2018
Tenascin-X in amniotic fluid and reproductive tissues of pregnancies complicated by infection and preterm prelabor rupture of membranes†
Rood KM, Buhimschi CS, Zhao G, Oliver EA, Summerfield T, Bahtiyar MO, Buhimschi IA. Tenascin-X in amniotic fluid and reproductive tissues of pregnancies complicated by infection and preterm prelabor rupture of membranes†. Biology Of Reproduction 2018, 100: 773-782. PMID: 30277495, PMCID: PMC6437262, DOI: 10.1093/biolre/ioy216.Peer-Reviewed Original ResearchConceptsIntra-amniotic infection/inflammationPreterm prelabor ruptureFetal membranesAmniotic fluidTNX expressionPrelabor ruptureInfection/inflammationLung maturity testingMembrane statusSpontaneous PPROMPregnancy complicationsNormal outcomeTherapeutic targetGenetic karyotypingReproductive tissuesPPROMMRNA expressionMaturity testingPregnancyWestern blottingMRNA levelsQRT-PCRExtracellular matrix proteinsCervixInflammation
2016
Evidence for participation of neutrophil gelatinase‐associated lipocalin/matrix metalloproteinase‐9 (NGAL•MMP‐9) complex in the inflammatory response to infection in pregnancies complicated by preterm birth
Rood KM, Buhimschi IA, Rodewald Millen K, Bahtiyar MO, Thung S, Summerfield T, Zhao G, Ackerman W, Shellhaas C, Samuels P, Buhimschi CS. Evidence for participation of neutrophil gelatinase‐associated lipocalin/matrix metalloproteinase‐9 (NGAL•MMP‐9) complex in the inflammatory response to infection in pregnancies complicated by preterm birth. American Journal Of Reproductive Immunology 2016, 76: 108-117. PMID: 27251223, PMCID: PMC4942349, DOI: 10.1111/aji.12523.Peer-Reviewed Original ResearchConceptsIntra-amniotic infection/inflammationNeutrophil gelatinase-associated lipocalinMatrix metalloproteinase-9Preterm birthNGAL mRNA expressionGelatinase-associated lipocalinNormal pregnancy outcomeAmniotic fluid levelsInfection/inflammationPlacental villous trophoblastNGAL levelsPregnancy outcomesInflammatory conditionsInflammatory responseMetalloproteinase-9Villous trophoblastFluid levelsInnate immunityCollagenolytic effectMRNA expressionGelatinolytic activityPregnancyHost-microbe interactionsQRT-PCRAmniochorion