2019
9: Randomized controlled trial of n-acetylcysteine to prevent adverse neonatal outcome in pregnancies with intra-amniotic infection/inflammation
Buhimschi C, Bahtiyar M, Abdelghany O, Schneider L, Abdel-Raqez S, Dulay A, Lipkind H, Lopez E, Zhao G, Rogers L, Bhandari V, Buhimschi I. 9: Randomized controlled trial of n-acetylcysteine to prevent adverse neonatal outcome in pregnancies with intra-amniotic infection/inflammation. American Journal Of Obstetrics And Gynecology 2019, 220: s9. DOI: 10.1016/j.ajog.2018.11.011.Peer-Reviewed Original Research
2018
Tenascin-X in amniotic fluid and reproductive tissues of pregnancies complicated by infection and preterm prelabor rupture of membranes†
Rood KM, Buhimschi CS, Zhao G, Oliver EA, Summerfield T, Bahtiyar MO, Buhimschi IA. Tenascin-X in amniotic fluid and reproductive tissues of pregnancies complicated by infection and preterm prelabor rupture of membranes†. Biology Of Reproduction 2018, 100: 773-782. PMID: 30277495, PMCID: PMC6437262, DOI: 10.1093/biolre/ioy216.Peer-Reviewed Original ResearchConceptsIntra-amniotic infection/inflammationPreterm prelabor ruptureFetal membranesAmniotic fluidTNX expressionPrelabor ruptureInfection/inflammationLung maturity testingMembrane statusSpontaneous PPROMPregnancy complicationsNormal outcomeTherapeutic targetGenetic karyotypingReproductive tissuesPPROMMRNA expressionMaturity testingPregnancyWestern blottingMRNA levelsQRT-PCRExtracellular matrix proteinsCervixInflammation
2015
417: Neonates exposed to inflammation in-utero carry a spectrum of potent inflammatory and oxidant circulating molecules, that can be potentially reversed by N-acetylcysteine (NAC) and ethylpyruvate (EP)
Buhimschi I, Li M, Zhao G, Bahtiyar M, Cackovic M, Madri J, Bhandari V, Buhimschi C. 417: Neonates exposed to inflammation in-utero carry a spectrum of potent inflammatory and oxidant circulating molecules, that can be potentially reversed by N-acetylcysteine (NAC) and ethylpyruvate (EP). American Journal Of Obstetrics And Gynecology 2015, 212: s217. DOI: 10.1016/j.ajog.2014.10.463.Peer-Reviewed Original Research
2012
48: Amniotic fluid (AF) soluble myeloid differentiation (MD)-2 factor as regulator of intraamniotic inflammation in infection-induced preterm birth
Dulay A, Buhimschi C, Zhao G, Lee S, Abdel-Razeq S, Bahtiyar M, Buhimschi I. 48: Amniotic fluid (AF) soluble myeloid differentiation (MD)-2 factor as regulator of intraamniotic inflammation in infection-induced preterm birth. American Journal Of Obstetrics And Gynecology 2012, 206: s31-s32. DOI: 10.1016/j.ajog.2011.10.074.Peer-Reviewed Original Research
2009
527: Interleukin-6 trans-signaling molecules soluble GP130 and soluble IL-6 receptor in the amniotic fluid (AF) of women with intra-amniotic inflammation (IAI) and preterm premature rupture of membranes (PPROM)
Lee S, Buhimschi I, Zhao G, Dulay A, Bahtiyar M, Han C, Buhimschi C. 527: Interleukin-6 trans-signaling molecules soluble GP130 and soluble IL-6 receptor in the amniotic fluid (AF) of women with intra-amniotic inflammation (IAI) and preterm premature rupture of membranes (PPROM). American Journal Of Obstetrics And Gynecology 2009, 201: s196. DOI: 10.1016/j.ajog.2009.10.693.Peer-Reviewed Original Research
2008
Fetal Heart Rate Monitoring Patterns in Women with Amniotic Fluid Proteomic Profiles Indicative of Inflammation
Buhimschi C, Abdel-Razeq S, Cackovic M, Pettker C, Dulay A, Bahtiyar M, Zambrano E, Martin R, Norwitz E, Bhandari V, Buhimschi I. Fetal Heart Rate Monitoring Patterns in Women with Amniotic Fluid Proteomic Profiles Indicative of Inflammation. American Journal Of Perinatology 2008, 25: 359-372. PMID: 18512201, PMCID: PMC2724874, DOI: 10.1055/s-2008-1078761.Peer-Reviewed Original ResearchConceptsEarly-onset neonatal sepsisIntra-amniotic inflammationFetal heart rate monitoring patternsHistological chorioamnionitisPreterm birthPredictive valueAcute histological chorioamnionitisFetuses of womenHuman Development criteriaUseful clinical indicatorNegative predictive valuePositive predictive valueMonitoring patternsNeonatal sepsisPremature neonatesGestational ageLaboratory criteriaAntibiotic treatmentClinical indicatorsChild healthSensitive predictorInflammationAdmissionNeonatesInitial evaluationUsing Proteomic Analysis of the Human Amniotic Fluid to Identify Histologic Chorioamnionitis
Buhimschi IA, Zambrano E, Pettker CM, Bahtiyar MO, Paidas M, Rosenberg VA, Thung S, Salafia CM, Buhimschi CS. Using Proteomic Analysis of the Human Amniotic Fluid to Identify Histologic Chorioamnionitis. Obstetrics And Gynecology 2008, 111: 403-412. PMID: 18238979, DOI: 10.1097/aog.0b013e31816102aa.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmniocentesisAmniotic FluidBiomarkersBlack or African AmericanChorioamnionitisFemaleHumansInflammationPregnancyPregnancy Complications, InfectiousPregnancy OutcomePrevalenceProteomeProteomicsReproducibility of ResultsSensitivity and SpecificitySeverity of Illness IndexSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationWhite PeopleConceptsHistologic chorioamnionitisAmniotic fluidIntra-amniotic inflammationGrade of inflammationAbsence of biomarkersHuman amniotic fluidSurface-enhanced laser desorption ionization timeAfrican American womenPreterm laborSingleton pregnanciesDelivery intervalPlacental pathologyGestational agePremature ruptureSevere inflammationEarly recognitionChorioamnionitisChorionic plateInflammationTherapeutic interventionsProteomic biomarkersCalgranulin CBiomarkersProteomic analysisScores
2007
50: Nucleated red blood cells (NRBC) are a direct response to mediators of inflammation in newborns with early onset neonatal sepsis (EONS)
Dulay A, buhimschi I, Zhao G, Luo G, Abdel-Razeq S, Cackovic M, Rosenberg V, Pettker C, Thung S, Bahtiyar M, Bhandari V, Buhimschi C. 50: Nucleated red blood cells (NRBC) are a direct response to mediators of inflammation in newborns with early onset neonatal sepsis (EONS). American Journal Of Obstetrics And Gynecology 2007, 197: s22. DOI: 10.1016/j.ajog.2007.10.056.Peer-Reviewed Original Research
2006
Fetal heart rate monitoring patterns (FHR-MP) to predict early-onset neonatal sepsis in utero in pregnancies complicated by intra-amniotic infection/inflammation
Buhimschi C, Abdel-Razeq S, Pettker C, Cackovic M, Bahtiyar M, Norwitz E, Bhandari V, Buhimschi I. Fetal heart rate monitoring patterns (FHR-MP) to predict early-onset neonatal sepsis in utero in pregnancies complicated by intra-amniotic infection/inflammation. American Journal Of Obstetrics And Gynecology 2006, 195: s224. DOI: 10.1016/j.ajog.2006.10.814.Peer-Reviewed Original Research