2021
Neighborhood and Individual Socioeconomic Disadvantage and Survival Among Patients With Nonmetastatic Common Cancers
Cheng E, Soulos PR, Irwin ML, Feliciano E, Presley CJ, Fuchs CS, Meyerhardt JA, Gross CP. Neighborhood and Individual Socioeconomic Disadvantage and Survival Among Patients With Nonmetastatic Common Cancers. JAMA Network Open 2021, 4: e2139593. PMID: 34919133, PMCID: PMC8683967, DOI: 10.1001/jamanetworkopen.2021.39593.Peer-Reviewed Original ResearchConceptsCancer-specific mortalityNeighborhood socioeconomic statusIndividual-level socioeconomic statusIndividual socioeconomic statusColorectal cancerOverall mortalitySocioeconomic statusCohort studyHazard ratioDual eligibilityCancer patientsCommon cancerLung cancerProstate cancerSocioeconomic disadvantageHigh riskEnd Results-Medicare databaseMedicare-Medicaid dual eligibilityPopulation-based cohort studyCox proportional hazards regressionSuboptimal cancer careColorectal cancer patientsBreast cancer patientsProportional hazards regressionNon-Hispanic white individualsPrediagnosis and postdiagnosis leisure time physical activity and survival following diagnosis with ovarian cancer
Wang T, Townsend MK, Eliassen AH, Terry KL, Song M, Irwin ML, Tworoger SS. Prediagnosis and postdiagnosis leisure time physical activity and survival following diagnosis with ovarian cancer. International Journal Of Cancer 2021, 149: 1067-1075. PMID: 33963766, PMCID: PMC8282739, DOI: 10.1002/ijc.33676.Peer-Reviewed Original ResearchConceptsOvarian cancer-specific mortalityCancer-specific mortalityNurses' Health StudyPhysical activityHazard ratioOvarian cancerHealth StudyWeek 1MET-hours/weekLow-grade serous tumorsLeisure-time physical activityPostdiagnosis physical activityRisk of deathEpithelial ovarian cancerOvarian cancer survivalConfidence intervalsTime physical activityOvarian cancer diagnosisBetter prognosisSerous tumorsCancer survivalInverse associationLarge cohortDiagnosisCancer diagnosisRace, Income, and Survival in Stage III Colon Cancer: CALGB 89803 (Alliance)
Lee S, Zhang S, Ma C, Ou FS, Wolfe EG, Ogino S, Niedzwiecki D, Saltz LB, Mayer RJ, Mowat RB, Whittom R, Hantel A, Benson A, Atienza D, Messino M, Kindler H, Venook A, Gross CP, Irwin ML, Meyerhardt JA, Fuchs CS. Race, Income, and Survival in Stage III Colon Cancer: CALGB 89803 (Alliance). JNCI Cancer Spectrum 2021, 5: pkab034-. PMID: 34104867, PMCID: PMC8178799, DOI: 10.1093/jncics/pkab034.Peer-Reviewed Original ResearchMeSH KeywordsAgedBlack PeopleChemotherapy, AdjuvantColonic NeoplasmsConfidence IntervalsDietDisease-Free SurvivalFemaleHealth Services AccessibilityHumansIncomeLife StyleMaleMiddle AgedMultivariate AnalysisNeoplasm Recurrence, LocalNeoplasm StagingProportional Hazards ModelsProspective StudiesWhite PeopleConceptsAdjusted hazard ratioDisease-free survivalRecurrence-free survivalColon cancer patientsHome zip codeMedian household incomeCALGB 89803Hazard ratioOverall survivalCancer patientsStage III colon cancer patientsStage III colon cancerPatient's home zip codeAdjuvant chemotherapy trialsStudy of patientsColon cancer outcomesHealth care accessChemotherapy trialsStudy enrollmentBlack patientsCancer outcomesLifestyle factorsLowest quartileObservational studyPatients
2014
Body mass index, physical activity, and mortality in women diagnosed with ovarian cancer: Results from the Women's Health Initiative
Zhou Y, Chlebowski R, LaMonte MJ, Bea JW, Qi L, Wallace R, Lavasani S, Walsh BW, Anderson G, Vitolins M, Sarto G, Irwin ML. Body mass index, physical activity, and mortality in women diagnosed with ovarian cancer: Results from the Women's Health Initiative. Gynecologic Oncology 2014, 133: 4-10. PMID: 24680584, PMCID: PMC4064800, DOI: 10.1016/j.ygyno.2014.01.033.Peer-Reviewed Original ResearchConceptsWomen's Health InitiativeBody mass indexVigorous-intensity physical activityOvarian cancerPhysical activityHealth initiativesLower riskCause mortalityMass indexSelf-reported physical activityOvarian cancer mortalityModifiable lifestyle factorsProportional hazards regressionPrimary ovarian cancerOvarian cancer diagnosisPostmenopausal womenBaseline visitHazards regressionLifestyle factorsCancer mortalityMortality endpointsSurvival rateMortalityCancerCancer diagnosis
2010
Fasting C-Peptide Levels and Death Resulting From All Causes and Breast Cancer: The Health, Eating, Activity, and Lifestyle Study
Irwin ML, Duggan C, Wang CY, Smith AW, McTiernan A, Baumgartner RN, Baumgartner KB, Bernstein L, Ballard-Barbash R. Fasting C-Peptide Levels and Death Resulting From All Causes and Breast Cancer: The Health, Eating, Activity, and Lifestyle Study. Journal Of Clinical Oncology 2010, 29: 47-53. PMID: 21115859, PMCID: PMC3055859, DOI: 10.1200/jco.2010.28.4752.Peer-Reviewed Original ResearchConceptsC-peptide levelsRisk of deathType 2 diabetesBreast cancerHazard ratioLifestyle StudyC-peptideDietary-induced weight lossSerum C-peptideCox regression analysisBody mass indexRegional breast cancerBreast cancer diagnosisMass indexInsulin secretionTreatment strategiesObservational studyEstrogen receptorPhysical activityCancerWeight lossCancer diagnosisCertain subgroupsWomenDeath
2008
Influence of Pre- and Postdiagnosis Physical Activity on Mortality in Breast Cancer Survivors: The Health, Eating, Activity, and Lifestyle Study
Irwin ML, Smith AW, McTiernan A, Ballard-Barbash R, Cronin K, Gilliland FD, Baumgartner RN, Baumgartner KB, Bernstein L. Influence of Pre- and Postdiagnosis Physical Activity on Mortality in Breast Cancer Survivors: The Health, Eating, Activity, and Lifestyle Study. Journal Of Clinical Oncology 2008, 26: 3958-3964. PMID: 18711185, PMCID: PMC2654316, DOI: 10.1200/jco.2007.15.9822.Peer-Reviewed Original ResearchConceptsPhysical activityBreast cancerHazard ratioLifestyle StudyTotal deathsModerate-intensity physical activityMultivariable hazard ratiosPostdiagnosis physical activityProspective observational studyBreast cancer deathsBreast cancer survivorsMetabolic equivalent hoursRegional breast cancerPostdiagnosis changesPrimary outcomeCancer survivorsPrimary exposureCancer deathInactive womenObservational studyLower riskGreater riskDiagnosisInfluence of preWomen
2005
Relationship of Obesity and Physical Activity with C-Peptide, Leptin, and Insulin-Like Growth Factors in Breast Cancer Survivors
Irwin ML, McTiernan A, Bernstein L, Gilliland FD, Baumgartner R, Baumgartner K, Ballard-Barbash R. Relationship of Obesity and Physical Activity with C-Peptide, Leptin, and Insulin-Like Growth Factors in Breast Cancer Survivors. Cancer Epidemiology Biomarkers & Prevention 2005, 14: 2881-2888. PMID: 16365005, PMCID: PMC3000615, DOI: 10.1158/1055-9965.epi-05-0185.Peer-Reviewed Original ResearchConceptsInsulin-like growth factorBreast cancer survivorsBody mass indexPhysical activityC-peptideMass indexCancer survivorsInactive breast cancer patientsLow IGF-I levelsIGF-binding protein-3Growth factorHigher C-peptideIIIA breast cancerIGF-I levelsRelationship of obesityLower C-peptideBreast cancer patientsInterview-administered questionnairePhysical activity categoriesBreast cancer prognosisPopulation-based sampleHormones/peptidesLeptin levelsHigher IGFCancer patients
2003
Physical activity levels before and after a diagnosis of breast carcinoma
Irwin ML, Crumley D, McTiernan A, Bernstein L, Baumgartner R, Gilliland FD, Kriska A, Ballard‐Barbash R. Physical activity levels before and after a diagnosis of breast carcinoma. Cancer 2003, 97: 1746-1757. PMID: 12655532, PMCID: PMC3034406, DOI: 10.1002/cncr.11227.Peer-Reviewed Original ResearchMeSH KeywordsAdultBody WeightBreast NeoplasmsCarcinomaCohort StudiesFemaleHumansMiddle AgedMotor ActivityProspective StudiesConceptsBody mass indexPhysical activityBreast carcinomaIncident breast carcinomaPopulation-based studyRisk of recurrenceTotal physical activitySport physical activityPrediagnosis levelsAdjuvant treatmentPatient ageMass indexType of sportAdverse outcomesDisease stageTime patientsBaseline interviewBody weightPA levelsWeight gainPatientsDiagnosisCarcinomaWomenChemotherapy