2022
Adipose tissue radiodensity and mortality among patients with nonmetastatic breast cancer
Cheng E, Caan BJ, Chen WY, Irwin ML, Prado CM, Cespedes Feliciano EM. Adipose tissue radiodensity and mortality among patients with nonmetastatic breast cancer. Clinical Nutrition 2022, 41: 2607-2613. PMID: 36306565, PMCID: PMC9722634, DOI: 10.1016/j.clnu.2022.09.016.Peer-Reviewed Original ResearchConceptsNonmetastatic breast cancerVisceral adipose tissueBreast cancerBreast cancer prognosisOverall mortalitySpecific mortalityAdipose tissueCancer prognosisTissue radiodensityMultivariable Cox proportional hazards regressionKaiser Permanente Northern CaliforniaCox proportional hazards regressionRole of adiposityBody mass indexProportional hazards regressionBreast cancer survivalNovel prognostic markerThird lumbar vertebraIntegrated healthcare systemNon-Hispanic whitesMultiple cancer typesHazard ratioNonmetastatic patientsPrognostic factorsClinicopathological characteristics
2021
Prediagnosis and postdiagnosis leisure time physical activity and survival following diagnosis with ovarian cancer
Wang T, Townsend MK, Eliassen AH, Terry KL, Song M, Irwin ML, Tworoger SS. Prediagnosis and postdiagnosis leisure time physical activity and survival following diagnosis with ovarian cancer. International Journal Of Cancer 2021, 149: 1067-1075. PMID: 33963766, PMCID: PMC8282739, DOI: 10.1002/ijc.33676.Peer-Reviewed Original ResearchConceptsOvarian cancer-specific mortalityCancer-specific mortalityNurses' Health StudyPhysical activityHazard ratioOvarian cancerHealth StudyWeek 1MET-hours/weekLow-grade serous tumorsLeisure-time physical activityPostdiagnosis physical activityRisk of deathEpithelial ovarian cancerOvarian cancer survivalConfidence intervalsTime physical activityOvarian cancer diagnosisBetter prognosisSerous tumorsCancer survivalInverse associationLarge cohortDiagnosisCancer diagnosis
2020
Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial
Brown JC, Zhang S, Ligibel JA, Irwin ML, Jones LW, Campbell N, Pollak MN, Sorrentino A, Cartmel B, Harrigan M, Tolaney SM, Winer EP, Ng K, Abrams TA, Sanft T, Douglas PS, Hu FB, Fuchs CS, Meyerhardt JA. Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial. Cancer Prevention Research 2020, 13: 1055-1062. PMID: 32859615, PMCID: PMC7718298, DOI: 10.1158/1940-6207.capr-20-0188.Peer-Reviewed Original ResearchConceptsHs-CRPColorectal cancerPhysical activityHigh-sensitivity C-reactive proteinLow baseline physical activitySurvivors of breastTrial product estimandBaseline physical activityBiomarkers of inflammationC-reactive proteinMeasures of inflammationImproved clinical outcomesEffects of exerciseType 2 diabetesCombination of exerciseStandard therapyClinical outcomesCancer recurrenceObservational studyTreatment groupsInflammation outcomesMetforminIL6Factorial trialInflammation
2015
Weight Gain After Breast Cancer Diagnosis and All-Cause Mortality: Systematic Review and Meta-Analysis
Playdon MC, Bracken MB, Sanft TB, Ligibel JA, Harrigan M, Irwin ML. Weight Gain After Breast Cancer Diagnosis and All-Cause Mortality: Systematic Review and Meta-Analysis. Journal Of The National Cancer Institute 2015, 107: djv275. PMID: 26424778, PMCID: PMC4715249, DOI: 10.1093/jnci/djv275.Peer-Reviewed Original ResearchConceptsBody mass indexBreast cancer-specific mortalityCancer-specific mortalityCause mortalityWeight gainBreast cancer diagnosisBreast cancerStage I-IIIC breast cancerSystematic reviewPrediagnosis body mass indexWomen age 18 yearsPostdiagnosis weight gainCancer diagnosisCause mortality ratesBreast cancer mortalityAge 18 yearsWeb of ScienceCohort studyRecurrence outcomesMass indexCancer mortalityClinical trialsHigh riskMortality rateBody weight
2010
Fasting C-Peptide Levels and Death Resulting From All Causes and Breast Cancer: The Health, Eating, Activity, and Lifestyle Study
Irwin ML, Duggan C, Wang CY, Smith AW, McTiernan A, Baumgartner RN, Baumgartner KB, Bernstein L, Ballard-Barbash R. Fasting C-Peptide Levels and Death Resulting From All Causes and Breast Cancer: The Health, Eating, Activity, and Lifestyle Study. Journal Of Clinical Oncology 2010, 29: 47-53. PMID: 21115859, PMCID: PMC3055859, DOI: 10.1200/jco.2010.28.4752.Peer-Reviewed Original ResearchConceptsC-peptide levelsRisk of deathType 2 diabetesBreast cancerHazard ratioLifestyle StudyC-peptideDietary-induced weight lossSerum C-peptideCox regression analysisBody mass indexRegional breast cancerBreast cancer diagnosisMass indexInsulin secretionTreatment strategiesObservational studyEstrogen receptorPhysical activityCancerWeight lossCancer diagnosisCertain subgroupsWomenDeath
2008
Influence of Pre- and Postdiagnosis Physical Activity on Mortality in Breast Cancer Survivors: The Health, Eating, Activity, and Lifestyle Study
Irwin ML, Smith AW, McTiernan A, Ballard-Barbash R, Cronin K, Gilliland FD, Baumgartner RN, Baumgartner KB, Bernstein L. Influence of Pre- and Postdiagnosis Physical Activity on Mortality in Breast Cancer Survivors: The Health, Eating, Activity, and Lifestyle Study. Journal Of Clinical Oncology 2008, 26: 3958-3964. PMID: 18711185, PMCID: PMC2654316, DOI: 10.1200/jco.2007.15.9822.Peer-Reviewed Original ResearchConceptsPhysical activityBreast cancerHazard ratioLifestyle StudyTotal deathsModerate-intensity physical activityMultivariable hazard ratiosPostdiagnosis physical activityProspective observational studyBreast cancer deathsBreast cancer survivorsMetabolic equivalent hoursRegional breast cancerPostdiagnosis changesPrimary outcomeCancer survivorsPrimary exposureCancer deathInactive womenObservational studyLower riskGreater riskDiagnosisInfluence of preWomen
2005
Changes in Body Fat and Weight After a Breast Cancer Diagnosis: Influence of Demographic, Prognostic, and Lifestyle Factors
Irwin ML, McTiernan A, Baumgartner RN, Baumgartner KB, Bernstein L, Gilliland FD, Ballard-Barbash R. Changes in Body Fat and Weight After a Breast Cancer Diagnosis: Influence of Demographic, Prognostic, and Lifestyle Factors. Journal Of Clinical Oncology 2005, 23: 774-782. PMID: 15681521, PMCID: PMC3000612, DOI: 10.1200/jco.2005.04.036.Peer-Reviewed Original ResearchConceptsBody fat changesBody fatBreast cancer diagnosisLifestyle factorsPhysical activityFat changesCancer diagnosisHigher disease stagePopulation-based studyBreast cancer recurrenceBreast cancer prognosisPercent body fatFirst yearLean womenObese womenBaseline visitPotential cofoundersDisease stageLifestyle StudyPostdiagnosis periodCancer recurrenceBreast cancerCancer prognosisFat lossYounger age