2024
Motor and sensory impairment in survivors of childhood central nervous system (CNS) tumors in the St. Jude Lifetime Cohort (SJLIFE)
Rodwin R, Wang F, Lu L, Li Z, Srivastava D, Phillips N, Khan R, Brinkman T, Krull K, Boop F, Armstrong G, Merchant T, Gajjar A, Robison L, Hudson M, Kadan‐Lottick N, Ness K. Motor and sensory impairment in survivors of childhood central nervous system (CNS) tumors in the St. Jude Lifetime Cohort (SJLIFE). Cancer Medicine 2024, 13: e7422. PMID: 39056576, PMCID: PMC11273544, DOI: 10.1002/cam4.7422.Peer-Reviewed Original ResearchConceptsSt. Jude Lifetime CohortQuality of lifeChildhood central nervous systemSurvivors of childhood CNS tumorsSensory impairmentChildhood CNS tumorsImpaired physical quality of lifeCentral nervous systemPhysical quality of lifeMotor impairmentCNS tumorsCommon Terminology Criteria for Adverse EventsModified total neuropathy scoreMultivariate modelIn-person evaluationAssociated with older ageClinical assessmentTotal Neuropathy ScoreNervous systemExposure to etoposideModified Common Terminology Criteria for Adverse EventsPrevalence of motorTreating motor impairmentIn-personCraniospinal irradiation
2021
Intratumour microbiome associated with the infiltration of cytotoxic CD8+ T cells and patient survival in cutaneous melanoma
Zhu G, Su H, Johnson CH, Khan SA, Kluger H, Lu L. Intratumour microbiome associated with the infiltration of cytotoxic CD8+ T cells and patient survival in cutaneous melanoma. European Journal Of Cancer 2021, 151: 25-34. PMID: 33962358, PMCID: PMC8184628, DOI: 10.1016/j.ejca.2021.03.053.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBacteriaBacterial LoadBacterial TranslocationChemokinesClostridialesCytotoxicity, ImmunologicFemaleGastrointestinal MicrobiomeHumansLymphocyte CountLymphocytes, Tumor-InfiltratingMaleMelanomaMiddle AgedPrognosisSkin NeoplasmsT-Lymphocytes, CytotoxicTumor MicroenvironmentYoung AdultConceptsT cellsCutaneous melanomaPatient survivalGut microbiomeAdjusted hazard ratioT cell infiltrationChemokine gene expressionChemokine levelsCytotoxic CD8Hazard ratioSystemic inflammationShorter survivalCCL5 expressionPatient outcomesCD8Immune responseMortality riskGut microbiotaSurvival analysisMelanomaTumor nicheHuman cancersSurvivalSignificant correlationPositive association
2019
The associations of work style and physical exercise with the risk of work-related musculoskeletal disorders in nurses
Yao Y, Zhao S, An Z, Wang S, Li H, Lu L, Yao S. The associations of work style and physical exercise with the risk of work-related musculoskeletal disorders in nurses. International Journal Of Occupational Medicine And Environmental Health 2019, 32: 15-24. PMID: 30793708, DOI: 10.13075/ijomeh.1896.01331.Peer-Reviewed Original ResearchConceptsWork-related musculoskeletal disordersPhysical exerciseMusculoskeletal disordersPrevalence of WMSDsNight shiftsRisk of WMSDsLack of exerciseSymptoms of WMSDsHospital nursing staffRisk factorsHigh prevalenceMunicipal HospitalNursing staffElevated riskLogistic regressionNursesPrevalenceCross-sectional survey designWork shiftDisordersExerciseRiskProfessional groupsAssociationPrevious year
2015
Joint Effect of Genotypic and Phenotypic Features of Reproductive Factors on Endometrial Cancer Risk
Wang Z, Risch H, Lu L, Irwin ML, Mayne S, Schwartz P, Rutherford T, De Vivo I, Yu H. Joint Effect of Genotypic and Phenotypic Features of Reproductive Factors on Endometrial Cancer Risk. Scientific Reports 2015, 5: 15582. PMID: 26498156, PMCID: PMC4620445, DOI: 10.1038/srep15582.Peer-Reviewed Original ResearchConceptsEndometrial cancer riskEndometrial cancerCancer riskEstrogen exposureEndometrial cancer patientsTime of studyGenetic risk scorePotential confoundersCancer patientsMenstrual cycleReproductive factorsRisk scorePossible markerMajor causeCancerMenopauseObesityPhenotypic featuresRiskPopulation controlsAgeMenarcheWomenExposureTNMC