2016
Evidence for participation of neutrophil gelatinase‐associated lipocalin/matrix metalloproteinase‐9 (NGAL•MMP‐9) complex in the inflammatory response to infection in pregnancies complicated by preterm birth
Rood KM, Buhimschi IA, Rodewald Millen K, Bahtiyar MO, Thung S, Summerfield T, Zhao G, Ackerman W, Shellhaas C, Samuels P, Buhimschi CS. Evidence for participation of neutrophil gelatinase‐associated lipocalin/matrix metalloproteinase‐9 (NGAL•MMP‐9) complex in the inflammatory response to infection in pregnancies complicated by preterm birth. American Journal Of Reproductive Immunology 2016, 76: 108-117. PMID: 27251223, PMCID: PMC4942349, DOI: 10.1111/aji.12523.Peer-Reviewed Original ResearchConceptsIntra-amniotic infection/inflammationNeutrophil gelatinase-associated lipocalinMatrix metalloproteinase-9Preterm birthNGAL mRNA expressionGelatinase-associated lipocalinNormal pregnancy outcomeAmniotic fluid levelsInfection/inflammationPlacental villous trophoblastNGAL levelsPregnancy outcomesInflammatory conditionsInflammatory responseMetalloproteinase-9Villous trophoblastFluid levelsInnate immunityCollagenolytic effectMRNA expressionGelatinolytic activityPregnancyHost-microbe interactionsQRT-PCRAmniochorion
2011
Accreta complicating complete placenta previa is characterized by reduced systemic levels of vascular endothelial growth factor and by epithelial-to-mesenchymal transition of the invasive trophoblast
Wehrum MJ, Buhimschi IA, Salafia C, Thung S, Bahtiyar MO, Werner EF, Campbell KH, Laky C, Sfakianaki AK, Zhao G, Funai EF, Buhimschi CS. Accreta complicating complete placenta previa is characterized by reduced systemic levels of vascular endothelial growth factor and by epithelial-to-mesenchymal transition of the invasive trophoblast. American Journal Of Obstetrics And Gynecology 2011, 204: 411.e1-411.e11. PMID: 21316642, PMCID: PMC3136625, DOI: 10.1016/j.ajog.2010.12.027.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorComplete placenta previaPlacenta previaEndothelial growth factorCytokeratin 7Growth factorExtravillous trophoblastsSystemic vascular endothelial growth factorMesenchymal transitionFree vascular endothelial growth factorInterstitial extravillous trophoblastsMesenchymal transition featuresPlacental growth factorAngiogenic factor profilesExpression of vimentinInvasive extravillous trophoblastsUncomplicated pregnanciesMyometrial invasionPregnant womenPreviaInvasive trophoblastFactor profileHistological specimensInvasive placentationSerum samples