2022
Cardiometabolic risk factors, physical activity, and postmenopausal breast cancer mortality: results from the Women’s Health Initiative
Dieli-Conwright CM, Nelson RA, Simon MS, Irwin ML, Neuhouser ML, Reding KW, Crane TE, Manson JE, Nassir R, Shadyab AH, LaMonte M, Qi L, Thomson CA, Kroenke CH, Pan K, Chlebowski RT, Mortimer J. Cardiometabolic risk factors, physical activity, and postmenopausal breast cancer mortality: results from the Women’s Health Initiative. BMC Women's Health 2022, 22: 32. PMID: 35120497, PMCID: PMC8817588, DOI: 10.1186/s12905-022-01614-3.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsCardiometabolic Risk FactorsExerciseFemaleHumansMetabolic SyndromePostmenopauseProportional Hazards ModelsRisk FactorsWomen's HealthConceptsBreast cancer-specific mortalityCancer-specific mortalityWomen's Health Initiative participantsEarly-stage breast cancerCardiometabolic risk factorsBreast cancer mortalityPhysical activity levelsRisk factor numberPhysical activityBreast cancerRisk factorsCancer mortalityHigher breast cancer-specific mortalityLower breast cancer-specific mortalityInitiative participantsHealth initiativesNational Death Index queryProportional hazards regression modelsHigher physical activity levelsCancer diagnosisMetabolic syndrome componentsBaseline physical activityHigh waist circumferenceMedical record reviewCause mortality risk
2021
Analysis of Survival Among Adults With Early-Onset Colorectal Cancer in the National Cancer Database
Cheng E, Blackburn HN, Ng K, Spiegelman D, Irwin ML, Ma X, Gross CP, Tabung FK, Giovannucci EL, Kunz PL, Llor X, Billingsley K, Meyerhardt JA, Ahuja N, Fuchs CS. Analysis of Survival Among Adults With Early-Onset Colorectal Cancer in the National Cancer Database. JAMA Network Open 2021, 4: e2112539. PMID: 34132794, PMCID: PMC8209612, DOI: 10.1001/jamanetworkopen.2021.12539.Peer-Reviewed Original ResearchConceptsEarly-onset colorectal cancerOnset colorectal cancerNational Cancer DatabaseColorectal cancerAge 51Overall survivalCancer DatabaseIncidence of CRCCox proportional hazards regressionPrimary colorectal cancerKaplan-Meier analysisProportional hazards regressionAge 50 yearsAge 25 yearsAnalysis of survivalCohort studySurvival benefitHazards regressionUnadjusted analysesCancer incidenceMAIN OUTCOMEAge 35Survival advantageLower riskStage IRace, Income, and Survival in Stage III Colon Cancer: CALGB 89803 (Alliance)
Lee S, Zhang S, Ma C, Ou FS, Wolfe EG, Ogino S, Niedzwiecki D, Saltz LB, Mayer RJ, Mowat RB, Whittom R, Hantel A, Benson A, Atienza D, Messino M, Kindler H, Venook A, Gross CP, Irwin ML, Meyerhardt JA, Fuchs CS. Race, Income, and Survival in Stage III Colon Cancer: CALGB 89803 (Alliance). JNCI Cancer Spectrum 2021, 5: pkab034-. PMID: 34104867, PMCID: PMC8178799, DOI: 10.1093/jncics/pkab034.Peer-Reviewed Original ResearchMeSH KeywordsAgedBlack PeopleChemotherapy, AdjuvantColonic NeoplasmsConfidence IntervalsDietDisease-Free SurvivalFemaleHealth Services AccessibilityHumansIncomeLife StyleMaleMiddle AgedMultivariate AnalysisNeoplasm Recurrence, LocalNeoplasm StagingProportional Hazards ModelsProspective StudiesWhite PeopleConceptsAdjusted hazard ratioDisease-free survivalRecurrence-free survivalColon cancer patientsHome zip codeMedian household incomeCALGB 89803Hazard ratioOverall survivalCancer patientsStage III colon cancer patientsStage III colon cancerPatient's home zip codeAdjuvant chemotherapy trialsStudy of patientsColon cancer outcomesHealth care accessChemotherapy trialsStudy enrollmentBlack patientsCancer outcomesLifestyle factorsLowest quartileObservational studyPatients
2014
Body mass index, physical activity, and mortality in women diagnosed with ovarian cancer: Results from the Women's Health Initiative
Zhou Y, Chlebowski R, LaMonte MJ, Bea JW, Qi L, Wallace R, Lavasani S, Walsh BW, Anderson G, Vitolins M, Sarto G, Irwin ML. Body mass index, physical activity, and mortality in women diagnosed with ovarian cancer: Results from the Women's Health Initiative. Gynecologic Oncology 2014, 133: 4-10. PMID: 24680584, PMCID: PMC4064800, DOI: 10.1016/j.ygyno.2014.01.033.Peer-Reviewed Original ResearchMeSH KeywordsAgedBody Mass IndexCause of DeathCohort StudiesExerciseFemaleHumansMiddle AgedMotor ActivityObesityOvarian NeoplasmsOverweightProportional Hazards ModelsProspective StudiesRisk FactorsConceptsWomen's Health InitiativeBody mass indexVigorous-intensity physical activityOvarian cancerPhysical activityHealth initiativesLower riskCause mortalityMass indexSelf-reported physical activityOvarian cancer mortalityModifiable lifestyle factorsProportional hazards regressionPrimary ovarian cancerOvarian cancer diagnosisPostmenopausal womenBaseline visitHazards regressionLifestyle factorsCancer mortalityMortality endpointsSurvival rateMortalityCancerCancer diagnosis
2008
Influence of Pre- and Postdiagnosis Physical Activity on Mortality in Breast Cancer Survivors: The Health, Eating, Activity, and Lifestyle Study
Irwin ML, Smith AW, McTiernan A, Ballard-Barbash R, Cronin K, Gilliland FD, Baumgartner RN, Baumgartner KB, Bernstein L. Influence of Pre- and Postdiagnosis Physical Activity on Mortality in Breast Cancer Survivors: The Health, Eating, Activity, and Lifestyle Study. Journal Of Clinical Oncology 2008, 26: 3958-3964. PMID: 18711185, PMCID: PMC2654316, DOI: 10.1200/jco.2007.15.9822.Peer-Reviewed Original ResearchConceptsPhysical activityBreast cancerHazard ratioLifestyle StudyTotal deathsModerate-intensity physical activityMultivariable hazard ratiosPostdiagnosis physical activityProspective observational studyBreast cancer deathsBreast cancer survivorsMetabolic equivalent hoursRegional breast cancerPostdiagnosis changesPrimary outcomeCancer survivorsPrimary exposureCancer deathInactive womenObservational studyLower riskGreater riskDiagnosisInfluence of preWomen