Multidimensional System Biology: Genetic Markers and Proteomic Biomarkers of Adverse Pregnancy Outcome in Preterm Birth
Buhimschi C, Rosenberg V, Dulay A, Thung S, Sfakianaki A, Bahtiyar M, Buhimschi I. Multidimensional System Biology: Genetic Markers and Proteomic Biomarkers of Adverse Pregnancy Outcome in Preterm Birth. American Journal Of Perinatology 2008, 25: 175-187. PMID: 18425720, DOI: 10.1055/s-2008-1061497.Peer-Reviewed Original ResearchConceptsPreterm birthSignificant public health problemMost preterm birthsAdverse pregnancy outcomesWeeks of gestationPublic health problemVariety of interventionsNeonatal outcomesPregnancy outcomesDecidual hemorrhagePremature infantsPremature birthLikely multifactorialPathophysiological pathwaysHealth problemsPathophysiological conditionsProteomic biomarkersOxidative stressBirthExcessive stretchingOutcomesHemorrhageGestationInfantsEtiologySingle Nucleotide Polymorphisms in the Human Progesterone Receptor Gene and Spontaneous Preterm Birth
Guoyang Luo, Morgan T, Bahtiyar MO, Snegovskikh VV, Schatz F, Kuczynski E, Funai EF, Dulay AT, Huang ST, Buhimschi CS, Buhimschi IA, Fortunato SJ, Menon R, Lockwood CJ, Norwitz ER. Single Nucleotide Polymorphisms in the Human Progesterone Receptor Gene and Spontaneous Preterm Birth. Reproductive Sciences 2008, 15: 147-155. PMID: 18276950, DOI: 10.1177/1933719107310990.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPreterm birthMaternal carriageSingle nucleotide polymorphismsProgesterone receptorPrior preterm birthHigh-risk womenBody mass indexRoute of deliveryLogistic regression analysisProgesterone receptor geneNeonatal outcomesConsecutive patientsProgesterone supplementationMass indexMaternal ageNucleotide polymorphismsMultivariate analysisT alleleHuman progesterone receptor geneTerm controlsMinor alleleProgesterone bindsBirthReceptor gene