2011
Accreta complicating complete placenta previa is characterized by reduced systemic levels of vascular endothelial growth factor and by epithelial-to-mesenchymal transition of the invasive trophoblast
Wehrum MJ, Buhimschi IA, Salafia C, Thung S, Bahtiyar MO, Werner EF, Campbell KH, Laky C, Sfakianaki AK, Zhao G, Funai EF, Buhimschi CS. Accreta complicating complete placenta previa is characterized by reduced systemic levels of vascular endothelial growth factor and by epithelial-to-mesenchymal transition of the invasive trophoblast. American Journal Of Obstetrics And Gynecology 2011, 204: 411.e1-411.e11. PMID: 21316642, PMCID: PMC3136625, DOI: 10.1016/j.ajog.2010.12.027.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorComplete placenta previaPlacenta previaEndothelial growth factorCytokeratin 7Growth factorExtravillous trophoblastsSystemic vascular endothelial growth factorMesenchymal transitionFree vascular endothelial growth factorInterstitial extravillous trophoblastsMesenchymal transition featuresPlacental growth factorAngiogenic factor profilesExpression of vimentinInvasive extravillous trophoblastsUncomplicated pregnanciesMyometrial invasionPregnant womenPreviaInvasive trophoblastFactor profileHistological specimensInvasive placentationSerum samples
2008
Relationships of maternal serum levels of vascular endothelial growth factor and tensile strength properties of the cervix in a rat model of chronic hypoxia
Sfakianaki AK, Buhimschi IA, Ravishankar V, Bahtiyar MO, Dulay AT, Buhimschi CS. Relationships of maternal serum levels of vascular endothelial growth factor and tensile strength properties of the cervix in a rat model of chronic hypoxia. American Journal Of Obstetrics And Gynecology 2008, 198: 223.e1-223.e7. PMID: 18226631, DOI: 10.1016/j.ajog.2007.09.054.Peer-Reviewed Original ResearchConceptsMaternal serum levelsVascular endothelial growth factorSerum levelsSignificant inverse correlationChronic hypoxiaEndothelial growth factorMaternal serum vascular endothelial growth factorSerum vascular endothelial growth factorAdult Sprague-Dawley ratsGrowth factorFree serum levelsInverse correlationRat uterine cervixSprague-Dawley ratsGroups of animalsHPx groupNonpregnant controlsUterine cervixHypoxic chamberRat modelMaternal bloodCervical stiffnessCervixCervical strengthDay 21
2007
426: Relationships of maternal serum levels of vascular endothelial growth factor (VEGF) and tensile properties of the cervix in a rat model of chronic hypoxia
Sfakianaki A, Buhimschi I, Ravishankar V, Bahtiyar M, Dulay A, Buhimschi C. 426: Relationships of maternal serum levels of vascular endothelial growth factor (VEGF) and tensile properties of the cervix in a rat model of chronic hypoxia. American Journal Of Obstetrics And Gynecology 2007, 197: s127. DOI: 10.1016/j.ajog.2007.10.445.Peer-Reviewed Original ResearchContrasting effects of chronic hypoxia and nitric oxide synthase inhibition on circulating angiogenic factors in a rat model of growth restriction
Bahtiyar MO, Buhimschi C, Ravishankar V, Copel J, Norwitz E, Julien S, Guller S, Buhimschi IA. Contrasting effects of chronic hypoxia and nitric oxide synthase inhibition on circulating angiogenic factors in a rat model of growth restriction. American Journal Of Obstetrics And Gynecology 2007, 196: 72.e1-72.e6. PMID: 17240241, DOI: 10.1016/j.ajog.2006.07.048.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChronic DiseaseDisease Models, AnimalEnzyme InhibitorsFemaleFetal Growth RetardationHypoxiaNG-Nitroarginine Methyl EsterNitric Oxide SynthasePlacenta Growth FactorPregnancyPregnancy ProteinsRatsRats, Sprague-DawleyVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth FactorsConceptsVascular endothelial growth factorL-NAMESerum levelsChronic hypoxiaSoluble fms-like tyrosine kinase-1Nitro-L-arginine methyl esterFms-like tyrosine kinase-1Adult Sprague-Dawley ratsGrowth factorMaternal serum levelsFree serum levelsIntrauterine growth restrictionOnset of laborPlacental growth factorTyrosine kinase-1Subcutaneous osmotic pumpsSprague-Dawley ratsNitric oxide inhibitionEndothelial growth factorNonpregnant controlsSFlt-1Growth restrictionHypoxic chamberMaternal bloodOxide inhibition