2016
Evidence for participation of neutrophil gelatinase‐associated lipocalin/matrix metalloproteinase‐9 (NGAL•MMP‐9) complex in the inflammatory response to infection in pregnancies complicated by preterm birth
Rood KM, Buhimschi IA, Rodewald Millen K, Bahtiyar MO, Thung S, Summerfield T, Zhao G, Ackerman W, Shellhaas C, Samuels P, Buhimschi CS. Evidence for participation of neutrophil gelatinase‐associated lipocalin/matrix metalloproteinase‐9 (NGAL•MMP‐9) complex in the inflammatory response to infection in pregnancies complicated by preterm birth. American Journal Of Reproductive Immunology 2016, 76: 108-117. PMID: 27251223, PMCID: PMC4942349, DOI: 10.1111/aji.12523.Peer-Reviewed Original ResearchConceptsIntra-amniotic infection/inflammationNeutrophil gelatinase-associated lipocalinMatrix metalloproteinase-9Preterm birthNGAL mRNA expressionGelatinase-associated lipocalinNormal pregnancy outcomeAmniotic fluid levelsInfection/inflammationPlacental villous trophoblastNGAL levelsPregnancy outcomesInflammatory conditionsInflammatory responseMetalloproteinase-9Villous trophoblastFluid levelsInnate immunityCollagenolytic effectMRNA expressionGelatinolytic activityPregnancyHost-microbe interactionsQRT-PCRAmniochorion
2015
Amniotic Fluid Soluble Myeloid Differentiation‐2 (sMD‐2) as Regulator of Intra‐amniotic Inflammation in Infection‐induced Preterm Birth
Dulay AT, Buhimschi CS, Zhao G, Oliver EA, Abdel-Razeq SS, Shook LL, Bahtiyar MO, Buhimschi IA. Amniotic Fluid Soluble Myeloid Differentiation‐2 (sMD‐2) as Regulator of Intra‐amniotic Inflammation in Infection‐induced Preterm Birth. American Journal Of Reproductive Immunology 2015, 73: 507-521. PMID: 25605324, PMCID: PMC4430418, DOI: 10.1111/aji.12362.Peer-Reviewed Original ResearchConceptsMyeloid differentiation 2Preterm birthSMD-2Fetal membranesInflammation-induced preterm birthHuman AFIntra-amniotic inflammatory responseInfection-induced preterm birthIntra-amniotic inflammationIL-6 levelsNormal pregnancy outcomeDifferentiation 2MD-2 mRNATime-dependent fashionPregnancy outcomesImmunohistochemistry findingsTLR4 ligandInflammatory cytokinesInflammatory responseHost responseMRNA expressionLevel of expressionWestern blottingHistological localizationAF samples
2012
48: Amniotic fluid (AF) soluble myeloid differentiation (MD)-2 factor as regulator of intraamniotic inflammation in infection-induced preterm birth
Dulay A, Buhimschi C, Zhao G, Lee S, Abdel-Razeq S, Bahtiyar M, Buhimschi I. 48: Amniotic fluid (AF) soluble myeloid differentiation (MD)-2 factor as regulator of intraamniotic inflammation in infection-induced preterm birth. American Journal Of Obstetrics And Gynecology 2012, 206: s31-s32. DOI: 10.1016/j.ajog.2011.10.074.Peer-Reviewed Original Research
2011
IL-6 Trans-Signaling System in Intra-Amniotic Inflammation, Preterm Birth, and Preterm Premature Rupture of the Membranes
Lee SY, Buhimschi IA, Dulay AT, Ali UA, Zhao G, Abdel-Razeq SS, Bahtiyar MO, Thung SF, Funai EF, Buhimschi CS. IL-6 Trans-Signaling System in Intra-Amniotic Inflammation, Preterm Birth, and Preterm Premature Rupture of the Membranes. The Journal Of Immunology 2011, 186: 3226-3236. PMID: 21282511, PMCID: PMC3800180, DOI: 10.4049/jimmunol.1003587.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniocentesisAmniotic FluidCytokine Receptor gp130FemaleFetal Membranes, Premature RuptureHumansInfant, NewbornInfant, PrematureInflammation MediatorsInterleukin-6Matrix Metalloproteinase 9Matrix Metalloproteinase InhibitorsPregnancyPregnancy ComplicationsPremature BirthReceptors, Interleukin-6Signal TransductionYoung AdultConceptsIntra-amniotic inflammationSIL-6RIL-6RPremature ruptureIL-6Classic IL-6 signalingAF IL-6RT-PCRPreterm premature ruptureIL-6 signalingMatrix metalloprotease-9Real-time RT-PCRActivation of cellsPhysiologic constituentPreterm laborPreterm birthIL-6 TransGestational ageThird trimesterInflammatory cellsSecond trimesterNormal gestationMetalloprotease-9IL-6 bindsFetal membranes
2009
Fetal renal artery impedance as assessed by Doppler ultrasound in pregnancies complicated by intraamniotic inflammation and preterm birth
Azpurua H, Dulay AT, Buhimschi IA, Bahtiyar MO, Funai E, Abdel-Razeq SS, Luo G, Bhandari V, Copel JA, Buhimschi CS. Fetal renal artery impedance as assessed by Doppler ultrasound in pregnancies complicated by intraamniotic inflammation and preterm birth. American Journal Of Obstetrics And Gynecology 2009, 200: 203.e1-203.e11. PMID: 19185102, PMCID: PMC3791328, DOI: 10.1016/j.ajog.2008.11.001.Peer-Reviewed Original ResearchConceptsCord blood IL-6End-diastolic blood flowRenal artery pulsatility indexArtery pulsatility indexBlood IL-6Amniotic fluid indexIntraamniotic inflammationResistance indexPulsatility indexPreterm birthIL-6Blood flowSerum blood urea nitrogen levelAF IL-6 levelsInflammation-associated preterm birthRenal artery resistance indexSystolic/diastolic ratioBlood urea nitrogen levelsAge-reference rangeCord blood interleukinRenal vascular bedIL-6 levelsHours of lifeUrea nitrogen levelsBlood interleukin
2008
Fetal Heart Rate Monitoring Patterns in Women with Amniotic Fluid Proteomic Profiles Indicative of Inflammation
Buhimschi C, Abdel-Razeq S, Cackovic M, Pettker C, Dulay A, Bahtiyar M, Zambrano E, Martin R, Norwitz E, Bhandari V, Buhimschi I. Fetal Heart Rate Monitoring Patterns in Women with Amniotic Fluid Proteomic Profiles Indicative of Inflammation. American Journal Of Perinatology 2008, 25: 359-372. PMID: 18512201, PMCID: PMC2724874, DOI: 10.1055/s-2008-1078761.Peer-Reviewed Original ResearchConceptsEarly-onset neonatal sepsisIntra-amniotic inflammationFetal heart rate monitoring patternsHistological chorioamnionitisPreterm birthPredictive valueAcute histological chorioamnionitisFetuses of womenHuman Development criteriaUseful clinical indicatorNegative predictive valuePositive predictive valueMonitoring patternsNeonatal sepsisPremature neonatesGestational ageLaboratory criteriaAntibiotic treatmentClinical indicatorsChild healthSensitive predictorInflammationAdmissionNeonatesInitial evaluationNucleated red blood cells are a direct response to mediators of inflammation in newborns with early-onset neonatal sepsis
Dulay AT, Buhimschi IA, Zhao G, Luo G, Abdel-Razeq S, Cackovic M, Rosenberg VA, Pettker CM, Thung SF, Bahtiyar MO, Bhandari V, Buhimschi CS. Nucleated red blood cells are a direct response to mediators of inflammation in newborns with early-onset neonatal sepsis. American Journal Of Obstetrics And Gynecology 2008, 198: 426.e1-426.e9. PMID: 18395034, PMCID: PMC4023236, DOI: 10.1016/j.ajog.2008.01.040.Peer-Reviewed Original ResearchConceptsEarly-onset neonatal sepsisNucleated red blood cellsInflammation-associated preterm birthNRBC countAcid-base statusIntraamniotic inflammationHistological chorioamnionitisNeonatal sepsisRed blood cellsPreterm birthGestational ageCord blood IL-6 levelsBlood IL-6 levelsFetal acid-base statusBlood cellsAbsolute NRBC countsIL-6 levelsEarly neonatal periodIntrauterine growth restrictionHours of birthEarlier gestational ageMediators of inflammationMinutes of deliveryAbsence of hypoxiaPreterm singletonsFetal Adrenal Gland Volume and Cortisol/Dehydroepiandrosterone Sulfate Ratio in Inflammation-Associated Preterm Birth
Buhimschi CS, Turan OM, Funai EF, Azpurua H, Bahtiyar MO, Turan S, Zhao G, Dulay A, Bhandari V, Copel JA, Buhimschi IA. Fetal Adrenal Gland Volume and Cortisol/Dehydroepiandrosterone Sulfate Ratio in Inflammation-Associated Preterm Birth. Obstetrics And Gynecology 2008, 111: 715-722. PMID: 18310376, DOI: 10.1097/aog.0b013e3181610294.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal GlandsAdultAmniotic FluidBiomarkersChorioamnionitisDehydroepiandrosterone SulfateFemaleFetal BloodHumansHydrocortisoneInfant, NewbornInfant, PrematureInterleukin-6Organ SizePituitary-Adrenal SystemPregnancyPremature BirthSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationUltrasonography, PrenatalConceptsAdrenal gland volumeFetal adrenal gland volumeIntraamniotic inflammationGland volumeInterleukin-6Preterm birthCord blood IL-6 levelsBlood IL-6 levelsCord blood IL-6Blood IL-6IL-6 levelsCortisol/Dehydroepiandrosterone Sulfate RatioPituitary-adrenocortical systemConsecutive singleton fetusesThree-dimensional ultrasonographyAdrenal volumeFetal adaptationGestational ageSteroid exposureFetal cortisolFetal weightSingleton fetusesUterine contractionsAdrenocortical axisDHEA ratioMultidimensional System Biology: Genetic Markers and Proteomic Biomarkers of Adverse Pregnancy Outcome in Preterm Birth
Buhimschi C, Rosenberg V, Dulay A, Thung S, Sfakianaki A, Bahtiyar M, Buhimschi I. Multidimensional System Biology: Genetic Markers and Proteomic Biomarkers of Adverse Pregnancy Outcome in Preterm Birth. American Journal Of Perinatology 2008, 25: 175-187. PMID: 18425720, DOI: 10.1055/s-2008-1061497.Peer-Reviewed Original ResearchConceptsPreterm birthSignificant public health problemMost preterm birthsAdverse pregnancy outcomesWeeks of gestationPublic health problemVariety of interventionsNeonatal outcomesPregnancy outcomesDecidual hemorrhagePremature infantsPremature birthLikely multifactorialPathophysiological pathwaysHealth problemsPathophysiological conditionsProteomic biomarkersOxidative stressBirthExcessive stretchingOutcomesHemorrhageGestationInfantsEtiologySingle Nucleotide Polymorphisms in the Human Progesterone Receptor Gene and Spontaneous Preterm Birth
Guoyang Luo, Morgan T, Bahtiyar MO, Snegovskikh VV, Schatz F, Kuczynski E, Funai EF, Dulay AT, Huang ST, Buhimschi CS, Buhimschi IA, Fortunato SJ, Menon R, Lockwood CJ, Norwitz ER. Single Nucleotide Polymorphisms in the Human Progesterone Receptor Gene and Spontaneous Preterm Birth. Reproductive Sciences 2008, 15: 147-155. PMID: 18276950, DOI: 10.1177/1933719107310990.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPreterm birthMaternal carriageSingle nucleotide polymorphismsProgesterone receptorPrior preterm birthHigh-risk womenBody mass indexRoute of deliveryLogistic regression analysisProgesterone receptor geneNeonatal outcomesConsecutive patientsProgesterone supplementationMass indexMaternal ageNucleotide polymorphismsMultivariate analysisT alleleHuman progesterone receptor geneTerm controlsMinor alleleProgesterone bindsBirthReceptor gene
2007
705: Maternal carriage of the K121Q single nucleotide polymorphism (SNP) in the ENPP (PC-1) gene is associated with preterm birth and diminished birthweight in a hispanic population
Norwitz E, Snegovskikh V, Lockwood C, Kuczynski E, Muglia L, Tilden D, Kozel B, Funai E, Bahtiyar M, Luo G, Thung S, Morgan T. 705: Maternal carriage of the K121Q single nucleotide polymorphism (SNP) in the ENPP (PC-1) gene is associated with preterm birth and diminished birthweight in a hispanic population. American Journal Of Obstetrics And Gynecology 2007, 197: s201. DOI: 10.1016/j.ajog.2007.10.733.Peer-Reviewed Original ResearchProteomic Profiling of the Amniotic Fluid to Detect Inflammation, Infection, and Neonatal Sepsis
Buhimschi CS, Bhandari V, Hamar BD, Bahtiyar MO, Zhao G, Sfakianaki AK, Pettker CM, Magloire L, Funai E, Norwitz ER, Paidas M, Copel JA, Weiner CP, Lockwood CJ, Buhimschi IA. Proteomic Profiling of the Amniotic Fluid to Detect Inflammation, Infection, and Neonatal Sepsis. PLOS Medicine 2007, 4: e18. PMID: 17227133, PMCID: PMC1769412, DOI: 10.1371/journal.pmed.0040018.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmniocentesisAmniotic FluidBiomarkersFemaleHumansInflammationMiddle AgedPregnancyPregnancy Complications, InfectiousPregnancy OutcomeProteomeProteomicsReproducibility of ResultsSensitivity and SpecificitySepsisSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationConceptsEarly-onset neonatal sepsisAmniotic fluid inflammationIntra-amniotic infectionMR scoreNeonatal sepsisAmniotic fluidHistological chorioamnionitisDelivery intervalNewborn Special Care UnitGram stainEarly-onset sepsisIntra-amniotic inflammationDegree of inflammationSpecial care unitsIntrauterine inflammationPlacental inflammationShorter amniocentesisPreterm deliveryPreterm laborSingleton pregnanciesConsecutive womenPreterm birthCare unitGestational agePremature rupture
2004
Defining standards of care in maternal-fetal medicine
Norwitz ER, Bahtiyar MO, Sibai BM. Defining standards of care in maternal-fetal medicine. American Journal Of Obstetrics And Gynecology 2004, 191: 1491-1496. PMID: 15507989, DOI: 10.1016/j.ajog.2004.06.043.Peer-Reviewed Original ResearchConceptsMaternal-fetal medicineCurrent practice patternsStandard of carePractice patternsMagnesium sulfate seizure prophylaxisMaternal-fetal medicine specialistsObstetric care providersPreterm premature ruptureContemporary practice patternsUniversity-based settingCervical cerclageSeizure prophylaxisTocolytic therapyHELLP syndromePreterm birthObstetric treatmentProgesterone supplementationPremature ruptureObstetric medicineCare providersMedicine specialistsControversial topicSpecialty trainingTherapyControversial areas