2015
Streptococcus pneumoniae biofilm formation and dispersion during colonization and disease
Chao Y, Marks LR, Pettigrew MM, Hakansson AP. Streptococcus pneumoniae biofilm formation and dispersion during colonization and disease. Frontiers In Cellular And Infection Microbiology 2015, 4: 194. PMID: 25629011, PMCID: PMC4292784, DOI: 10.3389/fcimb.2014.00194.Peer-Reviewed Original ResearchConceptsNasopharyngeal environmentConcomitant virus infectionPneumococcal biofilmsMiddle ear infectionRespiratory epithelial cellsMillions of infectionsPneumococcal biofilm formationPneumococcal diseaseEar infectionsSterile sitesInvasive diseasePneumococcal colonizationHigh prevalenceVirus infectionDisease processDistinct phenotypic propertiesMucosal surfacesStreptococcus pneumoniaeVaccine escapeHuman nasopharynxDiseaseEpithelial cellsInfectionPneumococciAntibiotic resistance
2011
Streptococcus pneumoniae Clonal Complex 199: Genetic Diversity and Tissue-Specific Virulence
Thomas JC, Figueira M, Fennie KP, Laufer AS, Kong Y, Pichichero ME, Pelton SI, Pettigrew MM. Streptococcus pneumoniae Clonal Complex 199: Genetic Diversity and Tissue-Specific Virulence. PLOS ONE 2011, 6: e18649. PMID: 21533186, PMCID: PMC3077395, DOI: 10.1371/journal.pone.0018649.Peer-Reviewed Original ResearchConceptsChinchilla modelHeptavalent pneumococcal conjugate vaccinePneumococcal conjugate vaccineSerotype 19A isolatesMiddle ear isolatesS. pneumoniae isolatesLong-term effectivenessConjugate vaccinePneumococcal diseaseOtitis mediaVaccinated populationReplacement diseaseBlood isolatesInvasive diseaseCarriage isolatesPneumoniae isolatesCerebrospinal fluidEar isolatesFuture vaccinesImportant causeStreptococcus pneumoniaeMiddle earDiseaseVirulence potentialVaccine
2006
Variation in the Presence of Neuraminidase Genes among Streptococcus pneumoniae Isolates with Identical Sequence Types
Pettigrew MM, Fennie KP, York MP, Daniels J, Ghaffar F. Variation in the Presence of Neuraminidase Genes among Streptococcus pneumoniae Isolates with Identical Sequence Types. Infection And Immunity 2006, 74: 3360-3365. PMID: 16714565, PMCID: PMC1479257, DOI: 10.1128/iai.01442-05.Peer-Reviewed Original ResearchConceptsPneumoniae isolatesSequence typesUpper respiratory tractNeuraminidase geneS. pneumoniae isolatesVirulence determinantsStreptococcus pneumoniae isolatesIdentical sequence typesYoung childrenAdditional virulence determinantsSialic acid-containing substratesCapsule typesMultilocus sequence typesOtitis mediaInvasive diseaseRespiratory tractCarriage isolatesPneumococcal clonesSame sequence typePneumococcal strainsImportant causeStreptococcus pneumoniaeMiddle earDifferent tissue sourcesPneumococcal neuraminidase