2022
Impact of antibiotics on off-target infant gut microbiota and resistance genes in cohort studies
Lebeaux RM, Madan JC, Nguyen QP, Coker MO, Dade EF, Moroishi Y, Palys TJ, Ross BD, Pettigrew MM, Morrison HG, Karagas MR, Hoen AG. Impact of antibiotics on off-target infant gut microbiota and resistance genes in cohort studies. Pediatric Research 2022, 92: 1757-1766. PMID: 35568730, PMCID: PMC9659678, DOI: 10.1038/s41390-022-02104-w.Peer-Reviewed Original ResearchConceptsAntibiotic exposureCohort studyDay careDay care attendanceInfant gut microbiotaAntibiotic resistance genesCare attendanceImpact of antibioticsAntibiotic useStool samplesGut microbiotaInfantsGut microbiomeStudy designBacteroides fragilisAntibioticsBackgroundYoung childrenNovel findingsSubsequent exposureExposureFirst yearFurther investigationBaselineResistance genesCare
2007
Respiratory symptoms among infants at risk for asthma: association with surfactant protein A haplotypes
Pettigrew MM, Gent JF, Zhu Y, Triche EW, Belanger KD, Holford TR, Bracken MB, Leaderer BP. Respiratory symptoms among infants at risk for asthma: association with surfactant protein A haplotypes. BMC Medical Genomics 2007, 8: 15. PMID: 17407567, PMCID: PMC1852548, DOI: 10.1186/1471-2350-8-15.Peer-Reviewed Original ResearchConceptsPersistent coughSurfactant protein ARespiratory symptomsWhite infantsClinician-diagnosed asthmaInfant respiratory symptomsRespiratory symptom frequencyRisk of wheezeCohort of infantsSingle nucleotide polymorphismsMonths of ageQuarterly telephone interviewsLogistic regression modelsRace/ethnicityStudy infantsNewborn infantsSymptom frequencyInfant's birthStandardized questionnaireCoughWheezeAsthmaInfantsTelephone interviewsOlder children
2006
Association of surfactant protein A polymorphisms with otitis media in infants at risk for asthma
Pettigrew MM, Gent JF, Zhu Y, Triche EW, Belanger KD, Holford TR, Bracken MB, Leaderer BP. Association of surfactant protein A polymorphisms with otitis media in infants at risk for asthma. BMC Medical Genomics 2006, 7: 68. PMID: 16884531, PMCID: PMC1557482, DOI: 10.1186/1471-2350-7-68.Peer-Reviewed Original ResearchConceptsOtitis mediaWhite infantsInfant respiratory symptomsPhysician-diagnosed asthmaCohort of infantsLarger confirmatory studiesSurfactant proteinsInnate immune responseMonths of ageQuarterly telephone interviewsLogistic regression modelsRace/ethnicityRespiratory symptomsCommon infectionsProspective studyImmune responseStudy populationInfant's birthStandardized questionnaireInfantsConclusionThese resultsAsthmaTelephone interviewsConfirmatory studiesWhole blood
2003
Duration of Breastfeeding, Daycare, and Physician Visits among Infants 6 Months and Younger
Pettigrew MM, Khodaee M, Gillespie B, Schwartz K, Bobo JK, Foxman B. Duration of Breastfeeding, Daycare, and Physician Visits among Infants 6 Months and Younger. Annals Of Epidemiology 2003, 13: 431-435. PMID: 12875801, DOI: 10.1016/s1047-2797(02)00463-5.Peer-Reviewed Original ResearchConceptsDuration of breastfeedingAdditional childrenInfants 6 monthsHealth care providersFirstborn childrenPhysician visitsWeeks postpartumMonths postpartumBirthing centerCare providersBreastfeedingNumber of childrenAdditional weeksMailed questionnaireInfantsWomenChildrenPostpartumDurationVisitsMonthsDaycareSuburban DetroitIllnessWeeks