2008
Fetal Heart Rate Monitoring Patterns in Women with Amniotic Fluid Proteomic Profiles Indicative of Inflammation
Buhimschi C, Abdel-Razeq S, Cackovic M, Pettker C, Dulay A, Bahtiyar M, Zambrano E, Martin R, Norwitz E, Bhandari V, Buhimschi I. Fetal Heart Rate Monitoring Patterns in Women with Amniotic Fluid Proteomic Profiles Indicative of Inflammation. American Journal Of Perinatology 2008, 25: 359-372. PMID: 18512201, PMCID: PMC2724874, DOI: 10.1055/s-2008-1078761.Peer-Reviewed Original ResearchConceptsEarly-onset neonatal sepsisIntra-amniotic inflammationFetal heart rate monitoring patternsHistological chorioamnionitisPreterm birthPredictive valueAcute histological chorioamnionitisFetuses of womenHuman Development criteriaUseful clinical indicatorNegative predictive valuePositive predictive valueMonitoring patternsNeonatal sepsisPremature neonatesGestational ageLaboratory criteriaAntibiotic treatmentClinical indicatorsChild healthSensitive predictorInflammationAdmissionNeonatesInitial evaluationNucleated red blood cells are a direct response to mediators of inflammation in newborns with early-onset neonatal sepsis
Dulay AT, Buhimschi IA, Zhao G, Luo G, Abdel-Razeq S, Cackovic M, Rosenberg VA, Pettker CM, Thung SF, Bahtiyar MO, Bhandari V, Buhimschi CS. Nucleated red blood cells are a direct response to mediators of inflammation in newborns with early-onset neonatal sepsis. American Journal Of Obstetrics And Gynecology 2008, 198: 426.e1-426.e9. PMID: 18395034, PMCID: PMC4023236, DOI: 10.1016/j.ajog.2008.01.040.Peer-Reviewed Original ResearchConceptsEarly-onset neonatal sepsisNucleated red blood cellsInflammation-associated preterm birthNRBC countAcid-base statusIntraamniotic inflammationHistological chorioamnionitisNeonatal sepsisRed blood cellsPreterm birthGestational ageCord blood IL-6 levelsBlood IL-6 levelsFetal acid-base statusBlood cellsAbsolute NRBC countsIL-6 levelsEarly neonatal periodIntrauterine growth restrictionHours of birthEarlier gestational ageMediators of inflammationMinutes of deliveryAbsence of hypoxiaPreterm singletons
2007
Proteomic Profiling of the Amniotic Fluid to Detect Inflammation, Infection, and Neonatal Sepsis
Buhimschi CS, Bhandari V, Hamar BD, Bahtiyar MO, Zhao G, Sfakianaki AK, Pettker CM, Magloire L, Funai E, Norwitz ER, Paidas M, Copel JA, Weiner CP, Lockwood CJ, Buhimschi IA. Proteomic Profiling of the Amniotic Fluid to Detect Inflammation, Infection, and Neonatal Sepsis. PLOS Medicine 2007, 4: e18. PMID: 17227133, PMCID: PMC1769412, DOI: 10.1371/journal.pmed.0040018.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmniocentesisAmniotic FluidBiomarkersFemaleHumansInflammationMiddle AgedPregnancyPregnancy Complications, InfectiousPregnancy OutcomeProteomeProteomicsReproducibility of ResultsSensitivity and SpecificitySepsisSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationConceptsEarly-onset neonatal sepsisAmniotic fluid inflammationIntra-amniotic infectionMR scoreNeonatal sepsisAmniotic fluidHistological chorioamnionitisDelivery intervalNewborn Special Care UnitGram stainEarly-onset sepsisIntra-amniotic inflammationDegree of inflammationSpecial care unitsIntrauterine inflammationPlacental inflammationShorter amniocentesisPreterm deliveryPreterm laborSingleton pregnanciesConsecutive womenPreterm birthCare unitGestational agePremature rupture