2021
Impact of a randomized weight loss trial on breast tissue markers in breast cancer survivors.
Dieli-Conwright C, Harrigan M, Cartmel B, Chagpar A, Bai Y, Rimm D, Pusztai L, Lu L, Sanft T, Irwin M. Impact of a randomized weight loss trial on breast tissue markers in breast cancer survivors. Journal Of Clinical Oncology 2021, 39: e12501-e12501. DOI: 10.1200/jco.2021.39.15_suppl.e12501.Peer-Reviewed Original ResearchBreast cancer survivorsWeight loss interventionSerum insulin levelsCancer survivorsLoss interventionPercent body fatSerum levelsSerum biomarkersTissue biomarkersBody compositionMonth 6Insulin levelsBreast tissueBreast cancerInsulin receptorBody fatStage I breast cancerBreast tissue levelsI breast cancerWeight loss trialBreast tissue markersLevels of CD163Breast tissue biopsiesUsual careLifestyle interventionExamining the effect of obesity-associated gene variants on breast cancer survivors in a randomized weight loss intervention
Nguyen T, Irwin ML, Dewan AT, Cartmel B, Harrigan M, Ferrucci LM, Sanft T, Li F, Lu L, Salinas YD. Examining the effect of obesity-associated gene variants on breast cancer survivors in a randomized weight loss intervention. Breast Cancer Research And Treatment 2021, 187: 487-497. PMID: 33677781, DOI: 10.1007/s10549-021-06151-5.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsUsual care groupWeight loss interventionCancer survivorsLoss interventionCare groupFTO rs9939609Percent body fat changesWeight lossMeaningful weight lossBody fat changesBody mass indexObesity-associated gene FTOObesity-associated gene variantsPercent body fatGreater weight lossLifestyle interventionMass indexTreatment armsIntervention groupBreast cancerBody fatFat changesPurposeOur studyHealthy eating
2020
Skin carotenoids are inversely associated with adiposity in breast cancer survivors
Cartmel B, Anderson C, Irwin ML, Harrigan M, Sanft T, Li F, Gellermann W, Ermakov IV, Ferrucci LM. Skin carotenoids are inversely associated with adiposity in breast cancer survivors. Nutrition Research 2020, 79: 77-86. PMID: 32650223, PMCID: PMC7409553, DOI: 10.1016/j.nutres.2020.05.012.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsSkin carotenoid scoreUsual care groupCancer survivorsSkin carotenoidsBody fatCare groupSerum biomarkersAdiposity measuresLog C-reactive protein levelsBaseline percent body fatObese breast cancer survivorsC-reactive protein levelsDual-energy X-ray absorptiometryStrong associationBreast cancer patientsWeight loss trialStudy of overweightTotal body fatPercent body fatX-ray absorptiometryLog leptinPoor outcomeCancer patientsHip circumference
2012
Post diagnosis weight gain and the role of exercise in breast cancer survivors.
Sanft T, Alvarez-Reeves M, Irwin M. Post diagnosis weight gain and the role of exercise in breast cancer survivors. Journal Of Clinical Oncology 2012, 30: 9007-9007. DOI: 10.1200/jco.2012.30.15_suppl.9007.Peer-Reviewed Original ResearchBone mineral densityLean body massDual-energy X-ray absorptiometryBreast cancer survivorsUsual careCA survivorsObese womenCancer survivorsBody fatBody compositionPoor breast cancer outcomesWeight gainFavorable body composition changesNon-obese womenBreast cancer outcomesRole of exerciseEffects of exerciseMin/wkPhysical activity levelsBody composition changesX-ray absorptiometrySupervised exerciseExercise groupExercise interventionUC group
2010
Adiposity changes after a 1-year aerobic exercise intervention among postmenopausal women: a randomized controlled trial
Friedenreich C, Woolcott C, McTiernan A, Terry T, Brant R, Ballard-Barbash R, Irwin M, Jones C, Boyd N, Yaffe M, Campbell K, McNeely M, Karvinen K, Courneya K. Adiposity changes after a 1-year aerobic exercise intervention among postmenopausal women: a randomized controlled trial. International Journal Of Obesity 2010, 35: 427-435. PMID: 20820172, PMCID: PMC3061001, DOI: 10.1038/ijo.2010.147.Peer-Reviewed Original ResearchConceptsAerobic exercise interventionTotal body fatExercise interventionPostmenopausal womenFat areaBody fatGreater body fat lossSubcutaneous abdominal fat areaCurrent public health guidelinesIntra-abdominal fat areaSedentary postmenopausal womenAbdominal fat areaAerobic exercise programExercise five timesBody fat lossDual-energy X-ray absorptiometry measurementsBreast cancer riskVolume of exerciseMeasures of adiposityPublic health guidelinesComputerized tomography measurementsExercise groupObese womenAbdominal adiposityExercise program
2009
The Biological Mechanisms by Which Physical Activity Might Have an Impact on Outcome/Prognosis After a Breast Cancer Diagnosis
Irwin M. The Biological Mechanisms by Which Physical Activity Might Have an Impact on Outcome/Prognosis After a Breast Cancer Diagnosis. 2009, 97-111. DOI: 10.1007/978-1-4419-1173-5_6.Peer-Reviewed Original ResearchBreast cancer survivalBiological markersCancer survivalUrgent public health priorityTrial of exerciseBreast cancer deathsImpact of exercisePublic health priorityOutcome/prognosisBody fat levelsBreast cancer diagnosisEffects of PAPhysical inactivityCancer deathSmall RCTsSex hormonesBreast cancerHealth priorityPhysical activityBody fatHormonal concentrationsBeneficial effectsGrowth factorCancer diagnosisBeneficial changesExercise Improves Body Fat, Lean Mass, and Bone Mass in Breast Cancer Survivors
Irwin ML, Alvarez‐Reeves M, Cadmus L, Mierzejewski E, Mayne ST, Yu H, Chung GG, Jones B, Knobf MT, DiPietro L. Exercise Improves Body Fat, Lean Mass, and Bone Mass in Breast Cancer Survivors. Obesity 2009, 17: 1534-1541. PMID: 19629060, PMCID: PMC2841468, DOI: 10.1038/oby.2009.18.Peer-Reviewed Original ResearchConceptsModerate-intensity aerobic exerciseUsual care participantsBreast cancer survivorsMin/weekDual-energy X-ray absorptiometryUsual care groupBone mineral densityCancer survivorsAerobic exerciseCare participantsLean massBody fatBody compositionCare groupBone massYale-New Haven Hospital Tumor RegistryPostmenopausal breast cancer survivorsCurrent physical activity levelsHospital tumor registryAerobic exercise interventionPhysical activity levelsBreast cancer prognosisPercent body fatX-ray absorptiometryBreast cancer diagnosis
2005
Changes in Body Fat and Weight After a Breast Cancer Diagnosis: Influence of Demographic, Prognostic, and Lifestyle Factors
Irwin ML, McTiernan A, Baumgartner RN, Baumgartner KB, Bernstein L, Gilliland FD, Ballard-Barbash R. Changes in Body Fat and Weight After a Breast Cancer Diagnosis: Influence of Demographic, Prognostic, and Lifestyle Factors. Journal Of Clinical Oncology 2005, 23: 774-782. PMID: 15681521, PMCID: PMC3000612, DOI: 10.1200/jco.2005.04.036.Peer-Reviewed Original ResearchConceptsBody fat changesBody fatBreast cancer diagnosisLifestyle factorsPhysical activityFat changesCancer diagnosisHigher disease stagePopulation-based studyBreast cancer recurrenceBreast cancer prognosisPercent body fatFirst yearLean womenObese womenBaseline visitPotential cofoundersDisease stageLifestyle StudyPostdiagnosis periodCancer recurrenceBreast cancerCancer prognosisFat lossYounger age
2003
Effect of Exercise on Total and Intraabdominal Body Fat in Postmenopausal Women: A Randomized, Controlled Trial
Irwin M, Yasui Y, Ulrich C, Bowen D, Rudolph R, Schwartz R, Yukawa M, Aiello E, Potter J, McTiernan A. Effect of Exercise on Total and Intraabdominal Body Fat in Postmenopausal Women: A Randomized, Controlled Trial. Obstetrical & Gynecological Survey 2003, 58: 469-470. DOI: 10.1097/01.ogx.0000074098.18035.5e.Peer-Reviewed Original ResearchEffect of Exercise on Total and Intra-abdominal Body Fat in Postmenopausal Women: A Randomized Controlled Trial
Irwin ML, Yasui Y, Ulrich CM, Bowen D, Rudolph RE, Schwartz RS, Yukawa M, Aiello E, Potter JD, McTiernan A. Effect of Exercise on Total and Intra-abdominal Body Fat in Postmenopausal Women: A Randomized Controlled Trial. JAMA 2003, 289: 323-330. PMID: 12525233, DOI: 10.1001/jama.289.3.323.Peer-Reviewed Original ResearchConceptsSubcutaneous abdominal fatBody fat lossEffects of exercisePostmenopausal womenBody fatBody weightHome-based moderate-intensity exerciseAbdominal fatFat lossGreater body fat lossMajor public health concernSports/recreational activitiesObese postmenopausal womenIntra-abdominal fatPrevalence of obesityReduced body weightDuration of exerciseMin/wkModerate-intensity exerciseSignificant dose responseTotal body fatLevel of exerciseTwelve-month dataPublic health concernExercise group
2001
Estimation of Energy Expenditure from Physical Activity Measures: Determinants of Accuracy
Irwin M, Ainsworth B, Conway J. Estimation of Energy Expenditure from Physical Activity Measures: Determinants of Accuracy. Obesity 2001, 9: 517-525. PMID: 11557832, DOI: 10.1038/oby.2001.68.Peer-Reviewed Original ResearchConceptsBody fatPA recordsEnergy expenditureOverestimation of EESeven-Day Physical Activity RecallEstimation of EEMen 50 yearsBody mass indexHigher body fatnessPhysical activity levelsPhysical activity measuresPhysical activity recallYears of agePA assessment methodsEstimates of EEMass indexActivity recallBody fatnessBody weightOlder agePA levelsActivity measuresPA behaviorAdditional studiesPA measures