2001
Methylprednisolone and Acute Spinal Cord Injury
Bracken M. Methylprednisolone and Acute Spinal Cord Injury. Spine 2001, 26: s47-s54. PMID: 11805609, DOI: 10.1097/00007632-200112151-00010.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryCord injuryMethodologic qualitySystematic reviewImproved functional recoveryHigh methodologic qualityNeurologic recoveryClinical recoveryPharmacologic therapyFunctional recoveryRandomized trialsInjury trialsCochrane LibraryEffective therapySurgical trialsEarly treatmentFurther trialsTherapeutic interventionsInjuryMeSH headingsMethylprednisoloneScore improvementPatientsEvidence baseSummary Statement: The Sygen® (GM-1 Ganglioside) Clinical Trial in Acute Spinal Cord Injury
Fehlings M, Bracken M. Summary Statement: The Sygen® (GM-1 Ganglioside) Clinical Trial in Acute Spinal Cord Injury. Spine 2001, 26: s99-s100. PMID: 11805615, DOI: 10.1097/00007632-200112151-00016.Commentaries, Editorials and Letters
1998
Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial.
Bracken M, Shepard M, Holford T, Leo-Summers L, Aldrich E, Fazl M, Fehlings M, Herr D, Hitchon P, Marshall L, Nockels R, Pascale V, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial. Journal Of Neurosurgery 1998, 89: 699-706. PMID: 9817404, DOI: 10.3171/jns.1998.89.5.0699.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryHours of injuryCord injuryFunctional recoveryRandomized double-blind clinical trialMortality rate 1 yearDouble-blind clinical trialMotor function recoveryMP regimenMotor recoveryMP therapyTherapy 3Neurological gradeMorbidity rateSphincter controlFunction recoveryMethylprednisolone regimenClinical trialsMedical factorsTreatment groupsPatientsRegimenInjurySelf-Care
1992
Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study.
Bracken M, Shepard M, Collins W, Holford T, Baskin D, Eisenberg H, Flamm E, Leo-Summers L, Maroon J, Marshall L, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study. Journal Of Neurosurgery 1992, 76: 23-31. PMID: 1727165, DOI: 10.3171/jns.1992.76.1.0023.Peer-Reviewed Original ResearchConceptsHours of injuryAcute spinal cord injurySpinal cord injuryNaloxone treatmentCord injuryMotor functionSecond National Acute Spinal Cord Injury StudyNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudySpinal Cord Injury StudyAcute spinal cord traumaPreservation of motorTrial of methylprednisoloneSpinal cord traumaTotal sensoryPlacebo groupCord traumaNeurological functionStudy doseEmergency roomMethylprednisoloneInjury studiesMortality ratePatientsSensory function
1991
Treatment of acute spinal cord injury with methylprednisolone: results of a multicenter, randomized clinical trial.
Bracken M. Treatment of acute spinal cord injury with methylprednisolone: results of a multicenter, randomized clinical trial. Journal Of Neurotrauma 1991, 8 Suppl 1: s47-50; discussion s51-2. PMID: 1920461.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryCord injuryAdministration of methylprednisoloneApparent contraindicationsNeurological improvementClinical trialsPermanent paralysisMethylprednisoloneLow dosesInjuryAdministrationDosesTrialsTreatmentMulticenterPlaceboContraindicationsNaloxoneParalysisDose
1990
Methylprednisolone for acute spinal cord injury
Leake G, Pascale V, Alfano S, Bracken M. Methylprednisolone for acute spinal cord injury. American Journal Of Health-System Pharmacy 1990, 47: 1977-1978. PMID: 2220844, DOI: 10.1093/ajhp/47.9.1977.Peer-Reviewed Original ResearchA Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury
Bracken M, Shepard M, Collins W, Holford T, Young W, Baskin D, Eisenberg H, Flamm E, Leo-Summers L, Maroon J, Marshall L, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H. A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury. New England Journal Of Medicine 1990, 322: 1405-1411. PMID: 2278545, DOI: 10.1056/nejm199005173222001.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryNeurologic recoverySafety of methylprednisoloneSystematic neurological examinationPlacebo-controlled trialHours of injuryMajor morbidityNeurologic outcomeControlled TrialsNeurological examinationIncomplete lesionsMotor functionMethylprednisoloneNaloxonePatientsBody weightSensory functionInjuryPlaceboInfusionBolusEffective remainsTreatmentDose
1984
Efficacy of Methylprednisolone in Acute Spinal Cord Injury
Bracken M, Collins W, Freeman D, Shepard M, Wagner F, Silten R, Hellenbrand K, Ransohoff J, Hunt W, Perot P, Grossman R, Green B, Eisenberg H, Rifkinson N, Goodman J, Meagher J, Fischer B, Clifton G, Flamm E, Rawe S. Efficacy of Methylprednisolone in Acute Spinal Cord Injury. JAMA 1984, 251: 45-52. PMID: 6361287, DOI: 10.1001/jama.1984.03340250025015.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryCord injuryEarly case fatalityEfficacy of methylprednisoloneHigh-dose regimenLight touch sensationHigh-dose protocolGroups six weeksNeurological recoveryCase fatalityWound infectionStandard doseMotor functionInitial lesionHigh doseOperative siteSix weeksInjuryMethylprednisoloneTreatment effectsTouch sensationDoseEfficacyMulticenter
1981
Psychological response to acute spinal cord injury: an epidemiological study
Bracken M, Shepard M, Webb S. Psychological response to acute spinal cord injury: an epidemiological study. Spinal Cord 1981, 19: 271-283. PMID: 7279429, DOI: 10.1038/sc.1981.53.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCord injuryAcute spinal cord injurySeverity of motorTime of dischargeAcute care hospitalsAcute hospitalisationNeurological statusCare hospitalNeurological functionPsychological reactionsEpidemiological studiesRehabilitation therapyInjuryNegative coping responsesHospitalisationPsychological counsellingSensory disabilitiesPersonality reactionsPsychological responsesLesser degreeCoping reactionsPatientsAdmissionHospital
1980
Relationship between neurological and functional status after acute spinal cord injury: An epidemiological study
Bracken M, Hildreth N, Freeman D, Webb S. Relationship between neurological and functional status after acute spinal cord injury: An epidemiological study. Journal Of Clinical Epidemiology 1980, 33: 115-125. PMID: 7354100, DOI: 10.1016/0021-9681(80)90035-1.Peer-Reviewed Original ResearchConceptsSensory functionMotor functionFunctional statusFirst post-injury yearAcute spinal cord injurySpinal cord injurySelfcare activitiesFour-point scaleADL scoresHospital dischargeHospital admissionSensory lossNeurological functionProspective studyCord injuryDaily livingEpidemiological studiesMovement of limbsHospitalizationPatientsInjuryGreater improvementAdditive effectSignificant improvementStatus
1978
Classification of the severity of acute spinal cord injury: implications for management
Bracken M, Webb S, Wagner F. Classification of the severity of acute spinal cord injury: implications for management. Spinal Cord 1978, 15: 319-326. PMID: 625431, DOI: 10.1038/sc.1977.48.Peer-Reviewed Original ResearchConceptsSpinal cord injuryAcute spinal cord injuryCord injuryMotor functionBrown-Sequard syndromeMotor function scalesPoor motor functionComprehensive neurological examinationDifferent therapeutic modalitiesSevere motor impairmentAcute hospitalisationCord lesionsNeurological examinationFracture dislocationSensory lossProspective studyEmergency departmentHigh prevalenceTherapeutic modalitiesMotor impairmentSensory functionPatientsFunction scaleOlder ageInjury