2018
Gastrointestinal Microbiota Disruption and Risk of Colonization With Carbapenem-resistant Pseudomonas aeruginosa in Intensive Care Unit Patients
Pettigrew MM, Gent JF, Kong Y, Halpin AL, Pineles L, Harris AD, Johnson JK. Gastrointestinal Microbiota Disruption and Risk of Colonization With Carbapenem-resistant Pseudomonas aeruginosa in Intensive Care Unit Patients. Clinical Infectious Diseases 2018, 69: 604-613. PMID: 30383203, PMCID: PMC6669284, DOI: 10.1093/cid/ciy936.Peer-Reviewed Original ResearchConceptsCarbapenem-resistant Pseudomonas aeruginosaIntensive care unit patientsCare unit patientsPiperacillin-tazobactamUnit patientsICU patientsMarker of riskMaryland Medical CenterRisk of colonizationRibosomal RNA gene sequencingRNA gene sequencingAdmission swabCRPA infectionPseudomonas aeruginosaICU admissionPatient characteristicsMicrobiota disruptionMedical CenterGastrointestinal tractAdditional swabsAntimicrobial exposureLower riskEvaluated associationsPatientsProtective role
2016
Density, Serotype Diversity, and Fitness of Streptococcus pneumoniae in Upper Respiratory Tract Cocolonization With Nontypeable Haemophilus influenzae
Lewnard JA, Huppert A, Givon-Lavi N, Pettigrew MM, Regev-Yochay G, Dagan R, Weinberger DM. Density, Serotype Diversity, and Fitness of Streptococcus pneumoniae in Upper Respiratory Tract Cocolonization With Nontypeable Haemophilus influenzae. The Journal Of Infectious Diseases 2016, 214: 1411-1420. PMID: 27540112, PMCID: PMC5079371, DOI: 10.1093/infdis/jiw381.Peer-Reviewed Original ResearchConceptsNontypeable Haemophilus influenzaeNTHi colonizationPneumococcal serotypesChildren 2Haemophilus influenzaeStreptococcus pneumoniaeUpper respiratory tract carriageSerotype diversityComplex otitis mediaNasopharyngeal pneumococcal carriagePneumococcal conjugate vaccineImmune-evasive phenotypePneumococcal serotype diversityNTHi carriageConjugate vaccinePneumococcal carriageOtitis mediaStudy visitNeutrophil resistanceCapsular thicknessLogistic regressionDensity associationsCarriageSerotypesColonization densityPseudomonas aeruginosa Colonization in the Intensive Care Unit: Prevalence, Risk Factors, and Clinical Outcomes
Harris AD, Jackson SS, Robinson G, Pineles L, Leekha S, Thom KA, Wang Y, Doll M, Pettigrew MM, Johnson JK. Pseudomonas aeruginosa Colonization in the Intensive Care Unit: Prevalence, Risk Factors, and Clinical Outcomes. Infection Control And Hospital Epidemiology 2016, 37: 544-548. PMID: 26832307, PMCID: PMC4833506, DOI: 10.1017/ice.2015.346.Peer-Reviewed Original ResearchConceptsIntensive care unitPseudomonas aeruginosa colonizationRisk factorsICU admissionClinical culturesCurrent hospitalizationAeruginosa colonizationCare unitIntensive care unit admissionP. aeruginosaSurgical intensive care unitPositive clinical cultureCare unit admissionEmpirical antibiotic therapyTertiary care hospitalType of ICUSignificant risk factorsP. aeruginosa colonizationRapid diagnostic testingPerirectal surveillance culturesUnit admissionCohort studyAntibiotic therapyCare hospitalClinical outcomes
2015
Epidemiological Markers for Interactions Among Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus in Upper Respiratory Tract Carriage
Lewnard JA, Givon-Lavi N, Huppert A, Pettigrew MM, Regev-Yochay G, Dagan R, Weinberger DM. Epidemiological Markers for Interactions Among Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus in Upper Respiratory Tract Carriage. The Journal Of Infectious Diseases 2015, 213: 1596-1605. PMID: 26704617, PMCID: PMC4837906, DOI: 10.1093/infdis/jiv761.Peer-Reviewed Original ResearchMeSH KeywordsCarrier StateChild, PreschoolFemaleHaemophilus InfectionsHaemophilus influenzaeHeptavalent Pneumococcal Conjugate VaccineHumansInfantIsraelLongitudinal StudiesMalePneumococcal InfectionsRespiratory Tract InfectionsRisk FactorsStaphylococcal InfectionsStaphylococcus aureusStreptococcus pneumoniaeVaccines, ConjugateConceptsPneumococcal serotype replacementH. influenzaeSerotype replacementS. pneumoniaeHaemophilus influenzaeStreptococcus pneumoniaePneumococcal conjugate vaccine trialUpper respiratory tract carriagePneumococcal vaccine introductionS. aureus carriageMonths of ageStaphylococcus aureusPCV7 recipientsAureus carriageVaccine introductionVaccine trialsCarriage patternsConfounding factorsClinical interventionsInfluenzaeEpidemiological markersBedouin childrenPneumoniaeCarriageS. aureus
2014
Detection of livestock-associated methicillin-resistant Staphylococcus aureus among swine workers in Romania
Huang E, Gurzau AE, Hanson BM, Kates AE, Smith TC, Pettigrew MM, Spinu M, Rabinowitz PM. Detection of livestock-associated methicillin-resistant Staphylococcus aureus among swine workers in Romania. Journal Of Infection And Public Health 2014, 7: 323-332. PMID: 24821273, DOI: 10.1016/j.jiph.2014.03.008.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgricultureAnimal HusbandryAnimalsCarrier StateFemaleHumansLivestockMaleMethicillin-Resistant Staphylococcus aureusMiddle AgedMolecular TypingNasal MucosaOccupational ExposureOropharynxPrevalenceRomaniaStaphylococcal InfectionsStaphylococcal Protein ASurveys and QuestionnairesSwineConceptsLivestock-associated methicillin-resistant Staphylococcus aureusMethicillin-resistant Staphylococcus aureusLA-MRSASwine workersLivestock workersSpa type t034Commercial pig farmsCommunity-associated MRSA strainsPig farmsDevastating pathogenStaphylococcus aureusFarmsCommercial movementsSubstantial health risksMRSA carriersMRSA colonizationHigh morbidityRisk factorsMRSA strainsHealth statusBiosafety practicesCommunity contactsProduction facilitiesPathogensEpidemiology
2006
Predictors for Haemophilus influenzae Colonization, Antibiotic Resistance and for Sharing an Identical Isolate Among Children Attending 16 Licensed Day-Care Centers in Michigan
Barbosa-Cesnik C, Farjo RS, Patel M, Gilsdorf J, McCoy SI, Pettigrew MM, Marrs C, Foxman B. Predictors for Haemophilus influenzae Colonization, Antibiotic Resistance and for Sharing an Identical Isolate Among Children Attending 16 Licensed Day-Care Centers in Michigan. The Pediatric Infectious Disease Journal 2006, 25: 219-223. PMID: 16511383, DOI: 10.1097/01.inf.0000202130.78540.28.Peer-Reviewed Original ResearchConceptsDay care centersH. influenzae colonizationNontypable H. influenzaeH. influenzaeOtitis mediaColonized childrenAntibiotic resistanceLicensed day care centersSame day care centerHaemophilus influenzae colonizationModifiable risk factorsRisk factor questionnaireH. influenzae isolatesNontypable Haemophilus influenzaeDay care center directorsIdentical isolatesInfluenzae isolatesPacifier useThroat swabsHygiene habitsRisk factorsTobacco smokeImportant causeHaemophilus influenzaeOverall colonization rate
2005
Genomic Subtraction Followed by Dot Blot Screening of Streptococcus pneumoniae Clinical and Carriage Isolates Identifies Genetic Differences Associated with Strains That Cause Otitis Media
Pettigrew MM, Fennie KP. Genomic Subtraction Followed by Dot Blot Screening of Streptococcus pneumoniae Clinical and Carriage Isolates Identifies Genetic Differences Associated with Strains That Cause Otitis Media. Infection And Immunity 2005, 73: 2805-2811. PMID: 15845484, PMCID: PMC1087362, DOI: 10.1128/iai.73.5.2805-2811.2005.Peer-Reviewed Original ResearchConceptsMiddle ear isolatesEar isolatesOtitis mediaMiddle earOtitis media pathogenesisCerebrospinal fluid isolatesBacterial otitis mediaStreptococcus pneumoniae strainsMolecular epidemiological approachSpecific bacterial factorsCarriage isolatesPneumoniae strainsBacterial factorsDot-blot screeningBloodBrucella melitensisEpidemiological approachMeningitisFurther studiesYoung childrenPrecise roleCarriageMedium virulenceIsolatesEar
2004
Diversity and sharing of Haemophilus influenzae strains colonizing healthy children attending day-care centers
FARJO RS, FOXMAN B, PATEL MJ, ZHANG L, PETTIGREW MM, MCCOY SI, MARRS CF, GILSDORF JR. Diversity and sharing of Haemophilus influenzae strains colonizing healthy children attending day-care centers. The Pediatric Infectious Disease Journal 2004, 23: 41-46. PMID: 14743045, DOI: 10.1097/01.inf.0000106981.89572.d1.Peer-Reviewed Original ResearchMeSH KeywordsCarrier StateChild Day Care CentersChild, PreschoolCohort StudiesColony Count, MicrobialDNA, BacterialElectrophoresis, Gel, Pulsed-FieldFemaleGenotypeHaemophilus InfectionsHaemophilus influenzaeHumansIncidenceMaleMass ScreeningMichiganOtitis MediaPolymerase Chain ReactionReference ValuesRisk AssessmentSerotypingConceptsDay care centersH. influenzaeHealthy childrenH. influenzae organismsAcute otitis mediaH. influenzae colonizationH. influenzae strainsUnique strainsEnterobacterial repetitive intergenic consensus PCRThroat culturesOtitis mediaInitial screening techniqueNasopharyngeal colonizationPrevalence ratesColonizing strainsHaemophilus influenzaeHeterogeneity of strainInfluenzaeConsensus PCRRate of colonizationChildrenField gel electrophoresisSame strainPathogenic microorganismsEvidence of sharing