2023
Randomized trial of exercise on cancer‐related blood biomarkers and survival in women with ovarian cancer
Cartmel B, Li F, Zhou Y, Gottlieb L, Lu L, Mszar R, Harrigan M, Ligibel J, Gogoi R, Schwartz P, Risch H, Irwin M. Randomized trial of exercise on cancer‐related blood biomarkers and survival in women with ovarian cancer. Cancer Medicine 2023, 12: 15492-15503. PMID: 37269192, PMCID: PMC10417064, DOI: 10.1002/cam4.6187.Peer-Reviewed Original ResearchConceptsExercise interventionOvarian cancerTrial of exerciseExercise-induced changesMin/weekGroup differencesSubset of participantsCause mortalityExercise groupOverall survivalStudy armsCA 125Randomized trialsBlood biomarkersBlood drawBreast cancerClinical significanceIGF-1Effect model analysisSecondary analysisBeneficial effectsCancerBiomarkersTrialsWomen
2020
Pilot study of combined aerobic and resistance exercise on fatigue for patients with head and neck cancer: Inflammatory and epigenetic changes
Xiao C, Beitler JJ, Higgins KA, Chico CE, Withycombe JS, Zhu Y, Zhao H, Lin IH, Li F, Jeon S, Irwin M, Bruner DW, Miller AH, Gary R. Pilot study of combined aerobic and resistance exercise on fatigue for patients with head and neck cancer: Inflammatory and epigenetic changes. Brain Behavior And Immunity 2020, 88: 184-192. PMID: 32330594, PMCID: PMC7415514, DOI: 10.1016/j.bbi.2020.04.044.Peer-Reviewed Original ResearchConceptsExercise groupInflammatory markersChair standNeck cancerBiceps curlSoluble TNF receptor IIMultidimensional Fatigue Inventory-20Tumor necrosis factor αPilot studyResistance exercise interventionTNF receptor IIPlasma interleukin-6Anti-inflammatory effectsC-reactive proteinPhysical function measuresIL1 receptor antagonistHand grip strengthNecrosis factor αIntensity-modulated radiotherapyStandard careExercise interventionWalk distanceRadiotherapy regimenHNC patientsMean age
2012
Post diagnosis weight gain and the role of exercise in breast cancer survivors.
Sanft T, Alvarez-Reeves M, Irwin M. Post diagnosis weight gain and the role of exercise in breast cancer survivors. Journal Of Clinical Oncology 2012, 30: 9007-9007. DOI: 10.1200/jco.2012.30.15_suppl.9007.Peer-Reviewed Original ResearchBone mineral densityLean body massDual-energy X-ray absorptiometryBreast cancer survivorsUsual careCA survivorsObese womenCancer survivorsBody fatBody compositionPoor breast cancer outcomesWeight gainFavorable body composition changesNon-obese womenBreast cancer outcomesRole of exerciseEffects of exerciseMin/wkPhysical activity levelsBody composition changesX-ray absorptiometrySupervised exerciseExercise groupExercise interventionUC group
2010
Adiposity changes after a 1-year aerobic exercise intervention among postmenopausal women: a randomized controlled trial
Friedenreich C, Woolcott C, McTiernan A, Terry T, Brant R, Ballard-Barbash R, Irwin M, Jones C, Boyd N, Yaffe M, Campbell K, McNeely M, Karvinen K, Courneya K. Adiposity changes after a 1-year aerobic exercise intervention among postmenopausal women: a randomized controlled trial. International Journal Of Obesity 2010, 35: 427-435. PMID: 20820172, PMCID: PMC3061001, DOI: 10.1038/ijo.2010.147.Peer-Reviewed Original ResearchConceptsAerobic exercise interventionTotal body fatExercise interventionPostmenopausal womenFat areaBody fatGreater body fat lossSubcutaneous abdominal fat areaCurrent public health guidelinesIntra-abdominal fat areaSedentary postmenopausal womenAbdominal fat areaAerobic exercise programExercise five timesBody fat lossDual-energy X-ray absorptiometry measurementsBreast cancer riskVolume of exerciseMeasures of adiposityPublic health guidelinesComputerized tomography measurementsExercise groupObese womenAbdominal adiposityExercise program
2009
Randomized Controlled Trial of Aerobic Exercise on Insulin and Insulin-like Growth Factors in Breast Cancer Survivors: The Yale Exercise and Survivorship Study
Irwin ML, Varma K, Alvarez-Reeves M, Cadmus L, Wiley A, Chung GG, DiPietro L, Mayne ST, Yu H. Randomized Controlled Trial of Aerobic Exercise on Insulin and Insulin-like Growth Factors in Breast Cancer Survivors: The Yale Exercise and Survivorship Study. Cancer Epidemiology Biomarkers & Prevention 2009, 18: 306-313. PMID: 19124513, PMCID: PMC2841479, DOI: 10.1158/1055-9965.epi-08-0531.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsPostmenopausal breast cancer survivorsModerate-intensity aerobic exerciseUsual care groupBreast cancer riskAerobic exerciseIGFBP-3Cancer survivorsUsual careCare groupCancer riskYale-New Haven Hospital Tumor RegistryCurrent physical activity levelsInsulin-like growth factorHospital tumor registryUsual care participantsAerobic exercise interventionExercise-induced decreasePhysical activity levelsInsulin-like growthExercise groupExercise interventionControlled TrialsTumor RegistryBrisk walking
2003
Effect of Exercise on Total and Intra-abdominal Body Fat in Postmenopausal Women: A Randomized Controlled Trial
Irwin ML, Yasui Y, Ulrich CM, Bowen D, Rudolph RE, Schwartz RS, Yukawa M, Aiello E, Potter JD, McTiernan A. Effect of Exercise on Total and Intra-abdominal Body Fat in Postmenopausal Women: A Randomized Controlled Trial. JAMA 2003, 289: 323-330. PMID: 12525233, DOI: 10.1001/jama.289.3.323.Peer-Reviewed Original ResearchConceptsSubcutaneous abdominal fatBody fat lossEffects of exercisePostmenopausal womenBody fatBody weightHome-based moderate-intensity exerciseAbdominal fatFat lossGreater body fat lossMajor public health concernSports/recreational activitiesObese postmenopausal womenIntra-abdominal fatPrevalence of obesityReduced body weightDuration of exerciseMin/wkModerate-intensity exerciseSignificant dose responseTotal body fatLevel of exerciseTwelve-month dataPublic health concernExercise group