2023
Adaptation of Nontypeable Haemophilus influenzae in Human Airways in COPD: Genome Rearrangements and Modulation of Expression of HMW1 and HMW2
Murphy T, Kirkham C, D’Mello A, Sethi S, Pettigrew M, Tettelin H. Adaptation of Nontypeable Haemophilus influenzae in Human Airways in COPD: Genome Rearrangements and Modulation of Expression of HMW1 and HMW2. MBio 2023, 14: e00140-23. PMID: 36927061, PMCID: PMC10127715, DOI: 10.1128/mbio.00140-23.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseNontypeable Haemophilus influenzaeObstructive pulmonary diseaseRespiratory epithelial cellsHuman airwaysHaemophilus influenzaeAirway inflammationLung functionMechanisms of persistencePulmonary diseaseEpithelial cellsNovel interventionsChronic lower airway infectionsProgressive lossAirways of adultsLower airway infectionHuman respiratory epithelial cellsCommon debilitating disorderStrains of NTHiNTHi infectionAirway infectionLower airwaysCommon causeSequential isolatesSerial isolates
2018
Persistence of Moraxella catarrhalis in Chronic Obstructive Pulmonary Disease and Regulation of the Hag/MID Adhesin
Murphy TF, Brauer AL, Pettigrew MM, LaFontaine ER, Tettelin H. Persistence of Moraxella catarrhalis in Chronic Obstructive Pulmonary Disease and Regulation of the Hag/MID Adhesin. The Journal Of Infectious Diseases 2018, 219: 1448-1455. PMID: 30496439, PMCID: PMC6467191, DOI: 10.1093/infdis/jiy680.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseM. catarrhalisPulmonary diseaseMoraxella catarrhalisPersistent strainsDuration of persistenceHuman airwaysCatarrhalisCessation of expressionAirwayMajor pathogenPatientsBacterial pathogensDiseaseVirulence-associated phenotypesAdultsCollected strainsMost strainsExpressionHuman cellsPathogensPathogenesisPersistenceMonthsGastrointestinal Microbiota Disruption and Risk of Colonization With Carbapenem-resistant Pseudomonas aeruginosa in Intensive Care Unit Patients
Pettigrew MM, Gent JF, Kong Y, Halpin AL, Pineles L, Harris AD, Johnson JK. Gastrointestinal Microbiota Disruption and Risk of Colonization With Carbapenem-resistant Pseudomonas aeruginosa in Intensive Care Unit Patients. Clinical Infectious Diseases 2018, 69: 604-613. PMID: 30383203, PMCID: PMC6669284, DOI: 10.1093/cid/ciy936.Peer-Reviewed Original ResearchConceptsCarbapenem-resistant Pseudomonas aeruginosaIntensive care unit patientsCare unit patientsPiperacillin-tazobactamUnit patientsICU patientsMarker of riskMaryland Medical CenterRisk of colonizationRibosomal RNA gene sequencingRNA gene sequencingAdmission swabCRPA infectionPseudomonas aeruginosaICU admissionPatient characteristicsMicrobiota disruptionMedical CenterGastrointestinal tractAdditional swabsAntimicrobial exposureLower riskEvaluated associationsPatientsProtective roleHaemophilus influenzae genome evolution during persistence in the human airways in chronic obstructive pulmonary disease
Pettigrew MM, Ahearn CP, Gent JF, Kong Y, Gallo MC, Munro JB, D’Mello A, Sethi S, Tettelin H, Murphy TF. Haemophilus influenzae genome evolution during persistence in the human airways in chronic obstructive pulmonary disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: e3256-e3265. PMID: 29555745, PMCID: PMC5889651, DOI: 10.1073/pnas.1719654115.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseCandidate vaccine antigensHuman airwaysPulmonary diseaseVaccine antigensRespiratory tract pathogensHuman respiratory tractProspective studyTract pathogensNTHi isolatesRespiratory tractAnimal modelsVaccine developmentHuman infectionsAirwayNTHiSurface moleculesAmino acid sequence changesWhole-genome sequencingAntigenBacterial pathogensDiseaseSubset of strainsVirulence functions
2017
Risk Factors and Outcomes Associated with Multidrug-Resistant Acinetobacter baumannii upon Intensive Care Unit Admission
Blanco N, Harris AD, Rock C, Johnson JK, Pineles L, Bonomo RA, Srinivasan A, Pettigrew MM, Thom KA. Risk Factors and Outcomes Associated with Multidrug-Resistant Acinetobacter baumannii upon Intensive Care Unit Admission. Antimicrobial Agents And Chemotherapy 2017, 62: 10.1128/aac.01631-17. PMID: 29133567, PMCID: PMC5740370, DOI: 10.1128/aac.01631-17.Peer-Reviewed Original ResearchConceptsMedical intensive care unitSurgical intensive care unitIntensive care unitICU admissionRisk factorsCare unitIntensive care unit admissionBroad-spectrum antibiotic useMultidrug-resistant Acinetobacter baumanniiPositive clinical cultureCare unit admissionRetrospective cohort analysisAssociated risk factorsEmpirical antibiotic selectionInfection control practicesPrevalence of MDRMaryland Medical CenterPerirectal surveillance culturesImportant nosocomial pathogenUnit admissionAdult patientsICU typePrevious admissionsCurrent hospitalizationActive surveillance
2016
Pseudomonas aeruginosa Colonization in the Intensive Care Unit: Prevalence, Risk Factors, and Clinical Outcomes
Harris AD, Jackson SS, Robinson G, Pineles L, Leekha S, Thom KA, Wang Y, Doll M, Pettigrew MM, Johnson JK. Pseudomonas aeruginosa Colonization in the Intensive Care Unit: Prevalence, Risk Factors, and Clinical Outcomes. Infection Control And Hospital Epidemiology 2016, 37: 544-548. PMID: 26832307, PMCID: PMC4833506, DOI: 10.1017/ice.2015.346.Peer-Reviewed Original ResearchConceptsIntensive care unitPseudomonas aeruginosa colonizationRisk factorsICU admissionClinical culturesCurrent hospitalizationAeruginosa colonizationCare unitIntensive care unit admissionP. aeruginosaSurgical intensive care unitPositive clinical cultureCare unit admissionEmpirical antibiotic therapyTertiary care hospitalType of ICUSignificant risk factorsP. aeruginosa colonizationRapid diagnostic testingPerirectal surveillance culturesUnit admissionCohort studyAntibiotic therapyCare hospitalClinical outcomes
2015
Expression of IgA Proteases by Haemophilus influenzae in the Respiratory Tract of Adults With Chronic Obstructive Pulmonary Disease
Murphy TF, Kirkham C, Jones MM, Sethi S, Kong Y, Pettigrew MM. Expression of IgA Proteases by Haemophilus influenzae in the Respiratory Tract of Adults With Chronic Obstructive Pulmonary Disease. The Journal Of Infectious Diseases 2015, 212: 1798-1805. PMID: 25995193, PMCID: PMC4633762, DOI: 10.1093/infdis/jiv299.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseH. influenzaeIgA protease genePulmonary diseaseHuman airwaysHaemophilus influenzaeIgA proteaseH. influenzae infectionsHuman respiratory epithelial cellsHuman IgA1Respiratory epithelial cellsInfluenzae infectionRespiratory tractIgA protease activitySputum samplesClinical settingInfluenzaeEpithelial cellsInfectionAirwayIgA1 fragmentsDiseaseIgA1Protease gene
2014
Detection of livestock-associated methicillin-resistant Staphylococcus aureus among swine workers in Romania
Huang E, Gurzau AE, Hanson BM, Kates AE, Smith TC, Pettigrew MM, Spinu M, Rabinowitz PM. Detection of livestock-associated methicillin-resistant Staphylococcus aureus among swine workers in Romania. Journal Of Infection And Public Health 2014, 7: 323-332. PMID: 24821273, DOI: 10.1016/j.jiph.2014.03.008.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgricultureAnimal HusbandryAnimalsCarrier StateFemaleHumansLivestockMaleMethicillin-Resistant Staphylococcus aureusMiddle AgedMolecular TypingNasal MucosaOccupational ExposureOropharynxPrevalenceRomaniaStaphylococcal InfectionsStaphylococcal Protein ASurveys and QuestionnairesSwineConceptsLivestock-associated methicillin-resistant Staphylococcus aureusMethicillin-resistant Staphylococcus aureusLA-MRSASwine workersLivestock workersSpa type t034Commercial pig farmsCommunity-associated MRSA strainsPig farmsDevastating pathogenStaphylococcus aureusFarmsCommercial movementsSubstantial health risksMRSA carriersMRSA colonizationHigh morbidityRisk factorsMRSA strainsHealth statusBiosafety practicesCommunity contactsProduction facilitiesPathogensEpidemiology
2011
Multiple chlamydia infection among young women: comparing the role of individual- and neighbourhood-level measures of socioeconomic status
Biello KB, Pettigrew MM, Niccolai LM. Multiple chlamydia infection among young women: comparing the role of individual- and neighbourhood-level measures of socioeconomic status. Sexually Transmitted Infections 2011, 87: 560. PMID: 21940727, PMCID: PMC3438508, DOI: 10.1136/sextrans-2011-050185.Peer-Reviewed Original ResearchConceptsIndividual-level socioeconomic statusChlamydia diagnosisYoung womenSocioeconomic statusChlamydia infectionNeighborhood-level socioeconomic statusIndividual-level SESNeighborhood socioeconomic statusHigh burdenNeighborhood-level povertyMultiple infectionsSocioeconomic disparitiesDiagnosisNeighborhood-level measuresWomenInfectionHigh-poverty areasLow-poverty areasValid measureBurdenIndividual-level measuresStatusUseful measureIndividual-level variablesChlamydiaBehavioural sources of repeat Chlamydia trachomatis infections: importance of different sex partners
Niccolai LM, Livingston KA, Laufer AS, Pettigrew MM. Behavioural sources of repeat Chlamydia trachomatis infections: importance of different sex partners. Sexually Transmitted Infections 2011, 87: 248. PMID: 21212380, PMCID: PMC5438152, DOI: 10.1136/sti.2010.045484.Peer-Reviewed Original ResearchConceptsChlamydia trachomatis infectionRepeat infectionsNew sex partnerTrachomatis infectionSex partnersC. trachomatisRepeat Chlamydia trachomatis infectionsPopulation attributable risk percentageC. trachomatis infectionCumulative incidenceDifferent-sex partnersRisk percentageYounger ageInfectionBehavioral surveyBaselineDifferent genotypesTrachomatisWomenMolecular methodsGenotypesPatientsFollowIncidence
2009
Comparison of Sexual Partnership Characteristics and Associations with Inconsistent Condom Use among a Sample of Adolescents and Adult Women Diagnosed with Chlamydia trachomatis
Foulkes HB, Pettigrew MM, Livingston KA, Niccolai LM. Comparison of Sexual Partnership Characteristics and Associations with Inconsistent Condom Use among a Sample of Adolescents and Adult Women Diagnosed with Chlamydia trachomatis. Journal Of Women's Health 2009, 18: 393-399. PMID: 19245304, DOI: 10.1089/jwh.2008.0840.Peer-Reviewed Original ResearchConceptsInconsistent condom useCondom useSexual partnershipsPrevalent chlamydia infectionSexual partnership characteristicsPartner age differenceChlamydia infectionMain partnershipsChlamydia trachomatisAdult womenPrevention effortsSexual relationshipsAdolescent femalesPartnership durationFemale adolescentsPartnership characteristicsSample of adolescentsShort durationAdolescentsInfectionWomenDurationType of partner
2007
Behavioral intentions in sexual partnerships following a diagnosis of Chlamydia trachomatis
Niccolai LM, Livingston KA, Teng F, Pettigrew MM. Behavioral intentions in sexual partnerships following a diagnosis of Chlamydia trachomatis. Preventive Medicine 2007, 46: 170-176. PMID: 17936349, DOI: 10.1016/j.ypmed.2007.08.013.Peer-Reviewed Original Research
2003
Duration of Breastfeeding, Daycare, and Physician Visits among Infants 6 Months and Younger
Pettigrew MM, Khodaee M, Gillespie B, Schwartz K, Bobo JK, Foxman B. Duration of Breastfeeding, Daycare, and Physician Visits among Infants 6 Months and Younger. Annals Of Epidemiology 2003, 13: 431-435. PMID: 12875801, DOI: 10.1016/s1047-2797(02)00463-5.Peer-Reviewed Original ResearchConceptsDuration of breastfeedingAdditional childrenInfants 6 monthsHealth care providersFirstborn childrenPhysician visitsWeeks postpartumMonths postpartumBirthing centerCare providersBreastfeedingNumber of childrenAdditional weeksMailed questionnaireInfantsWomenChildrenPostpartumDurationVisitsMonthsDaycareSuburban DetroitIllnessWeeks