2023
Structural Racism, Lifestyle Behaviors, and Obesity-related Cancers among Black and Hispanic/Latino Adults in the United States: A Narrative Review.
Pichardo M, Ferrucci L, Molina Y, Esserman D, Irwin M. Structural Racism, Lifestyle Behaviors, and Obesity-related Cancers among Black and Hispanic/Latino Adults in the United States: A Narrative Review. Cancer Epidemiology Biomarkers & Prevention 2023, 32: 1498-1507. PMID: 37650844, PMCID: PMC10872641, DOI: 10.1158/1055-9965.epi-22-1147.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlack or African AmericanHispanic or LatinoHumansLife StyleNeoplasmsObesitySystemic RacismUnited StatesConceptsHispanic/Latino adultsObesity-related cancersLifestyle behaviorsLatino adultsLifestyle guidelinesCancer preventionPoor lifestyle behaviorsU.S. Hispanic/Latino adultsHealthful lifestyle behaviorsCause of deathHealthy lifestyle choicesChronic diseasesCardiovascular diseaseCommon causeCancer riskNarrative reviewBlack adultsDisproportionate burdenObesityCancerAdultsLifestyle choicesDiseasePreventionDeathEffect of Exercise on Chemotherapy-Induced Peripheral Neuropathy Among Patients Treated for Ovarian Cancer
Cao A, Cartmel B, Li F, Gottlieb L, Harrigan M, Ligibel J, Gogoi R, Schwartz P, Esserman D, Irwin M, Ferrucci L. Effect of Exercise on Chemotherapy-Induced Peripheral Neuropathy Among Patients Treated for Ovarian Cancer. JAMA Network Open 2023, 6: e2326463. PMID: 37526937, PMCID: PMC10394582, DOI: 10.1001/jamanetworkopen.2023.26463.Peer-Reviewed Original ResearchConceptsChemotherapy-induced peripheral neuropathyAerobic exercise interventionAttention control armExercise intervention armExercise interventionOvarian cancerControl armIntervention armSecondary analysisCIPN symptomsPeripheral neuropathyLifestyle StudyTreatment of CIPNModerate-intensity aerobic exerciseStandard oncology careEffects of exerciseSevere adverse effectsBetween-group differencesAmerican Cancer SocietyQuality of lifeAttention controlCIPN severityPrimary outcomeOncology careAerobic exercise
2022
Adherence to the American Cancer Society Guidelines on nutrition and physical activity for cancer prevention and obesity‐related cancer risk and mortality in Black and Latina Women's Health Initiative participants
Pichardo MS, Esserman D, Ferrucci LM, Molina Y, Chlebowski RT, Pan K, Garcia DO, Lane DS, Shadyab AH, Lopez‐Pentecost M, Luo J, Kato I, Springfield S, Rosal MC, Bea JW, Feliciano E, Qi L, Nassir R, Snetselaar L, Manson J, Bird C, Irwin ML. Adherence to the American Cancer Society Guidelines on nutrition and physical activity for cancer prevention and obesity‐related cancer risk and mortality in Black and Latina Women's Health Initiative participants. Cancer 2022, 128: 3630-3640. PMID: 35996861, DOI: 10.1002/cncr.34428.Peer-Reviewed Original ResearchMeSH KeywordsAmerican Cancer SocietyExerciseFemaleHispanic or LatinoHumansNeoplasmsObesityRisk FactorsUnited StatesWomen's HealthConceptsAmerican Cancer Society guidelinesObesity-related cancersWomen's Health InitiativeGuideline adherenceSociety guidelinesHealth initiativesPhysical activityLower riskEffect modificationCancer preventionObesity-related cancer incidenceObesity-related cancer riskWomen's Health Initiative participantsLatina womenPotential effect modificationPublic health interventionsNeighborhood socioeconomic statusCause deathCause mortalityLifestyle guidelinesPostmenopausal womenCancer incidenceLower incidenceACS guidelinesHigh adherenceA competing risk analysis of adherence to the American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention and obesity‐related cancer risk in Hispanic/Latino adults in the NIH‐AARP Diet and Health Study
Pichardo MS, Irwin ML, Esserman D, Molina Y, Ferrucci LM. A competing risk analysis of adherence to the American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Prevention and obesity‐related cancer risk in Hispanic/Latino adults in the NIH‐AARP Diet and Health Study. International Journal Of Cancer 2022, 151: 1902-1912. PMID: 35802472, PMCID: PMC9588580, DOI: 10.1002/ijc.34200.Peer-Reviewed Original ResearchMeSH KeywordsAmerican Cancer SocietyDietExerciseHispanic or LatinoHumansNeoplasmsObesityRisk AssessmentRisk FactorsUnited StatesConceptsHispanic/Latino adultsObesity-related cancersUS Hispanic/Latino adultsAmerican Cancer Society guidelinesNIH-AARP DietHealthy lifestyle behaviorsGuideline adherenceLatino adultsSociety guidelinesLifestyle behaviorsCancer preventionPhysical activityCancer riskHealth StudyObesity-related cancer riskPublic health effortsHypothesized inverse associationMagnitude of riskAdherence categoriesInverse associationCancer incidenceACS guidelinesHigh adherenceCumulative riskHealth effortsOral Cyanobacteria and Hepatocellular Carcinoma
Hernandez BY, Zhu X, Risch HA, Lu L, Ma X, Irwin ML, Lim JK, Taddei TH, Pawlish KS, Stroup AM, Brown R, Wang Z, Wong LL, Yu H. Oral Cyanobacteria and Hepatocellular Carcinoma. Cancer Epidemiology Biomarkers & Prevention 2022, 31: 221-229. PMID: 34697061, PMCID: PMC8755591, DOI: 10.1158/1055-9965.epi-21-0804.Peer-Reviewed Original ResearchConceptsHepatitis B virusHepatitis C virusHepatocellular carcinomaRisk factorsLiver diseaseHCC casesOral microbiomeU.S. case-control studyIndependent risk factorChronic liver diseaseFatty liver diseaseHCC risk factorsGut microbial alterationsType 2 diabetesCase-control studyLiver cancer developmentNSAID useAspirin useC virusB virusHCC riskNegative historyOral samplesSignificant associationCancer development
2021
Neighborhood and Individual Socioeconomic Disadvantage and Survival Among Patients With Nonmetastatic Common Cancers
Cheng E, Soulos PR, Irwin ML, Feliciano E, Presley CJ, Fuchs CS, Meyerhardt JA, Gross CP. Neighborhood and Individual Socioeconomic Disadvantage and Survival Among Patients With Nonmetastatic Common Cancers. JAMA Network Open 2021, 4: e2139593. PMID: 34919133, PMCID: PMC8683967, DOI: 10.1001/jamanetworkopen.2021.39593.Peer-Reviewed Original ResearchConceptsCancer-specific mortalityNeighborhood socioeconomic statusIndividual-level socioeconomic statusIndividual socioeconomic statusColorectal cancerOverall mortalitySocioeconomic statusCohort studyHazard ratioDual eligibilityCancer patientsCommon cancerLung cancerProstate cancerSocioeconomic disadvantageHigh riskEnd Results-Medicare databaseMedicare-Medicaid dual eligibilityPopulation-based cohort studyCox proportional hazards regressionSuboptimal cancer careColorectal cancer patientsBreast cancer patientsProportional hazards regressionNon-Hispanic white individualsAnalysis of Survival Among Adults With Early-Onset Colorectal Cancer in the National Cancer Database
Cheng E, Blackburn HN, Ng K, Spiegelman D, Irwin ML, Ma X, Gross CP, Tabung FK, Giovannucci EL, Kunz PL, Llor X, Billingsley K, Meyerhardt JA, Ahuja N, Fuchs CS. Analysis of Survival Among Adults With Early-Onset Colorectal Cancer in the National Cancer Database. JAMA Network Open 2021, 4: e2112539. PMID: 34132794, PMCID: PMC8209612, DOI: 10.1001/jamanetworkopen.2021.12539.Peer-Reviewed Original ResearchConceptsEarly-onset colorectal cancerOnset colorectal cancerNational Cancer DatabaseColorectal cancerAge 51Overall survivalCancer DatabaseIncidence of CRCCox proportional hazards regressionPrimary colorectal cancerKaplan-Meier analysisProportional hazards regressionAge 50 yearsAge 25 yearsAnalysis of survivalCohort studySurvival benefitHazards regressionUnadjusted analysesCancer incidenceMAIN OUTCOMEAge 35Survival advantageLower riskStage IEfficacy of Weight Loss Interventions in United States Active Duty Military Populations: A Systematic Review
Csizmar G, Irwin M. Efficacy of Weight Loss Interventions in United States Active Duty Military Populations: A Systematic Review. Military Medicine 2021, 186: 1093-1099. PMID: 33506251, DOI: 10.1093/milmed/usab012.Peer-Reviewed Original ResearchConceptsDuty service membersActive duty service membersEfficacy of weight loss interventionsWeight loss interventionService membersSystematic reviewActive duty military populationOverseas contingency operationsElectronic databases PubMedPolicy changesNational securityPolicy effortsFood environmentLifestyle interventionUnderdeveloped researchPrevention effortsMilitary populationDoD leadersInclusion criteriaMeasured outcomesMilitary membersDatabases PubMedTarget populationInterventionMember moves
2020
Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial
Brown JC, Zhang S, Ligibel JA, Irwin ML, Jones LW, Campbell N, Pollak MN, Sorrentino A, Cartmel B, Harrigan M, Tolaney SM, Winer EP, Ng K, Abrams TA, Sanft T, Douglas PS, Hu FB, Fuchs CS, Meyerhardt JA. Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial. Cancer Prevention Research 2020, 13: 1055-1062. PMID: 32859615, PMCID: PMC7718298, DOI: 10.1158/1940-6207.capr-20-0188.Peer-Reviewed Original ResearchConceptsHs-CRPColorectal cancerPhysical activityHigh-sensitivity C-reactive proteinLow baseline physical activitySurvivors of breastTrial product estimandBaseline physical activityBiomarkers of inflammationC-reactive proteinMeasures of inflammationImproved clinical outcomesEffects of exerciseType 2 diabetesCombination of exerciseStandard therapyClinical outcomesCancer recurrenceObservational studyTreatment groupsInflammation outcomesMetforminIL6Factorial trialInflammationTransdisciplinary Research in Energetics and Cancer early career investigator training program: first year results
Irwin ML, Lowry D, Neuhouser ML, Ligibel J, Schmitz K, Patterson RE, Colditz G, Li F, Nebeling L. Transdisciplinary Research in Energetics and Cancer early career investigator training program: first year results. Translational Behavioral Medicine 2020, 11: 549-562. PMID: 32065834, PMCID: PMC7963289, DOI: 10.1093/tbm/ibaa009.Peer-Reviewed Original ResearchMeSH KeywordsHumansInterdisciplinary ResearchMentoringMentorsNeoplasmsResearch PersonnelUnited StatesConceptsYear of mentorshipYear 1 participantsEarly career investigatorsCancer burdenCancer riskHealth of populationsMentorship periodTraining programProgram satisfactionGroup sessionsCancer researchSmall group sessionsYear resultsFirst year resultsRiskEnergy imbalanceProgram impactFifth yearCourseInvestigatorsSessionsFellowsYearsCancerMortality
2012
Obesity and endometrial cancer survival: a systematic review
Arem H, Irwin M. Obesity and endometrial cancer survival: a systematic review. International Journal Of Obesity 2012, 37: 634-639. PMID: 22710929, PMCID: PMC3774112, DOI: 10.1038/ijo.2012.94.Peer-Reviewed Original ResearchConceptsEndometrial cancer survivorsDisease-specific mortalityEndometrial cancerCancer survivorsGeneral populationObesity-related mortalityProgression-free survivalEndometrial cancer survivalBody mass indexPopulation of womenHigh mortality rateMagnitude of associationMultivariate adjustmentHealthy womenMass indexProspective studyCancer survivalInclusion criteriaMEDLINE searchMortality rateObesitySystematic reviewSignificant associationMortalityMeSH keywords
2004
Physical activity levels among breast cancer survivors.
Irwin ML, McTiernan A, Bernstein L, Gilliland FD, Baumgartner R, Baumgartner K, Ballard-Barbash R. Physical activity levels among breast cancer survivors. Medicine & Science In Sports & Exercise 2004, 36: 1484-91. PMID: 15354027, PMCID: PMC3000611.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBreast NeoplasmsEthnicityExerciseFemaleHumansMiddle AgedSurvivorsUnited StatesConceptsBreast cancer survivorsHispanic breast cancer survivorsLevel of PACancer survivorsPhysical activityWeight gainBlack breast cancer survivorsObese breast cancer survivorsSurveillance Epidemiology End ResultsPostdiagnosis weight gainNegative prognostic factorBreast cancer survivalRecreational physical activityPhysical activity levelsGeneral adult populationBreast cancer prognosisNon-Hispanic whitesCategories of adiposityPrognostic factorsType of sportDisease stageCancer survivalLifestyle StudyBreast cancerPA recommendations