2023
Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study
Sanft T, Harrigan M, McGowan C, Cartmel B, Zupa M, Li F, Ferrucci L, Puklin L, Cao A, Nguyen T, Neuhouser M, Hershman D, Basen-Engquist K, Jones B, Knobf T, Chagpar A, Silber A, Tanasijevic A, Ligibel J, Irwin M. Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study. Journal Of Clinical Oncology 2023, 41: 5285-5295. PMID: 37656930, PMCID: PMC10691793, DOI: 10.1200/jco.23.00871.Peer-Reviewed Original ResearchConceptsRelative dose intensityPathologic complete responseProportion of patientsBreast cancerNeoadjuvant chemotherapyChemotherapy completionComplete responseNutrition interventionsHigher pathologic complete responseHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Triple-negative breast cancerChemotherapy dose adjustmentsHome-based exerciseGrowth factor receptor 2Breast cancer outcomesEffects of exerciseFactor receptor 2Electronic medical recordsChi-square testUsual careDose intensityExercise interventionDose adjustmentRandomized trials
2022
A competing risk analysis of adherence to the American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention and obesity‐related cancer risk in Hispanic/Latino adults in the NIH‐AARP Diet and Health Study
Pichardo MS, Irwin ML, Esserman D, Molina Y, Ferrucci LM. A competing risk analysis of adherence to the American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention and obesity‐related cancer risk in Hispanic/Latino adults in the NIH‐AARP Diet and Health Study. International Journal Of Cancer 2022, 151: 1902-1912. PMID: 35802472, PMCID: PMC9588580, DOI: 10.1002/ijc.34200.Peer-Reviewed Original ResearchConceptsHispanic/Latino adultsObesity-related cancersUS Hispanic/Latino adultsAmerican Cancer Society guidelinesNIH-AARP DietHealthy lifestyle behaviorsGuideline adherenceLatino adultsSociety guidelinesLifestyle behaviorsCancer preventionPhysical activityCancer riskHealth StudyObesity-related cancer riskPublic health effortsHypothesized inverse associationMagnitude of riskAdherence categoriesInverse associationCancer incidenceACS guidelinesHigh adherenceCumulative riskHealth effortsExercise, Diet, and Weight Management During Cancer Treatment: ASCO Guideline
Ligibel JA, Bohlke K, May AM, Clinton SK, Demark-Wahnefried W, Gilchrist SC, Irwin ML, Late M, Mansfield S, Marshall TF, Meyerhardt JA, Thomson CA, Wood WA, Alfano CM. Exercise, Diet, and Weight Management During Cancer Treatment: ASCO Guideline. Journal Of Clinical Oncology 2022, 40: 2491-2507. PMID: 35576506, DOI: 10.1200/jco.22.00687.Peer-Reviewed Original ResearchConceptsWeight loss interventionCancer treatmentSystematic reviewNeutropenic dietPreoperative exerciseLoss interventionActive treatmentResistance exerciseLung cancerWeight managementActive cancer treatmentIntentional weight lossPatient-reported outcomesRisk of infectionQuality of lifeTypes of cancerCurative intentASCO guidelinesHospital stayPostoperative lengthTreatment toxicityOncology providersAdvanced cancerCochrane LibraryCardiorespiratory fitness
2021
Race, Income, and Survival in Stage III Colon Cancer: CALGB 89803 (Alliance)
Lee S, Zhang S, Ma C, Ou FS, Wolfe EG, Ogino S, Niedzwiecki D, Saltz LB, Mayer RJ, Mowat RB, Whittom R, Hantel A, Benson A, Atienza D, Messino M, Kindler H, Venook A, Gross CP, Irwin ML, Meyerhardt JA, Fuchs CS. Race, Income, and Survival in Stage III Colon Cancer: CALGB 89803 (Alliance). JNCI Cancer Spectrum 2021, 5: pkab034-. PMID: 34104867, PMCID: PMC8178799, DOI: 10.1093/jncics/pkab034.Peer-Reviewed Original ResearchMeSH KeywordsAgedBlack PeopleChemotherapy, AdjuvantColonic NeoplasmsConfidence IntervalsDietDisease-Free SurvivalFemaleHealth Services AccessibilityHumansIncomeLife StyleMaleMiddle AgedMultivariate AnalysisNeoplasm Recurrence, LocalNeoplasm StagingProportional Hazards ModelsProspective StudiesWhite PeopleConceptsAdjusted hazard ratioDisease-free survivalRecurrence-free survivalColon cancer patientsHome zip codeMedian household incomeCALGB 89803Hazard ratioOverall survivalCancer patientsStage III colon cancer patientsStage III colon cancerPatient's home zip codeAdjuvant chemotherapy trialsStudy of patientsColon cancer outcomesHealth care accessChemotherapy trialsStudy enrollmentBlack patientsCancer outcomesLifestyle factorsLowest quartileObservational studyPatients
2020
Skin carotenoids are inversely associated with adiposity in breast cancer survivors
Cartmel B, Anderson C, Irwin ML, Harrigan M, Sanft T, Li F, Gellermann W, Ermakov IV, Ferrucci LM. Skin carotenoids are inversely associated with adiposity in breast cancer survivors. Nutrition Research 2020, 79: 77-86. PMID: 32650223, PMCID: PMC7409553, DOI: 10.1016/j.nutres.2020.05.012.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsSkin carotenoid scoreUsual care groupCancer survivorsSkin carotenoidsBody fatCare groupSerum biomarkersAdiposity measuresLog C-reactive protein levelsBaseline percent body fatObese breast cancer survivorsC-reactive protein levelsDual-energy X-ray absorptiometryStrong associationBreast cancer patientsWeight loss trialStudy of overweightTotal body fatPercent body fatX-ray absorptiometryLog leptinPoor outcomeCancer patientsHip circumference
2008
Impact of Nutrition and Exercise on Cancer Survival
Irwin ML, Mayne ST. Impact of Nutrition and Exercise on Cancer Survival. The Cancer Journal 2008, 14: 435-441. PMID: 19060611, DOI: 10.1097/ppo.0b013e31818daeee.Peer-Reviewed Original ResearchConceptsCancer survivorsSupplement useCancer survivalAdverse prognostic factorPhysical activity recommendationsNutrient supplement useAmerican Cancer SocietyLifestyle-based approachLong-term survivalImpact of nutritionLifestyle interventionPrognostic factorsRandomized trialsCancer outcomesPhysical inactivityActivity recommendationsCurrent guidelinesNumber of menCancer SocietyPhysical activityWeight gainAvailable evidenceSurvivorsSurvivalObesity