Virulence of Streptococcus pneumoniae serotype 6C in experimental otitis media
Sabharwal V, Figueira M, Pelton SI, Pettigrew MM. Virulence of Streptococcus pneumoniae serotype 6C in experimental otitis media. Microbes And Infection 2012, 14: 712-718. PMID: 22414497, PMCID: PMC3382049, DOI: 10.1016/j.micinf.2012.02.008.Peer-Reviewed Original ResearchConceptsAcute otitis mediaExperimental otitis mediaPneumococcal conjugate vaccineOtitis mediaSerotype 6CInvasive pneumococcal diseaseOverall carriage rateLow-density infectionsMiddle ear infectionStreptococcus pneumoniae serotype 6CReplacement serotypesPneumococcal diseaseVaccine serotypesConjugate vaccineNonvaccine serotypesCarriage rateEar infectionsNasopharyngeal colonizationChinchilla modelStreptococcus pneumoniaeHost defenseSerotypesDisease potentialInfectionDisease