Rosen R, Hawley N, Viali S. Identifying patient preferences for diabetes care: A protocol for implementing a discrete choice experiment in Samoa. PLOS ONE 2023, 18: e0295845. PMID: 38134044, PMCID: PMC10745180, DOI: 10.1371/journal.pone.0295845.Peer-Reviewed Original Research
2022
CREBRF missense variant rs373863828 has both direct and indirect effects on type 2 diabetes and fasting glucose in Polynesian peoples living in Samoa and Aotearoa New Zealand
Russell EM, Carlson JC, Krishnan M, Hawley NL, Sun G, Cheng H, Naseri T, Reupena M, Viali S, Tuitele J, Major TJ, Miljkovic I, Merriman TR, Deka R, Weeks DE, McGarvey ST, Minster RL. CREBRF missense variant rs373863828 has both direct and indirect effects on type 2 diabetes and fasting glucose in Polynesian peoples living in Samoa and Aotearoa New Zealand. BMJ Open Diabetes Research & Care 2022, 10: e002275. PMID: 35144939, PMCID: PMC8845200, DOI: 10.1136/bmjdrc-2021-002275.Peer-Reviewed Original ResearchConceptsBody mass indexType 2 diabetesAssociation of BMIHigher body mass indexMinor alleleType 2 diabetes riskCross-sectional associationsPacific Island populationsRs373863828 genotypeMass indexDiabetes riskHigher oddsLower oddsDiabetesObesityEvidence of differencesMissense variantsRs373863828Regression analysisGlucoseAssociationOddsIndirect effectsPolynesian individuals
2020
A missense variant in CREBRF, rs373863828, is associated with fat-free mass, not fat mass in Samoan infants
Arslanian KJ, Fidow UT, Atanoa T, Unasa-Apelu F, Naseri T, Wetzel AI, Pomer A, Duckham RL, McGarvey ST, Strayer JA, Kershaw EE, Weeks DE, Hawley NL. A missense variant in CREBRF, rs373863828, is associated with fat-free mass, not fat mass in Samoan infants. International Journal Of Obesity 2020, 45: 45-55. PMID: 32884101, PMCID: PMC8329753, DOI: 10.1038/s41366-020-00659-4.Peer-Reviewed Original ResearchConceptsBody mass indexDual-energy X-ray absorptiometrySamoan infantsBone massFat massLean massEarly infantsBody compositionInfant body mass indexMinor alleleDeterminants of adiposityOdds of diabetesBone mass accretionMissense variantsX-ray absorptiometryFat-free massCross-sectional analysisMore bone massCREBRF variantProspective studyHigher oddsEarly infancyInfantsAdult populationNatural historyGenome-wide association studies in Samoans give insight into the genetic architecture of fasting serum lipid levels
Carlson JC, Weeks DE, Hawley NL, Sun G, Cheng H, Naseri T, Reupena M, Tuitele J, Deka R, McGarvey ST, Minster RL. Genome-wide association studies in Samoans give insight into the genetic architecture of fasting serum lipid levels. Journal Of Human Genetics 2020, 66: 111-121. PMID: 32759990, PMCID: PMC7785639, DOI: 10.1038/s10038-020-0816-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultApolipoprotein A-IApolipoproteins ECholesterol Ester Transfer ProteinsCholesterol, HDLCholesterol, LDLCohort StudiesFastingFemaleGenetic MarkersGenome-Wide Association StudyHumansLipid MetabolismLipidsMaleMiddle AgedPolymorphism, Single NucleotideQuantitative Trait LociSamoaTriglyceridesConceptsGenome-wide association studiesGenetic architectureAssociation studiesGenome-wide significant associationDifferent association signalsUnique population historyPopulation bottlenecksLipid lociPopulation historyAssociation signalsSuggestive associationRab21Current understandingMGAT1Association of variantsReplication cohortLipidsBiological foundationsVariantsLociLow-density lipoproteinInsightsPopulationLipid levelsHigh-density lipoproteinPiloting a food photo sorting activity in Samoa to assess maternal beliefs and their role in child diet
Tanawattanacharoen VK, Choy CC, Anesi TJ, Naseri T, Soti‐Ulberg C, Reupena MS, Hawley NL. Piloting a food photo sorting activity in Samoa to assess maternal beliefs and their role in child diet. Maternal And Child Nutrition 2020, 16: e12974. PMID: 32056393, PMCID: PMC7296816, DOI: 10.1111/mcn.12974.Peer-Reviewed Original ResearchConceptsChildren's dietary intakeDietary intakeChildhood obesityChildren's dietsHealthier child dietMaternal beliefsAlarming burdenSamoan mothersKnowledge/beliefsNutritional knowledgeEating habitsNutritional expertsIntakeHealthy foodsMothersObesityCountry settingsCost of foodStatusDietPearson correlationFood costsAdditional supportParental beliefsFood
2016
A thrifty variant in CREBRF strongly influences body mass index in Samoans
Minster RL, Hawley NL, Su CT, Sun G, Kershaw EE, Cheng H, Buhule OD, Lin J, Reupena MS, Viali S, Tuitele J, Naseri T, Urban Z, Deka R, Weeks DE, McGarvey ST. A thrifty variant in CREBRF strongly influences body mass index in Samoans. Nature Genetics 2016, 48: 1049-1054. PMID: 27455349, PMCID: PMC5069069, DOI: 10.1038/ng.3620.Peer-Reviewed Original Research