1985
Methylprednisolone and neurological function 1 year after spinal cord injury. Results of the National Acute Spinal Cord Injury Study.
Bracken M, Shepard M, Hellenbrand K, Collins W, Leo L, Freeman D, Wagner F, Flamm E, Eisenberg H, Goodman J, Perot P, Green B, Grossman R, Meagher J, Young W, Fischer B, Clifton G, Hunt W, Rifkinson N. Methylprednisolone and neurological function 1 year after spinal cord injury. Results of the National Acute Spinal Cord Injury Study. Journal Of Neurosurgery 1985, 63: 704-13. PMID: 3903070, DOI: 10.3171/jns.1985.63.5.0704.Peer-Reviewed Original ResearchConceptsTotal steroid doseNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudySpinal Cord Injury StudyHigh-dose methylprednisoloneSteroid treatment protocolFunction 1 yearCase fatality rateSpinal cord injuryPinprick responseSteroid doseNeurological recoveryCord injuryStandard dosePatient genderClinical trialsMotor functionTreatment protocolStudy groupInjury studiesTreatment groupsFatality rateInjuryMethylprednisoloneTreatment effects
1984
Efficacy of Methylprednisolone in Acute Spinal Cord Injury
Bracken M, Collins W, Freeman D, Shepard M, Wagner F, Silten R, Hellenbrand K, Ransohoff J, Hunt W, Perot P, Grossman R, Green B, Eisenberg H, Rifkinson N, Goodman J, Meagher J, Fischer B, Clifton G, Flamm E, Rawe S. Efficacy of Methylprednisolone in Acute Spinal Cord Injury. JAMA 1984, 251: 45-52. PMID: 6361287, DOI: 10.1001/jama.1984.03340250025015.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryCord injuryEarly case fatalityEfficacy of methylprednisoloneHigh-dose regimenLight touch sensationHigh-dose protocolGroups six weeksNeurological recoveryCase fatalityWound infectionStandard doseMotor functionInitial lesionHigh doseOperative siteSix weeksInjuryMethylprednisoloneTreatment effectsTouch sensationDoseEfficacyMulticenter